📇 Rhumatologue · LE HAVRE · (76) · Libéral
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
2 raisons identifiées
Praticien-chercheur
9 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
119.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR IULIA CASAUX-VORONIUC
55 RUE DE SAINT QUENTIN, 76620 LE HAVRE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Bioactive materials · 2022
Romanian journal of ophthalmology · 2017
Frontiers in bioengineering and biotechnology · 2023
Introduction: Sjögren syndrome (SS) is an autoimmune disease characterized by salivary gland (SG) destruction leading to loss of secretory function. A hallmark of the disease is the presence of focal lymphocyte infiltration in SGs, which is predominantly composed of T cells. Currently, there are no effective therapies for SS. Recently, we demonstrated that a newly developed therapy using effective-mononuclear cells (E-MNCs) improved the function of radiation-injured SGs due to anti-inflammatory and regenerative effects. In this study, we investigated whether E-MNCs could ameliorate disease development in non-obese diabetic (NOD) mice as a model for primary SS.Methods: E-MNCs were obtained from peripheral blood mononuclear cells (PBMNCs) cultured for 7 days in serum-free medium supplemented with five specific recombinant proteins (5G culture). The anti-inflammatory characteristics of E-MNCs were then analyzed using a co-culture system with CD3/CD28-stimulated PBMNCs. To evaluate the therapeutic efficacy of E-MNCs against SS onset, E-MNCs were transplanted into SGs of NOD mice. Subsequently, saliva secretion, histological, and gene expression analyses of harvested SG were performed to investigate if E-MNCs therapy delays disease development.Results: First, we characterized that both human and mouse E-MNCs exhibited induction of CD11b/CD206-positive cells (M2 macrophages) and that human E-MNCs could inhibit inflammatory gene expressions in CD3/CD28- stimulated PBMNCs. Further analyses revealed that Msr1-and galectin3-positive macrophages (immunomodulatory M2c phenotype) were specifically induced in E-MNCs of both NOD and MHC class I-matched mice. Transplanted E-MNCs induced M2 macrophages and reduced the expression of T cell-derived chemokine-related and inflammatory genes in SG tissue of NOD mice at SS-onset. Then, E-MNCs suppressed the infiltration of CD4-positive T cells and facilitated the maintenance of saliva secretion for up to 12 weeks after E-MNC administration.Discussion: Thus, the immunomodulatory actions of E-MNCs could be part of a therapeutic strategy targeting the early stage of primary SS.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Kidney international · 2026 · Case Reports
Tom M, Iulia H, Sophie PM, Antoine D
Medical ultrasonography · 2025 · Journal Article
Roxana GI, Diana BA, Iulia C, Oana S, et al.
Bioactive materials · 2022 · Journal Article
Yuan B, Chen H, Zhao R, Deng X, et al.
Romanian journal of ophthalmology · 2017 · Journal Article
Iulia C, Ruxandra T, Costin LB, Liliana-Mary V
Life (Basel, Switzerland) · 2025 · Case Reports
Barboi OB, Vulpoi RA, Floria DE, Rosca V, et al.
Medicina (Kaunas, Lithuania) · 2025 · Journal Article
Rotar IC, Boitor Borza D, Staicu A, Goidescu IG, et al.
Current medical research and opinion · 2022 · Journal Article
Popa-Fotea NM, Scafa-Udriste A, Iulia G, Scarlatescu AI, et al.
Acta chirurgica Belgica · 2024 · Journal Article
Philippe H, Steven G, Iulia S, Geoffrey J, et al.
Frontiers in bioengineering and biotechnology · 2023 · Journal Article
Hasegawa K, Raudales JLM, I T, Yoshida T, et al.