M JEAN CABANE

Rhumatologue

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🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

Patient acceptable symptom state and minimal clinically important difference for patient-reported outcomes in systemic sclerosis: A secondary analysis of a randomized controlled trial comparing personalized physical therapy to usual care
2019
ArticleSeminars in Arthritis and Rheumatism

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (5)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Non à la diagonale des fous – L’œil de Réforme du 24 mars 2026 - reforme.net

📰 reforme.net · 24/03/2026

<a href="https://news.google.com/rss/articles/CBMinwFBVV95cUxOeHRBaVZ6WGVoUk42blU3RnJXOGtBeGs3eGlUS0F2bkNKS1pHRjFZY0Z1Zk94c3JJRE43c2JtQ3N0dm0zbnFVMTFDWWZNZllnN3R3aXpKQXZUYU5WRHRRaVpKU0xEMEdVSDVYeFJWenUteEVlTkhyTHdZU20yTTFaVGRTRjlCSGV2b2tGYXZ0WEt5NEpQUUVMY1JBQkxrOWc?oc=5" target="_blank">Non à la dia

L’œil de Réforme: supplément du samedi 10 janvier 2026 - reforme.net

📰 reforme.net · 10/01/2026

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxNcmllMmtqMlBNeWtOLWtiLUUwQktpbndUZVo2cWw2aG1reUthWW9oT1RDb0l6R3lkWjU5VE96T0wwMk1RRWpHbFI1VFNobHBrWnNWTU95NUYxNUFzOTY1R3lQbkFNZ1lrbG91emVGaWNiRm1uUmpJUG5TbjNxMFZhNmNTak9meUEydWpRZTd3d1d2UVhWaVE?oc=5" target="_blank">L’œil de Réforme: supplé

Pourquoi l’Office parlementaire qui enquête sur les effets secondaires des vaccins Covid ne rend-il pas publics tous ses débats ? - QG - Le média libre

📰 QG - Le média libre · 21/06/2022

<a href="https://news.google.com/rss/articles/CBMi_AFBVV95cUxONGhZbHgwQnZVdlZDV0FoVWdnNWJvUGgzMFI4TGFEMExkSmEzZWpLbk9OVE93S0dxaDR3bzA5MFNXSzZMZ3RaUTFibDNIM3l1NVR5S0dyTFIwaG1pQ2xWMkk3VE9oUDV2VGVGRGpHY25hZkQ0ZnMxWlpnRXdxZnFzVnhfSnhiSF9CUTR4X0pOYzVXbDlySkY1Ml94T1c4WUF6Yk8zVF8xTUp0TjF4RjVyRWxEenZad1ZjMj

Question de la semaine : qu'est-ce que le hoquet ? - Sciences et Avenir

📰 Sciences et Avenir · 08/02/2019

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxPVWVOV2NsVzdOMFBtbzN4anlaS2NVWHBVTHNTVTE1dTBJaTVjeDIwQXM3ZXRDakNPQ203MUtBVV9jOEc3SUp5c092anZ6X3I1dEdRV3hncUhpclhnYXRuOWdoUHY5TEVQbXdpcjdQY0d6MVhkTlhsd0lKdHJocXp1MFR0QW9FSmxOZ08yVkZwZWpmQQ?oc=5" target="_blank">Question de la semaine : qu'e

Paul Klee ou l'art de sublimer la douleur - Allo Docteurs

📰 Allo Docteurs · 29/06/2016

<a href="https://news.google.com/rss/articles/CBMisAFBVV95cUxPZ09WVFRrOU9rT29FekZwNGo3dFdwMzRodDdEMnk3UFc4elpsUTEwNUxCa0o5NjNxeTdrcFB5YXFsdklfWEl0dkVkaGRteE9MTFBvTl9IcllxVGxndHl2a2xQLTNVUmZfUHpMenpQbUgtTWFVNXpFYWpfZm1kZmdfT1BwcHd5SVEwQ3BEUnZtRUoyeWdtaVFVeFNBMGEtRk9UdTFUOXpoRkNPd2VVRmlmRQ?oc=5" targe

Top publications · les plus citées

The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France

Arthritis and rheumatism · 2009

📚 154 citations🎯 RCR 5.07Top 8% NIH

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AbstractObjectiveAn algorithm for the detection of pulmonary arterial hypertension (PAH), based on the presence of dyspnea and the findings of Doppler echocardiographic evaluation of the velocity of tricuspid regurgitation (VTR) and right‐sided heart catheterization (RHC), which was applied in a large multicenter systemic sclerosis (SSc) population, estimated the prevalence of PAH to be 7.85%. The aim of this observational study was to investigate the incidence of PAH and pulmonary hypertension (PH) during a 3‐year followup of patients from the same cohort (the ItinérAIR‐Sclérodermie Study).MethodsPatients with SSc and without evidence of PAH underwent evaluation for dyspnea and VTR at study entry and during subsequent visits. Patients in whom PAH was suspected because of a VTR of 2.8–3.0 meters/second and unexplained dyspnea or a VTR of >3.0 meters/second underwent RHC to confirm the diagnosis.ResultsA total of 384 patients were followed up for a mean ± SD of 41.03 ± 5.66 months (median 40.92 months). At baseline, 86.7% of the patients were women, and the mean ± SD age of the patients was 53.1 ± 12.0 years. The mean ± SD duration of SSc at study entry was 8.7 ± 7.6 years. After RHC, PAH was diagnosed in 8 patients, postcapillary PH in 8 patients, and PH associated with severe pulmonary fibrosis in 2 patients. The incidence of PAH was estimated to be 0.61 cases per 100 patient‐years. Two patients who exhibited a mean pulmonary artery pressure of 20–25 mm Hg at baseline subsequently developed PAH.ConclusionThe estimated incidence of PAH among patients with SSc was 0.61 cases per 100 patient‐years. The high incidence of postcapillary PH highlights the value of RHC in investigating suspected PAH.

Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis

Arthritis and rheumatism · 2009

📚 152 citations🎯 RCR 3.64Top 12% NIH

Lire l'abstract Crossref ↓

AbstractObjectiveThere is now growing evidence that connective tissue diseases, including systemic sclerosis (SSc), share a common genetic background. Microarray studies support a pivotal role of type I interferon (IFN) in the pathophysiology of connective tissue diseases. Interferon regulatory factors coordinate the expression of type I IFNs, and the IRF5 gene has been identified as a susceptibility gene of systemic lupus and Sjögren's syndrome. The aim of this study was to determine whether the IRF5 rs2004640 single‐nucleotide polymorphism is associated with SSc.MethodsThe IRF5 rs2004640 (GT) functional polymorphism was genotyped in 1,641 subjects of French European Caucasian origin: a discovery set comprising 427 patients with SSc and 380 control subjects and a replication set comprising 454 patients with SSc and 380 control subjects.ResultsIn both the discovery set and the replication set, the TT genotype was significantly more common in patients with SSc than in control subjects, with an odds ratio (OR) for the combined populations of 1.58 (95% confidence interval [95% CI] 1.18–2.11 [P for trend 0.002]). Analyses of the whole SSc population showed a significant association between homozygosity for the T allele and the presence of antinuclear antibodies (corrected P [Pcorr] = 0.04, OR 1.59, 95% CI 1.16–2.17) and fibrosing alveolitis (Pcorr = 0.001, OR 2.07, 95% CI 1.38–3.11). In a multivariate analysis model including the diffuse cutaneous subtype of SSc and positivity for anti–topoisomerase I antibodies, the IRF5 rs2004640 TT genotype remained associated with fibrosing alveolitis (P = 0.029, OR 1.92, 95% CI 1.07–3.44).ConclusionThe IRF5 rs2004640 GT substitution is associated with susceptibility to SSc. These data provide new insight into the pathogenesis of SSc, including clues to the mechanisms leading to fibrosing alveolitis.

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

The Journal of rheumatology · 2010

📚 133 citations🎯 RCR 4.79Top 8% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Objective.To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).Methods.This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.Results.We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.Conclusion.Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.

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Articles de presse (5)

Top publications · les plus citées

Publications scientifiques (31) — classées par pathologie

Sclérodermie9

Transversal7

Corticothérapie4

Épidémiologie & registres4

Essai clinique3

Activité physique / Rééducation2

Génétique2

Vascularites2

Qualité de vie / PROMs1

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