📇 Rhumatologue · BOURGOIN JALLIEU CEDEX · (38) · Salarié
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3 raisons identifiées
Encadrant universitaire
Forme la prochaine génération de rhumatologues (2 thèses dirigées)
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
120.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Visualisation des circuits neuronaux chez les vertébrés : développement de nouveaux marqueurs génétiques
2001Doctorant·e : Karima Kissa
Role du gene homeotique hoxc-8 dans l'identite des motoneurones brachiaux chez la souris
1997Doctorant·e : Laurent Tiret
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
42
42 articles ont été cités au moins 42fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
6 733
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
71
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
59
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Centre National de la Recherche Scientifique · Laboratoire de Neurobiologie Cellulaire et Moléculaire
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Adenoma detection with blue-water infusion colonoscopy: a randomized trial
2017ArticleEndoscopy
Bioluminescent properties of obelin and aequorin with novel coelenterazine analogues.
2014ArticleAnalytical and Bioanalytical Chemistry
Electron-multiplying charge-coupled detector-based bioluminescence recording of single-cell Ca2+.
2008ArticleJournal of Biomedical Optics
Bioluminescent imaging of Ca2+ activity reveals spatiotemporal dynamics in glial networks of dark-adapted mouse retina.
2007ArticleThe Journal of Physiology
Non-invasive in vivo imaging of calcium signaling in mice.
2007ArticlePLoS ONE
In vivo Bioluminescence Imaging of Ca Signalling in the Brain of Drosophila.
2007ArticlePLoS ONE
Red-shifted aequorin-based bioluminescent reporters for in vivo imaging of Ca2 signaling.
2007ArticleMolecular Imaging
Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals.
2006ArticleEuropean Journal of Neuroscience
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CH PIERRE OUDOT BOURGOIN JALLIEU
30 AV DU MEDIPOLE BP 40348, 38302 BOURGOIN JALLIEU CEDEX
GASTRO NORD ISERE
SELARL GASTRO NORD ISERE 37 AVENUE DU MEDIPOLE, 38300 BOURGOIN JALLIEU
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Proceedings of the National Academy of Sciences of the United States of America · 2002
The function of the nervous system is a consequence of the intricate synaptic connectivity of its neurons. Our understanding of these highly complex networks has profited enormously from methods used over the past two decades that are based on the mechanical injection of tracer molecules into brain regions. We have developed a genetic system for the mapping of synaptic connections during development of the mammalian central nervous system and in the mature brain. It is based on the transsynaptic transfer of green fluorescent protein (GFP) in the brains of mice using a fusion protein with a nontoxic fragment of tetanus toxin (TTC) expressed in defined neurons. These transgenic mice allowed us to visualize neurons, at single-cell resolution, that are in synaptic contact by the detection of GFP in interconnected circuits. Targeted genetic expression with a specific promoter permitted us to transfer GFP to defined subsets of neurons and brain regions. GFP–TTC is coexpressed with a lacZ reporter gene to discriminate neurons that produce the tracer from cells that have acquired it transneuronally. The marker shows selective transfer in the retrograde direction. We have used electron microscopic detection of GFP to define the ultrastructural features of the system. Our work opens up a range of possibilities for brain slice and in vivo studies taking advantage of the fluorescence of GFP. We point the way toward the use of powerful multiphoton technology and set the stage for the transsynaptic transfer of other proteins in the brains of mice.
Endoscopy · 2017
Abstract Background and aims Colonoscopy is currently the reference method to detect colorectal neoplasia, yet some adenomas remain undetected. The water infusion technique and dying with indigo carmine has shown interesting results for reducing this miss rate. The aim of this study was to compare the adenoma detection rate (adenoma and adenocarcinoma; ADR) and the mean number of adenomas per patient (MAP) for blue-water infusion colonoscopy (BWIC) versus standard colonoscopy. Methods We performed a multicenter, randomized controlled trial in eight units, including patients with a validated indication for colonoscopy (symptoms, familial or personal history, fecal occult blood test positive). Consenting patients were randomized 1:1 to BWIC or standard colonoscopy. All colonoscopies were performed by experienced colonoscopists. All colonoscopy quality indicators were prospectively recorded. Results Among the 1065 patients included, colonoscopies were performed completely for 983 patients (514 men; mean age 59.1). The ADR was not significantly different between the groups; 40.4 % in the BWIC group versus 37.5 % in the standard colonoscopy group (odds ratio [OR] 1.13; 95 % confidence interval [CI] 0.87 – 1.48; P = 0.35). MAP was significantly greater in the BWIC group (0.79) than in the standard colonoscopy group (0.64; P = 0.005). For advanced adenomas, the results were 50 (10.2 %) and 36 (7.3 %), respectively (P = 0.10). The cecal intubation rate was not different but the time to cecal intubation was significantly longer in BWIC group (9.9 versus 6.2 minutes; P < 0.001). Conclusion Despite the higher MAP with BWIC, the routine use of BWIC does not translate to a higher ADR. Whether increased detection ultimately results in a lower rate of interval carcinoma is not yet known.Clinical trials registration: EudraCT 2012-A00548 – 35; NCT01937429.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Endoscopy · 2017 · Comparative Study
Lesne A, Rouquette O, Touzet S, Petit-Laurent F, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2002 · Journal Article
Maskos U, Kissa K, St Cloment C, Brûlet P