📇 Rhumatologue · ARMENTIERES CEDEX · (59) · Salarié

M DIDIER BRIEMANT

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Auteur de référence en rhumatologie
23 articles scientifiques publiés — un praticien à la pointe de la recherche
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📍 ARMENTIERES CEDEX (59)SalariéRPPS 10002255478

✨ Génération du profil synthétique IA en cours…

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CH ARMENTIERES
112 R SADI CARNOT BP 189, 59421 ARMENTIERES CEDEX
☎ 0320483333Activité de soin et de pharmacie🏥 Centre CH ↗
SDIS DU PAS DE CALAIS
SDIS DU PAS DE CALAIS 18 RUE RENE CASSIN BP 77, 62052 ST LAURENT BLANGY CEDEX
☎ 0321218000

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Top publications · les plus citées

Anticoagulation and Antiplatelet Therapy Versus Anticoagulation Alone in Patients With Chronic Coronary Syndrome Receiving Long-Term Anticoagulation: A Meta-Analysis of Randomized Clinical Trials

Circulation · 2026

📚 6 citations🎯 RCR 6.00

Left ventricular global longitudinal strain impairment during long-term hydroxychloroquine exposure

International journal of cardiology · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study)

Journal of internal medicine · 2026

📚 1 citations🔓 Open Access

Lire l'abstract Crossref ↓

Abstract Objectives To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP‐ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD. Methods A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP‐ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months. Results In our study, 39% of patients had RP‐ILD at ILD diagnosis. Multivariate logistic regression analysis with cluster‐robust SE identified the factors associated with RP‐ILD at ILD diagnosis as male sex (aOR = 9.7 [1.6–59.5], p = 0.006), fever (aOR = 128 [12.6–1300], p < 0.001), organizing pneumonia (OP) pattern (aOR = 66.8 [3.4–1316], p = 0.006), and pleural effusion (aOR = 20.2 [1.1–373], p = 0.04), whereas RP‐ILD was associated with lower likelihood of severe muscle disease (aOR = 0.004 [0.0001–0.13], p = 0.002). Clustering analysis identified four distinct groups: Cluster 1 ( n = 62) included patients with systemic presentation, non‐RP‐ILD at ILD diagnosis, and anti‐Jo‐1 antibodies with good prognosis; Cluster 2 ( n = 40) included older age patients with more RP‐ILD at ILD diagnosis, pleuropericarditis, and a higher mortality rate. Conclusion Fever, pleural effusion, and OP pattern were independently associated with RP‐ILD in ASyS patients. Unsupervised cluster analysis identified a severe inflammatory phenotype in ASyS patients with ILD.

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M DIDIER BRIEMANT

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Top publications · les plus citées

Publications scientifiques (23) — classées par pathologie

Transversal11

Case report / série3

csDMARDs2

Épidémiologie & registres2

Essai clinique2

Revue générale2

Biomarqueurs / Auto-Ac1

Revue / méta-analyse1

Vascularites des gros vaisseaux1

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