M MICHEL BRETTIER

Rhumatologue

RPPS 10002117058

✨ Profil synthétique

IA · 19/05/2026

Le Dr Michel Brettier est un rhumatologue qui a publié des travaux sur diverses pathologies et sujets liés à la rhumatologie. Ses publications sur PubMed couvrent des domaines tels que l'épidémiologie, les essais cliniques et la gériatrie. Il a également rédigé des revues générales et des méta-analyses sur des sujets spécifiques.

Expertises présumées

Rhumatologie gériatrique
Épidémiologie des maladies rhumatismales
Essais cliniques en rhumatologie
Revue systématique de la littérature médicale
Méta-analyse en rhumatologie
Gériatrie et maladies rhumatismales

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

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Top publications · les plus citées

Tracking organic mercury bioaccumulation by the brown mussel Perna perna (Linnaeus, 1758) in subtropical bays: Environmental exposure and seasonal effects

Marine pollution bulletin · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

Outcomes and Safety of Revascularization Approaches for Stroke Related to Isolated Vertebral Artery Occlusions (BRAVO)

Stroke · 2026

📚 1 citations🔓 Open Access

Lire l'abstract Crossref ↓

BACKGROUND: The best revascularization strategy for acute ischemic stroke from isolated vertebral artery occlusion remains unclear. METHODS: This retrospective, international, multicenter cohort study included patients from 30 comprehensive stroke centers across Europe (n=23), North America (n=5), and Asia (n=2) between 2016 and 2022. Eligible patients presented with acute ischemic stroke within 24 hours of last seen well and had imaging-confirmed isolated vertebral artery occlusion. Two treatment comparisons were analyzed: intravenous thrombolysis (IVT)-only versus conservative treatment (Cx), and endovascular treatment (EVT)±IVT versus medical management (Cx and IVT). The primary outcome was the shift in 3-month modified Rankin Scale (mRS) score; secondary outcomes included early neurological improvement (24-hour-delta National Institutes of Health Stroke Scale score), recanalization, early neurological deterioration of ischemic origin, symptomatic intracerebral hemorrhage, and 3-month mortality. Analyses were adjusted using inverse probability of treatment weighting (IPTW). RESULTS: Among 494 patients, 143 (29%) received Cx, 218 (44%) IVT-only, and 133 (27%) EVT±IVT. Compared with Cx, IVT-only showed similar 3-month mRS score (IPTW-adjusted odds ratio [aOR] mRS shift score, 1.32 [95% CI, 0.80–2.18]), greater early neurological improvement (IPTW-adjusted-β coefficient, −1 [95% CI, −2.05 to 0.05]), and higher recanalization rates (IPTW-aOR, 4.33 [95% CI, 1.36–13.78]). Compared with MM (=IVT+Cx), EVT±IVT was associated with an unfavorable mRS shift score (IPTW-aOR mRS shift score, 0.51 [95% CI, 0.35–0.74]), higher early neurological deterioration of ischemic origin (IPTW-aOR, 9.06 [95% CI, 2.86–28.67]), and symptomatic intracerebral hemorrhage (IPTW-aOR, 6.05 [95% CI, 1.14–32.1]) though recanalization was over 4-fold higher (OR, 4.64 [95% CI, 1.90–11.33]). Patients with National Institutes of Health Stroke Scale score ≥10 showed point estimates favoring EVT+IVT ( P interaction =0.025). CONCLUSIONS: IVT-only appeared safe and was associated with better early recovery and recanalization. EVT±IVT showed overall worse outcomes, potentially due to increased early neurological deterioration of ischemic origin and symptomatic intracerebral hemorrhage rates, but may confer benefit in moderate-to-severe strokes, warranting prospective trials in symptomatic isolated vertebral artery occlusion.

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M MICHEL BRETTIER

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal33

Revue générale5

Épidémiologie & registres4

Revue / méta-analyse3

Essai clinique2

Case report / série1

Gériatrie1

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

Vraie vie / RWE1

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