📇 Rhumatologue · MONTDIDIER · (80) · Libéral
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2 raisons identifiées
Auteur de référence en rhumatologie
33 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
126 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR SOPHIE BOUTEILLIER-BAUWENS
17 RUE GEORGES AMSON, 80500 MONTDIDIER
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Frontiers in immunology · 2025
Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation and progressive joint destruction. Genetic and environmental risk factors contribute to the development of rheumatoid arthritis (RA). Among environmental factors, seasonal cycles are reported to impact the clinical phenotypes in RA, with rheumatic flares being aggravated during the winter season. Gaining insight into the seasonal effects on molecular drivers can be vital in resolving seasonal cycles in RA pathogenesis. To understand this phenomenon, genome-wide association study (GWAS) and candidate genes were reviewed to identify their role in susceptibility to RA. Subsequently, it was verified how many of these genes are modulated by seasonal influences. Furthermore, the role of epigenetic modifications, such as DNA methylation and non-coding RNAs, involved in RA pathogenesis and whether these epigenetic effects are also impacted by seasonal fluctuation were examined. Finally, it was investigated how these genetic and epigenetic mechanisms result in the breakdown of self-tolerance and the initiation of an autoimmune action. Upon overlapping the genetic and epigenetic observations influenced by seasonal cycles, it was evident that seasonal cycles do impact the genetic and epigenetic machinery, which possibly can explain the reasons for seasonal flares in RA pathogenesis. The evidence indicates that genetic and epigenetic mechanisms are driven by climatic variation and that the timing and duration of the aberrant expression of immune response genes will drive the autoantibodies to develop seasonal flares of RA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Kidney international · 2026 · Case Reports
Tom M, Iulia H, Sophie PM, Antoine D
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Céline M, Jennifer VS, Xavier O, Baptiste F, et al.
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Akhil A, Joseph JR, Puttegowda VD, V M, et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025 · Journal Article
Marlies F, Florian H, Julia T, Sandra D, et al.
Biomedical physics & engineering express · 2025 · Journal Article
D K, D P, P V, G A, et al.
Alzheimer disease and associated disorders · 2025 · Journal Article
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Chintham S, S M, Periasamy P, Gopalakrishnan S
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2025 · Case Reports
Khalique A, Bashir H, Bin Yousuf S, Ullah S, et al.
PloS one · 2025 · Journal Article
S DSN, Sundararajan V
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Annapareddy A, Bose VC, Katariya AA, Mulpur P, et al.
Health economics review · 2025 · Journal Article
Shobha V, Singhai S, Haridas V, V S, et al.
Journal of central nervous system disease · 2025 · Case Reports
Panagiotis CI, Hakim A, Lidia S, Christine SN, et al.
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Sophie H, Emmanuel J, David H, Philippe U, et al.
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Agrawal AC, Sarkar S, Sakale H, Rojasara J, et al.
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Magalie VV, Rosina D, Lucienne M, Wim D, et al.
Journal of central nervous system disease · 2025 · Case Reports
Panagiotis CI, Hakim A, Lidia S, Christine SN, et al.
Cureus · 2025 · Case Reports
Ghosh S, Vittobarao PG, S S, L A, et al.
Cureus · 2024 · Case Reports
Agrawal AC, Sarkar S, Sakale H, Rojasara J, et al.
Mediterranean journal of rheumatology · 2025 · Journal Article
S C, Shenoy P, Kumar U, Pandya S, et al.
Vaccine · 2024 · Journal Article
Magali P, Sophie M, Arnaud B, Pol L, et al.
Cureus · 2025 · Journal Article
S Y, Radhakrishnan P, Krishnamurthy D, Cherukkumalli N, et al.
Cureus · 2023 · Journal Article
S S, R S
Seminars in arthritis and rheumatism · 2025 · Published Erratum
Achten H, Liselotte D, Sophie V, Kristel B, et al.
Seminars in arthritis and rheumatism · 2025 · Journal Article
Achten H, Liselotte D, Sophie V, Kristel B, et al.
Cureus · 2024 · Case Reports
Jayakumar A, S H, Philip T, Jomey MR
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Frontiers in immunology · 2025 · Journal Article
E K KP, P R S, S S, Banerjee M
Cureus · 2024 · Case Reports
Sharma PK, S S, Christina EP, Gunasekaran D
Frontiers in immunology · 2026 · Journal Article
Khatri R, Jose A, Rajadhyaksha A, Mehta K, et al.
Pediatric blood & cancer · 2026 · Journal Article
Sandrine V, Sophie B, Cécile R, Cyrielle C, et al.
Annals of rehabilitation medicine · 2025 · Journal Article
Agarwal V, S J, Sharma A
MethodsX · 2024 · Journal Article
Shetty S, Gudi N, S EAR, Maiya GA, et al.
Annals of rehabilitation medicine · 2024 · Journal Article
Agarwal V, S J, Sharma A
MethodsX · 2024 · Journal Article
Shetty S, Gudi N, S EAR, Maiya GA, et al.
Cureus · 2024 · Journal Article
S D, R K
Cureus · 2024 · Case Reports
S V, Murugesan H, Ramanathan K, Selvaraj C