M CHRISTIAN BOUCHER

Rhumatologue

RPPS 10001989853

📊 Reconnaissance scientifique : 38/100📝 87 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Profil synthétique

IA · 19/05/2026

Le Dr Christian Boucher est un rhumatologue avec une production scientifique notable, comme en témoignent ses 87 publications et son h-index de 38. Ses recherches portent principalement sur les interactions entre les plantes et les micro-organismes, ainsi que sur la génétique. Cette expertise dans la recherche fondamentale pourrait avoir des applications dans la compréhension des maladies rhumatismales.

Expertises présumées

Génétique des maladies rhumatismales
Immunologie des maladies auto-immunes
Rhume polyarthrite
Spondylarthrite
Lupus érythémateux disséminé
Maladies auto-immunes systémiques
Génétique moléculaire

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

38 articles ont été cités au moins 38fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Inventory and functional analysis of the large Hrp regulon in Ralstonia solanacearum: identification of novel effector proteins translocated to plant host cells through the type III secretion system

Molecular microbiology · 2004

📚 182 citations🎯 RCR 3.96Top 11% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

SummaryThe ability of Ralstonia solanacearum strain GMI1000 to cause disease on a wide range of host plants (including most Solanaceae and Arabidopsis thaliana) depends on genes activated by the regulatory gene hrpB. HrpB controls the expression of the type III secretion system (TTSS) and pathogenicity effectors transiting through this pathway. In order to establish the complete repertoire of TTSS‐dependent effectors belonging to the Hrp regulon and to start their functional analysis, we developed a rapid method for insertional mutagenesis, which was used to monitor the expression of 71 candidate genes and disrupt 56 of them. This analysis yielded a total of 48 novel hrpB‐regulated genes. Using the Bordetella pertussis calmodulin‐dependent adenylate cyclase reporter fusion system, we provide direct biochemical evidence that five R. solanacearum effector proteins are translocated into plant host cells through the TTSS. Among these novel TTSS effectors, RipA and RipG both belong to multigenic families, RipG defining a novel class of leucine‐rich‐repeats harbouring proteins. The members of these multigenic families are differentially regulated, being composed of genes expressed in either an hrpB‐dependent or an hrpB‐independent manner. Pathogenicity assays of the 56 mutant strains on two host plants indicate that, with two exceptions, mutations in individual effectors have no effect on virulence, a probable consequence of genetic and functional redundancy. This large repertoire of HrpB‐regulated genes, which comprises > 20 probable TTSS effector genes with no counterparts in other bacterial species, represents an important step towards a full‐genome understanding of R. solanacearum virulence.

Ralstonia solanacearum requires F-box-like domain-containing type III effectors to promote disease on several host plants

Proceedings of the National Academy of Sciences of the United States of America · 2006

📚 161 citations🎯 RCR 3.47Top 13% NIH

Lire l'abstract Crossref ↓

The phytopathogenic bacterium Ralstonia solanacearum encodes a family of seven type III secretion system (T3SS) effectors that contain both a leucine-rich repeat and an F-box domain. This structure is reminiscent of a class of typical eukaryotic proteins called F-box proteins. The latter, together with Skp1 and Cullin1 subunits, constitute the SCF-type E3 ubiquitin ligase complex and control specific protein ubiquitinylation. In the eukaryotic cell, depending on the nature of the polyubiquitin chain, the ubiquitin-tagged proteins either see their properties modified or are doomed for degradation by the 26S proteasome. This pathway is essential to many developmental processes in plants, ranging from hormone signaling and flower development to stress responses. Here, we show that these previously undescribed T3SS effectors are putative bacterial F-box proteins capable of interacting with a subset of the 19 different Arabidopsis Skp1-like proteins like bona fide Arabidopsis F-box proteins. A R. solanacearum strain in which all of the seven GALA effector genes have been deleted or mutated was no longer pathogenic on Arabidopsis and less virulent on tomato. Furthermore, we found that GALA7 is a host-specificity factor, required for disease on Medicago truncatula plants. Our results indicate that the GALA T3SS effectors are essential to R. solanacearum to control disease. Because the F-box domain is essential to the virulence function of GALA7, we hypothesize that these effectors act by hijacking their host SCF-type E3 ubiquitin ligases to interfere with their host ubiquitin/proteasome pathway to promote disease.

Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum

PLoS pathogens · 2006

📚 149 citations🎯 RCR 3.63Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

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M CHRISTIAN BOUCHER

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Articles de presse (2)

Top publications · les plus citées

Publications scientifiques (20) — classées par pathologie

Transversal16

Génétique4

Revue générale1

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