📇 Rhumatologue · COLOMBES CEDEX · (92) · Hospitalier
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3 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
136 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
GHU APHP NUP SITE LOUIS MOURIER
178 R DES RENOUILLIERS, 92701 COLOMBES CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Arthritis and rheumatism · 2004
AbstractObjectiveA disease resembling the human spondylarthropathies develops in HLA–B27–transgenic rats. This disease in rats is mediated by CD4+ T cells, but antigen‐presenting cells (APCs) may also play a role. Dendritic cells (DCs) have been reported to be defective in allogeneic mixed lymphocyte culture in this model. Here, we further investigated the functional defect of APCs.MethodsDCs and B cells from nontransgenic, HLA–B27 (33–3)–transgenic, and HLA–B7 (120–4)–transgenic rats were used to stimulate T cells. Surface expression of HLA–B transgene and rat molecules on APCs and the formation of conjugates between DCs and T cells were monitored by flow cytometry.ResultsWe observed a strikingly defective stimulation of allogeneic and syngeneic T lymphocytes by APCs from HLA–B27 but not HLA–B7 rats, even if stimulation was driven in the presence of anti–T cell receptor (TCR) antibody. We found no evidence that HLA–B27 DCs were immature, lacked production of some diffusible factor, or produced an inhibitory factor for T cells. When comparing the levels of expression of class II major histocompatibility complex, CD2, intercellular adhesion molecule 1, lymphocyte function–associated antigen 1, B7, and CD40 molecules at the surface of DCs from 33‐3, 120‐4, and nontransgenic rats, we found little difference. However, HLA–B27–transgenic DCs formed fewer conjugates with T cells than did nontransgenic DCs. Furthermore, the proportion of conjugates formed between DCs and T cells, as well as the difference between nontransgenic and HLA–B27–transgenic DCs, were in large part reduced by blocking CD86 on DCs.ConclusionWe confirmed defective stimulation of T cells by APCs in HLA–B27 rats, the mechanism of which appears to implicate APC/T cell contact, independent of TCR engagement. In addition, decreased use of the CD86 costimulatory molecule by B27 DCs was observed. Impaired costimulatory function could result in a loss of tolerance toward microbial flora in this model.
Clinical interventions in aging · 2017
Journal of aging and health · 2009
Objective: There may be ethical issues associated with allowing certain inpatients to vote as some may be cognitively impaired. During the 2007 elections in France, we conducted a prospective observational study on voting among hospitalized patients. Method: Patients hospitalized in an Internal Medicine and Geriatric Department on election day were included. The primary outcome was the turnout among registered inpatients, and secondary outcomes were Mini-Mental State Examination (MMSE) scores and reasons for abstention. Results: Of 142 inpatients (mean age 73 years), 84 were eligible to vote, and 22 actually voted (turnout 25.2%). Among the voters, 23% had an MMSE score of less than 12; 58% of abstentions were procedure-related. Discussion: In our study, some inpatients did not vote as a result of procedural issues. When patients with severe cognitive impairment vote, there is a potential risk of vote diversion. Voting procedures should be improved to give inpatients easier access to the ballot while protecting them from the risk of fraud.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
IDCases · 2025 · Case Reports
Affo C, Tisseau des Escotais J, Bosquet A, Mahé I
EJHaem · 2024 · Journal Article
Affo C, Schmidt C, Bosquet A, Dumont B, et al.
BMJ open · 2018 · Journal Article
Bosquet A, Mahé I
Clinical interventions in aging · 2017 · Journal Article
Gilbert T, Bosquet A, Thomas-Antérion C, Bonnefoy M, et al.
Journal of aging & social policy · 2015 · Journal Article
Bosquet A, El Massioui F, Mahé I
Psychologie & neuropsychiatrie du vieillissement · 2010 · English Abstract
Bosquet A, Medjkane A, Vinceneux P, Mahé I
Journal of aging and health · 2009 · Journal Article
Bosquet A, Medjkane A, Voitel-Warneke D, Vinceneux P, et al.
Presse medicale (Paris, France : 1983) · 2007 · English Abstract
Mahé I, Bosquet A, Bartolucci P, Rist S, et al.
La Revue de medecine interne · 2005 · Case Reports
Rist S, Manceron V, Bartolucci P, Grasland A, et al.
PloS one · 2022 · Journal Article
Bosquet A, Affo C, Plaisance L, Poenou G, et al.
Arthritis and rheumatism · 2004 · Journal Article
Hacquard-Bouder C, Falgarone G, Bosquet A, Smaoui F, et al.
BMC infectious diseases · 2025 · Journal Article
Bosquet A, Affo C, Happe F, Helfer H, et al.
BMC infectious diseases · 2025 · Journal Article
Bosquet A, Affo C, Happe F, Helfer H, et al.
Archives francaises de pediatrie · 1960 · Journal Article
LELONG M, CANLORBE P, BERKMAN M, VASSAL J, et al.
Additional file 8 of COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Supplementary Material 8
COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Abstract In early 2020, no drug had proven efficacy to treat COVID-19 in-patients. This work aimed to describe COVID-19 treatment for in-patients worldwide until June, 2020. A PubMed search was performed with the terms “
Additional file 4 of COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Supplementary Material 4
COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Abstract In early 2020, no drug had proven efficacy to treat COVID-19 in-patients. This work aimed to describe COVID-19 treatment for in-patients worldwide until June, 2020. A PubMed search was performed with the terms “
Additional file 4 of COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Supplementary Material 4
Additional file 8 of COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review
Supplementary Material 8
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).