📇 Rhumatologue · CREPY EN VALOIS · (60) · Libéral

MME IRENE BORONCZYK-SZPYTMA

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
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73.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CREPY EN VALOIS (60)LibéralRPPS 10001792315

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR IRENE BORONCZYK-SZPYTMA
23 RUE JEANNE D ARC, 60800 CREPY EN VALOIS
☎ 0344591139Activité de soin et de pharmacie

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Top publications · les plus citées

Gut microbiota alterations in critically ill older patients: a multicenter study

BMC geriatrics · 2022

📚 28 citations🎯 RCR 2.68Top 19% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p < 0.05); beta diversity evidenced significant differences between the groups (PERMANOVA = 1.19, p = 0.038). The microbiota of the adults under 60 years old showed greater abundance of Murdochiella, Megasphaera, Peptoniphilus and Ezakiella, whereas those over 60 years old Escherichia-Shigella and Hungatella were more abundant. Conclusion The gut microbial community was altered by different factors; however, age significantly explained the variability in critically ill patients. A lower presence of beneficial genera and a higher abundance of pathogens was observed in adults over 60 years old.

Cyclophosphamide treatment in active multiple sclerosis

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021

📚 20 citations🎯 RCR 1.68

Lewy body dementia promotion by air pollutants

Science (New York, N.Y.) · 2025

📚 17 citations🎯 RCR 6.77🔓 Open Access

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Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM 2.5 ) exposure raises LBD risk. Mechanistically, we found that PM 2.5 exposure led to brain atrophy in wild-type mice, an effect not seen in α-synuclein (αSyn)–deficient mice. PM 2.5 exposure generated a highly pathogenic αSyn strain, PM 2.5 –induced preformed fibril (PM-PFF), with enhanced proteinase K resistance and neurotoxicity, resembling αSyn LBD strains. PM 2.5 samples from China, the United States, and Europe consistently induced proteinase-resistant αSyn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM 2.5 -exposed mice and LBD patients, underscoring PM 2.5 ’s role in LBD and stressing the need for interventions to reduce air pollution and its associated neurological disease burden.

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MME IRENE BORONCZYK-SZPYTMA

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal30

Pédiatrie6

Revue générale6

Qualité de vie / PROMs3

Revue / méta-analyse2

Case report / série1

Économie santé1

Gériatrie1

Microbiote1

Pharmacovigilance1

Recommandations1

Sjögren1

Vascularites des gros vaisseaux1

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