📇 Rhumatologue · PARIS · (75) · Libéral

M VINCENT BORDERIE

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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 PARIS (75)LibéralRPPS 10000551571

📊 Reconnaissance scientifique : 43/100📝 512 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Tocilizumab versus Rituximab in Patients with Moderate to Severe Steroid-resistant Graves' Orbitopathy

Ocular immunology and inflammation · 2022

📚 21 citations🎯 RCR 2.82Top 17% NIH

Infectious keratitis following corneal transplantation: A long-term cohort study

Clinical & experimental ophthalmology · 2024

📚 15 citations🎯 RCR 5.75Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackgroundTo assess the long‐term incidence and risk factors for post‐keratoplasty infectious keratitis (IK), associated ocular pathogens, and antibiotic resistance profiles.MethodsCohort study including 2553 consecutive penetrating, endothelial, and anterior lamellar keratoplasties performed between 1992 and 2020. Medical and microbiological records of patients clinically diagnosed with IK were retrospectively reviewed. Main outcome measures: cumulative incidence of IK, infectious agent species, and antibiotics resistance profiles.ResultsThe average follow‐up time after transplantation was 112 ± 96 months. Eighty‐nine IK episodes were recorded; microbiological tests were positive in 55/89 (62%). The cumulated incidence of postoperative IK was 5.50%/10.25% at 10/20 years. The occurrence of at least one episode of IK after transplantation was associated with lower graft survival in the long term (p < 0.0001). Rejection risk (adjusted Hazard Ratio, 2.29) and postoperative epithelial complications (HR, 3.44) were significantly and independently associated with a higher incidence of postoperative IK. Infectious agents included 41 bacteria, 10 HSV, 6 fungi, and 1 Acanthamoeba. The rate of antibiotic resistance was 0% for vancomycin, 13% for fluoroquinolones, 20% for rifamycin, 59% for aminoglycosides, and 73% for ticarcillin. In 41% of cases, patients were under prophylactic topical antibiotics before the infectious episode. Topical antibiotics were significantly associated with increased resistance to penicillin, carbapenems, and aminoglycosides.ConclusionIK (mainly bacterial) is a frequent complication of corneal transplantation in the long term. Vancomycin and fluoroquinolones can be considered as first‐line treatments. Prolonged postoperative antibiotic preventive treatment is not advisable as it may increase antibiotic resistance.

Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism

Journal of clinical medicine · 2023

📚 12 citations🎯 RCR 3.13Top 15% NIH🔓 Open Access📄 PDF gratuit ↗

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The aim of this study was to assess Corvis ST biomechanical indices in reference to corneal enantiomorphism. In a prospective observational cohort study, 117 eyes from 63 patients with normal or keratoconus corneas were assessed by three independent observers. In the control group (n = 62), no significant differences were observed between the three observers for all indices. The best reproducibility was obtained with pachymetry and the weakest with CBI. All indices but CBI and arc length featured COV < 10%. All indices except the PD and SSI correlated with pachymetry; all but Rad correlated with IOP. The comparison of the thinnest with the thickest corneas showed no significant differences for any index except pachymetry. In the keratoconus group (n = 55), loss of corneal enantiomorphism was confirmed for all indices except the arc length, velocity, and PD. Significant differences between both groups were found for all indices, even after adjustment for pachymetry and intraocular pressure. The CBI featured the best accuracy (92%), sensitivity (91%), and graphical relevance for keratoconus diagnosis. However, its reproducibility was weak in normal corneas and was strongly dependent on corneal thickness. The SSI was independent of corneal thickness, highly reproducible, and provided the expected enantiomorphism characteristics in both groups, making it a relevant biomarker of biomechanical corneal behavior.

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M VINCENT BORDERIE

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Publications scientifiques (20) — classées par pathologie

Transversal9

Revue générale3

Biothérapies non-anti-TNF1

Case report / série1

Épidémiologie & registres1

Essai clinique1

Lupus1

Pharmacovigilance1

Qualité de vie / PROMs1

Revue / méta-analyse1

Vraie vie / RWE1

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