📇 Rhumatologue · CRETEIL CEDEX · (94) · Hospitalier

M Mickaël BONNAN

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3 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
43 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
134 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CRETEIL CEDEX (94)HospitalierRPPS 10001669521

📊 Reconnaissance scientifique : 18/100📝 92 articles publiés🇫🇷 Publications académiques françaises (5)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Short delay to initiate plasma exchange is the strongest predictor of outcome in severe attacks of NMO spectrum disorders

Journal of neurology, neurosurgery, and psychiatry · 2018

📚 240 citations🎯 RCR 13.85Top 1% NIH

Lire l'abstract Crossref ↓

Introduction Severe attacks of neuromyelitis optica spectrum disorder (NMO-SD) are improved by plasma exchange (PLEX) given as an adjunctive therapy. Initial studies failed to demonstrate a delay of PLEX treatment influenced clinical outcome; however PLEX was always used late. We examine the clinical consequences of delay in PLEX initiation on severe optic neuritis and spinal cord attacks in NMO-SD. Methods All of our patients who suffered attacks of NMO-SD, treated in our centre by PLEX, were retrospectively considered for inclusion. Primary outcome was defined as complete improvement. Secondary poor/good outcomes were respectively defined to be the higher/lower third of Delta-Expanded Disability Status Scale (EDSS) (late minus baseline EDSS). Delays from clinical onset to PLEX initiation were categorised for multivariate analysis. Results Of the 60 patients included, NMO-SD criteria (2015) were fulfilled in 92%. One hundred and fifteen attacks were included and received PLEX with a median of 7 days (0–54) after clinical onset. The probability to regain complete improvement continuously decreased from 50% for PLEX given at day 0 to 1%–5% after day 20. Through multivariate analysis, the baseline impairment and PLEX delay were associated with the probability to complete improvement (OR 5.3; 95% CI 1.8 to 15.9). Reducing the PLEX delay also influenced the good secondary outcome but not the poor secondary outcome. Conclusions These results confirm an improved clinical benefit of early initiation of PLEX during severe attacks of NMO-SD. Perceiving PLEX as a rescue therapy only after steroid failure could be deleterious.

Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study

Neurology · 2022

📚 119 citations🎯 RCR 12.33Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

Natural history of the visual impairment of relapsing neuromyelitis optica

Ophthalmology · 2007

📚 116 citations🎯 RCR 3.79Top 12% NIH

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M Mickaël BONNAN

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (43) — classées par pathologie

Transversal34

Case report / série4

Biothérapies non-anti-TNF2

Corticothérapie1

Épidémiologie & registres1

Revue générale1

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