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Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CENTRE DE REDUCATION LA CHATAIGNERAIE
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The New England journal of medicine · 2008
Clinical journal of the American Society of Nephrology : CJASN · 2009
Arthritis & rheumatology (Hoboken, N.J.) · 2016
Objective Findings from the WEGENT trial and other short‐term studies have suggested that azathioprine (AZA) or methotrexate (MTX) could effectively maintain remission of granulomatosis with polyangiitis (Wegener's) (GPA) or microscopic polyangiitis (MPA). This study was undertaken to examine whether differences in rates of relapse or adverse events would appear after discontinuation of these 2 maintenance regimens, when assessed over a longer followup period.MethodsLong‐term outcomes in patients enrolled in the WEGENT trial were analyzed according to their randomized treatment group (AZA or MTX). Parameters at trial entry were evaluated as potential prognostic factors for death, relapse, or damage in multivariate models.Results Data from 10 years of followup were available for 112 (88.8%) of the 126 original trial participants. The median followup time was 11.9 years (95% confidence interval [95% CI] 11.3–12.5 years). In patients receiving AZA and those receiving MTX, the 10‐year overall survival rates were 75.1% (95% CI 64.8–86.9%) and 79.9% (95% CI 70.3–90.8%) (P = 0.56), respectively, and relapse‐free survival rates were 26.3% (95% CI 17.3–40.1%) and 33.5% (95% CI 23.5–47.7%) (P = 0.29), respectively. No between‐treatment differences were observed with regard to rates of relapse, adverse events, damage, survival without severe side effects, and survival without relapse and severe side effects. In analyses limited to the 97 patients with GPA, no between‐treatment differences in survival rates were observed. The 10‐year relapse‐free survival rate was lower in patients with GPA than in patients with MPA. However, in the multivariate analysis, anti–proteinase 3 antineutrophil cytoplasmic antibody (ANCA) positivity, and not GPA, was retained as being independently associated with the relapse rate.ConclusionThe results of this long‐term analysis confirm that AZA and MTX are comparable treatment options for maintaining remission of GPA or MPA. Despite achieving good overall survival with these treatments, relapse rates, adverse events, and damage remain matters of concern and further studies are needed to reduce their frequency in these ANCA‐associated vasculitides.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Clinical kidney journal · 2024 · Journal Article
Lafargue MC, Duong Van Huyen JP, Rennke HG, Essig M, et al.
La Revue de medecine interne · 2023 · Journal Article
Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, et al.
La Revue de medecine interne · 2023 · Journal Article
Georgin-Lavialle S, Savey L, Buob D, Bastard JP, et al.
TH open : companion journal to thrombosis and haemostasis · 2022 · Journal Article
Van Meerhaeghe T, Cez A, Dahan K, Esteve E, et al.
Frontiers in immunology · 2019 · Journal Article
Marques C, Carvelli J, Biard L, Faguer S, et al.
Joint bone spine · 2017 · Journal Article
Philipponnet C, Garrouste C, Le Guenno G, Cartery C, et al.
Orphanet journal of rare diseases · 2013 · Journal Article
Stehlé T, Joly D, Vanhille P, Boffa JJ, et al.
La Revue de medecine interne · 2002 · Journal Article
Rossert J, Boffa JJ, Verhelst D
American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022 · Journal Article
Ronsin C, Georges M, Chapelet-Debout A, Augusto JF, et al.
Rheumatology (Oxford, England) · 2021 · Journal Article
Durel CA, Sinico RA, Teixeira V, Jayne D, et al.
RMD open · 2023 · Multicenter Study
Guedon AF, Ricard L, Laurent C, De Moreuil C, et al.
Journal of autoimmunity · 2022 · Multicenter Study
Rousselin C, Amoura Z, Faguer S, Bataille P, et al.
Autoimmunity reviews · 2022 · Journal Article
Scheen M, Adedjouma A, Esteve E, Buob D, et al.
BMJ case reports · 2019 · Case Reports
Serre J, Buob D, Boffa JJ
The New England journal of medicine · 2008 · Comparative Study
Pagnoux C, Mahr A, Hamidou MA, Boffa JJ, et al.
Joint bone spine · 2026 · Journal Article
Raymond A, Savadogo B, Bourguiba R, Dellal A, et al.
Leukemia & lymphoma · 2018 · Journal Article
Jachiet V, Mekinian A, Carrat F, Grignano E, et al.
Clinical journal of the American Society of Nephrology : CJASN · 2009 · Journal Article
Melander C, Sallée M, Trolliet P, Candon S, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012 · Journal Article
Kerroch M, Guerrot D, Vandermeersch S, Placier S, et al.
Nephrologie & therapeutique · 2009 · English Abstract
Boffa JJ, Rougier JP, Noël N, Ronco P
Rheumatology (Oxford, England) · 2019 · Letter
Dellal A, Bige N, Hilliquin P, Boffa JJ, et al.
La Revue du praticien · 2002 · English Abstract
Boffa JJ, Rossert J
Arthritis & rheumatology (Hoboken, N.J.) · 2016 · Comparative Study
Puéchal X, Pagnoux C, Perrodeau É, Hamidou M, et al.
The New England journal of medicine · 2008 · Comparative Study
Pagnoux C, Mahr A, Hamidou MA, Boffa JJ, et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation · 1998 · Case Reports
Messiaen T, M'bappé P, Boffa JJ, Khayat R, et al.
Joint bone spine · 2022 · Journal Article
Ricard L, Laurent C, Papo M, Deriaz S, et al.