📇 Rhumatologue · VANNES CEDEX · (56) · Salarié

MME Lorraine BLAISE

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17 articles scientifiques publiés — formation continue solide
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141.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 VANNES CEDEX (56)SalariéRPPS 10101185295

Publications actives

47 publications sur 5 ans

📊 Reconnaissance scientifique : 14/100📝 65 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Liver Stiffness by Transient Elastography to Detect Porto-Sinusoidal Vascular Liver Disease With Portal Hypertension

Hepatology (Baltimore, Md.) · 2021

📚 67 citations🎯 RCR 5.38Top 7% NIH

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Background and Aims Porto‐sinusoidal vascular liver disease (PSVD) is a rare cause of portal hypertension. PSVD is still often misdiagnosed as cirrhosis, emphasizing the need to improve PSVD diagnosis strategies. Data on liver stiffness measurement using transient elastography (TE‐LSM) in PSVD are limited. The aim of this study was to evaluate the accuracy of TE‐LSM to discriminate PSVD from cirrhosis in patients with signs of portal hypertension. Approach and Results Retrospective multicenter study comparing TE‐LSM in patients with PSVD, according to Vascular Liver Disease Interest Group criteria, with patients with compensated biopsy‐proven cirrhosis associated with alcohol (n = 117), HCV infection (n = 110), or NAFLD (n = 46). All patients had at least one sign of portal hypertension among gastroesophageal varices, splenomegaly, portosystemic collaterals, history of ascites, or platelet count < 150 × 109/L. The 77 patients with PSVD included in the test cohort had lower median TE‐LSM (7.9 kPa) than the patients with alcohol‐associated, HCV‐related, and NAFLD‐related cirrhosis (33.8, 18.2, and 33.6 kPa, respectively; P < 0.001). When compared with cirrhosis, a cutoff value of 10 kPa had a specificity of 97% for the diagnosis of PSVD with a 85% positive predictive value. A cutoff value of 20 kPa had a sensitivity of 94% for ruling out PSVD with a 97% negative predictive value. Of the patients, 94% were well‐classified. Even better results were obtained in a validation cohort including 78 patients with PSVD. Conclusions This study including a total of 155 patients with PSVD and 273 patients with cirrhosis demonstrates that TE‐LSM < 10 kPa strongly suggests PSVD in patients with signs of portal hypertension. Conversely, when TE‐LSM is >20 kPa, PSVD is highly unlikely.

Impact of COVID-19 on the management of hepatocellular carcinoma in a high-prevalence area

JHEP reports : innovation in hepatology · 2021

📚 65 citations🎯 RCR 3.95Top 11% NIH🔓 Open Access📄 PDF gratuit ↗

Comparison of Trans-Arterial Chemoembolization and Bland Embolization for the Treatment of Hepatocellular Carcinoma: A Propensity Score Analysis

Cancers · 2021

📚 20 citations🎯 RCR 1.41🔓 Open Access📄 PDF gratuit ↗

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No definitive conclusion could be reached about the role of chemotherapy in adjunction of embolization in the treatment of hepatocellular carcinoma (HCC). We aim to compare radiological response, toxicity and long-term outcomes of patients with hepatocellular carcinoma (HCC) treated by trans-arterial bland embolization (TAE) versus trans-arterial chemoembolization (TACE). We retrospectively included 265 patients with HCC treated by a first session of TACE or TAE in two centers. Clinical and biological features were recorded before the treatment and radiological response was assessed after the first treatment using modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. Correlation between the treatment and overall, progression-free and transplantation-free survival was performed after adjustment using a propensity score matching: 86 patients were treated by bland embolization and 179 patients by TACE, including 44 patients with drug-eluting beads and 135 with lipiodol TACE, 89.8% of patients were male with a median age of 65 years old. Cirrhosis was present in 90.9% of patients with a Child Pugh score A in 84% of cases. After adjustment, no difference in the rate of AE, including liver failure, was observed between the two treatments. TACE was associated with a significant increase in complete radiological response (odds ratio (OR) = 8.5 (95% confidence interval (CI): 2.8–25.4)) but not in the overall response rate (OR = 2.2 (95% CI = 0.8–5.8)). No difference in terms of overall survival (p = 0.3905), progression-free survival (p = 0.4478) and transplantation-free survival (p = 0.9020) was observed between TACE and TAE. TACE was associated with a higher rate of complete radiological response but without any impact on overall radiological response, progression-free survival and overall survival compared to TAE.

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MME Lorraine BLAISE

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (17) — classées par pathologie

Transversal10

Épidémiologie & registres4

Vraie vie / RWE2

Microbiote1

Pharmacovigilance1

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