Docteur SAMUEL BITOUN
✨ Profil synthétique
IA · 04/05/2026Le Docteur Samuel Bitoun est un rhumatologue hospitalier à Le Kremlin-Bicêtre, avec une expérience de recherche dans le domaine de la rhumatologie, notamment sur la polyarthrite rhumatoïde et le lupus érythémateux systémique. Ses travaux de recherche ont également porté sur les biothérapies et les maladies auto-immunes. Il a dirigé des travaux de recherche et a publié de nombreux articles dans des revues scientifiques.
Expertises présumées
- Polyarthrite rhumatoïde
- Lupus érythémateux systémique
- Sjögren
- Biothérapies non-anti-TNF
- Thérapies anti-TNF
- Épidémiologie en rhumatologie
- Intelligence artificielle en rhumatologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
📝 Autres formations
- Cancérologie, option Traitements médicaux des cancers
- Cancérologie, option Traitements médicaux des cancers (DNQ)
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
15
h articles cités ≥ h fois chacun. Un h de 15 = 15 publications avec 15+ citations.
Citations
787
Publications
87
i10-index
18
Thématiques principales
- Rheumatoid Arthritis Research and Therapies ×32
- Systemic Lupus Erythematosus Research ×16
- Cancer Immunotherapy and Biomarkers ×11
- Salivary Gland Disorders and Functions ×10
- Monoclonal and Polyclonal Antibodies Research ×9
Affiliations FR : Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Université Paris-Saclay
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
2025ArticleThe Lancet Rheumatology
CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
2025ArticleThe Lancet Rheumatology
Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines
2025ArticleClinical and Experimental Immunology
Do SMS/e-mail reminders increase influenza vaccination of rheumatoid arthritis patients under anti-TNF: a nested randomized controlled trial in the ART e-cohort
2024ArticleRheumatology
Complete remission after a single bisphosphonate infusion in isolated bone Langerhans cell histiocytosis lesion: a case report and a narrative review of the literature
2024ArticleJBMR Plus
Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis
2023ArticleRheumatology
Deep Learning Accurately Predicts Focus Score and Diagnosis of Primary Sjögren Syndrome Using Labial Salivary Gland Biopsies
2023CongrèsACR Convergence 2023
Response to Biologic Drugs in Patients with Rheumatoid Arthritis and Antidrug Antibodies
2023ArticleJAMA Network Open
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Livres & ouvrages
Source : Google Books — filtre catégories médicales/santé/sciences.
Lieu de consultation
GHU APHP UPS SITE KREMLIN BICETRE APHP
78 Avenue DU GENERAL LECLERC, 94275 Le Kremlin-Bicêtre
☎ 0145212121Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease
Med (New York, N.Y.) · 2021
📚 95 citations🎯 RCR 6.52Top 5% NIH🔓 Open Access - 2Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseases
Arthritis & rheumatology (Hoboken, N.J.) · 2022
📚 71 citations🎯 RCR 4.76Top 8% NIH🔓 Open AccessLire l'abstract Crossref ↓
ObjectiveAntibody response to the messenger RNA (mRNA) COVID‐19 vaccine has been shown to be diminished in rituximab (RTX)–treated patients. We undertook this study to compare humoral and T cell responses between healthy controls, patients with autoimmune diseases treated with RTX, and those treated with other immunosuppressants, all of whom had been vaccinated with 2 doses of the mRNA COVID‐19 vaccine.MethodsWe performed anti‐spike IgG and neutralization assays just before and 28 days after the second BNT162b2 (Pfizer‐BioNTech) vaccine dose. The specific T cell response was assessed in activated CD4 and CD8 T cells using intracellular flow cytometry staining of cytokines (interferon‐γ, tumor necrosis factor, and interleukin‐2) after stimulation with SARS–CoV‐2 spike peptide pools.ResultsA lower proportion of responders with neutralizing antibodies to the vaccine was observed in the RTX group (29%; n = 24) compared to the other immunosuppressants group (80%; n = 35) (P = 0.0001) and the healthy control group (92%; n = 26) (P < 0.0001). No patients treated with RTX in the last 6 months showed a response. Time since last infusion was the main factor influencing humoral response in RTX‐treated patients. The functional CD4 and CD8 cellular responses to SARS–CoV‐2 peptides for each single cytokine or polyfunctionality were not different in the RTX group compared to the other immunosuppressants group or the control group. In RTX‐treated patients, the T cell response was not different between patients with and those without a humoral response.ConclusionRTX induced a diminished antibody response to the mRNA COVID‐19 vaccine, but the functional T cell response was not altered compared to healthy controls and autoimmune disease patients treated with other immunosuppressants. Further work is needed to assess the clinical protection granted by a functionally active T cell response in the absence of an anti‐spike antibody response.
- 3Treatment of neurosarcoidosis: A comparative study of methotrexate and mycophenolate mofetil
Neurology · 2016
📚 71 citations🎯 RCR 3.66Top 12% NIH
Publications scientifiques (41) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal24
▼
Transversal24
▼- Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives
Autoimmunity reviews · 2026 · Journal Article
Larue M, Bitoun S, Zuber J, Michel M, et al.
- Homozygosity for rare or common hypomorphic IL23R variants confers a predisposition to tuberculosis in humans
bioRxiv : the preprint server for biology · 2026 · Journal Article
Calderón DO, Kilpatrick LE, Conil C, Philippot Q, et al.
- Immune checkpoint inhibitor-induced joint involvement
Presse medicale (Paris, France : 1983) · 2026 · Journal Article
Quelain J, Henry J, Belkhir R, Mariette X, et al.
- Macrophage Cell Culture and Characterization by Serum Human AB in Health and Disease
Methods in molecular biology (Clifton, N.J.) · 2026 · Journal Article
Paoletti A, Ly B, Bitoun S, Nocturne G, et al.
- Sicca induced by immune checkpoint inhibitors
Presse medicale (Paris, France : 1983) · 2025 · Journal Article
Belkhir R, Gosset M, Rousseau A, Bitoun S, et al.
- Cluster analysis identifies three clinical patterns of patients with systemic autoimmune diseases and anti-Ku antibodies
RMD open · 2025 · Journal Article
Robert M, Nguyen Y, Allenbach Y, Sacre K, et al.
- CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
The Lancet. Rheumatology · 2025 · Journal Article
Scherlinger M, Nocturne G, Radic M, Launay D, et al.
📚 28 cit.🎯 RCR 10.18🔬→🩺 Translationnel - Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines
Clinical and experimental immunology · 2025 · Journal Article
Naigeon M, Bitoun S, Roulleaux Dugage M, de Oliveira C, et al.
- 2024 EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer
Annals of the rheumatic diseases · 2024 · Journal Article
Sebbag E, Lauper K, Molina-Collada J, Aletaha D, et al.
📚 21 cit.🎯 RCR 4.79🔬→🩺 Translationnel - Clonal CD8(+) T-cell expansion is associated with complete response to elranatamab in refractory multiple myeloma
Haematologica · 2024 · Letter
Krzysiek R, Bitoun S, Belkhir R, Hacein-Bey-Abina S, et al.
📚 2 cit. - High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture
Bone reports · 2024 · Journal Article
Chevalier K, Hamroun S, Bitoun S, Henry J, et al.
📚 1 cit. - Immune Checkpoint Inhibitor-induced Inflammatory Arthritis: Current Approaches to Management
Rheumatic diseases clinics of North America · 2024 · Journal Article
Singh N, Shahane A, Sparks JA, Bitoun S, et al.
📚 6 cit.🎯 RCR 1.16 - Immune checkpoint inhibitor rechallenge in patients who previously experienced immune-related inflammatory arthritis: a multicentre observational study
RMD open · 2023 · Observational Study
Ladouceur A, Barnetche T, Mouterde G, Tison A, et al.
📚 5 cit.🩺 Clinique - Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies
JAMA network open · 2023 · Journal Article
Bitoun S, Hässler S, Ternant D, Szely N, et al.
📚 24 cit.🎯 RCR 3.61🔬→🩺 Translationnel - Using Autoantibodies to Diagnose Systemic Autoimmune Diseases Triggered by Immune Checkpoint Inhibitors: A Clinical Perspective
Critical reviews in immunology · 2022 · Review
Flores-Chávez A, Brito-Zerón P, Retamozo S, Bitoun S, et al.
📚 3 cit. - Response to COVID-19 mRNA vaccination in multiple myeloma is conserved but impaired compared to controls
Journal of hematology & oncology · 2021 · Letter
Bitoun S, Henry J, Vauloup-Fellous C, Dib N, et al.
📚 27 cit.🎯 RCR 1.36🔬→🩺 Translationnel - Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease
Med (New York, N.Y.) · 2021 · Journal Article
Matei DE, Menon M, Alber DG, Smith AM, et al.
📚 95 cit.🎯 RCR 6.52🔬→🩺 Translationnel - Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases
Haematologica · 2021 · Case Reports
Vergneault H, Bengoufa D, Frazier-Mironer A, Brocheriou I, et al.
📚 2 cit. - Rheumatology residency in France: an assessment of the past and the unknowns of a new reform
Joint bone spine · 2019 · Editorial
Fogel O, Bitoun S, young rheumatologist's (REF) section of the French Society of Rheumatology, (SFR)
📚 1 cit. - Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry
Frontiers in immunology · 2019 · Clinical Trial
Leite Pereira A, Bitoun S, Paoletti A, Nocturne G, et al.
📚 12 cit.🩺 Clinique - Valine 11 and phenylalanine 13 have a greater impact on the T-cell response to citrullinated peptides than the 70-74 shared epitope of the DRB1 molecule in macaques
Annals of the rheumatic diseases · 2019 · Journal Article
Bitoun S, Roques P, Maillere B, Le Grand R, et al.
📚 5 cit. - Frequency of tumour necrosis factor alpha receptor superfamily 1A multiple sclerosis-associated variants in patients with rheumatoid arthritis with anti-tumour necrosis factor therapy-related demyelinating complications
Annals of the rheumatic diseases · 2018 · Letter
Bitoun S, Miceli-Richard C, Verstuyft C, Juge PA, et al.
📚 4 cit. - Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque
Frontiers in immunology · 2017 · Journal Article
Bitoun S, Roques P, Larcher T, Nocturne G, et al.
📚 8 cit. - Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis
European journal of pharmacology · 2013 · Journal Article
Kireev R, Bitoun S, Cuesta S, Tejerina A, et al.
📚 54 cit.🎯 RCR 2.33
csDMARDs5
▼
csDMARDs5
▼- Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis
Rheumatology (Oxford, England) · 2023 · Journal Article
Duquesne J, Bouget V, Cournède PH, Fautrel B, et al.
📚 21 cit.🎯 RCR 3.66🔬→🩺 Translationnel - Clinically effective concentration and risk of hydroxychloroquine retinopathy in systemic lupus erythematosus: walking on a thin line. Comment on the article by Garg et al
Arthritis care & research · 2022 · Letter
Bitoun S, Nocturne G, Seror R, Mariette X
- Interaction between B-cell activation factor and methotrexate impacts immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis
Annals of the rheumatic diseases · 2019 · Letter
Park JK, Lee YJ, Bitoun S, Winthrop KL, et al.
📚 17 cit.🩺 Clinique - Methotrexate and BAFF interaction prevents immunization against TNF inhibitors
Annals of the rheumatic diseases · 2018 · Journal Article
Bitoun S, Nocturne G, Ly B, Krzysiek R, et al.
📚 28 cit.🎯 RCR 1.20🔬→🩺 Translationnel - Treatment of neurosarcoidosis: A comparative study of methotrexate and mycophenolate mofetil
Neurology · 2016 · Comparative Study
Bitoun S, Bouvry D, Borie R, Mahevas M, et al.
📚 71 cit.🎯 RCR 3.66🔬→🩺 Translationnel
Sjögren4
▼
Sjögren4
▼- Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
The Lancet. Rheumatology · 2025 · Journal Article
Duquesne J, Basseto L, Claye C, Barnes M, et al.
📚 4 cit. - Association between anti-SSA/SSB antibody profiles and patient-reported outcomes in primary Sjögren's disease
Rheumatology (Oxford, England) · 2025 · Journal Article
Robert M, Nguyen Y, Belkhir R, Desmoulins F, et al.
- Immune Checkpoint Inhibitor-induced Sicca Syndrome
Rheumatic diseases clinics of North America · 2024 · Journal Article
Bitoun S, Rousseau A, Gosset M, Belkhir R, et al.
📚 4 cit. - Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52
Biothérapies non-anti-TNF3
▼
Biothérapies non-anti-TNF3
▼- Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52 - Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseases
Arthritis & rheumatology (Hoboken, N.J.) · 2022 · Journal Article
Bitoun S, Henry J, Desjardins D, Vauloup-Fellous C, et al.
📚 71 cit.🎯 RCR 4.76🔬→🩺 Translationnel - Very low rate of humoral response after a third COVID-19 vaccine dose in patients with autoimmune diseases treated with rituximab and non-responders to two doses
RMD open · 2022 · Letter
Bitoun S, Avouac J, Henry J, Ghossan R, et al.
📚 14 cit.🔬→🩺 Translationnel
IA en rhumatologie3
▼
IA en rhumatologie3
▼- Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
The Lancet. Rheumatology · 2025 · Journal Article
Duquesne J, Basseto L, Claye C, Barnes M, et al.
📚 4 cit. - Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis
Rheumatology (Oxford, England) · 2023 · Journal Article
Duquesne J, Bouget V, Cournède PH, Fautrel B, et al.
📚 21 cit.🎯 RCR 3.66🔬→🩺 Translationnel - Machine learning predicts response to TNF inhibitors in rheumatoid arthritis: results on the ESPOIR and ABIRISK cohorts
RMD open · 2022 · Journal Article
Bouget V, Duquesne J, Hassler S, Cournède PH, et al.
📚 17 cit.🎯 RCR 1.76🔬→🩺 Translationnel
Anti-TNF2
▼
Anti-TNF2
▼- Restoration of Default Blood Monocyte-Derived Macrophage Polarization With Adalimumab But Not Etanercept in Rheumatoid Arthritis
Frontiers in immunology · 2022 · Journal Article
Paoletti A, Ly B, Bitoun S, Nocturne G, et al.
📚 9 cit. - Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells
Frontiers in immunology · 2022 · Journal Article
de Bourayne M, Meunier S, Bitoun S, Correia E, et al.
📚 16 cit.🎯 RCR 1.36🔬→🩺 Translationnel
Épidémiologie & registres1
▼
Épidémiologie & registres1
▼- Prophylaxis with tixagevimab/cilgavimab is associated with lower COVID-19 incidence and severity in patients with autoimmune diseases
Rheumatology (Oxford, England) · 2024 · Journal Article
Thomas M, Masson M, Bitoun S, Hamroun S, et al.
📚 5 cit.🩺 Clinique
Lupus1
▼
Lupus1
▼- Clinically effective concentration and risk of hydroxychloroquine retinopathy in systemic lupus erythematosus: walking on a thin line. Comment on the article by Garg et al
Arthritis care & research · 2022 · Letter
Bitoun S, Nocturne G, Seror R, Mariette X
Ostéoporose1
▼
Ostéoporose1
▼- Complete remission after a single bisphosphonate infusion in isolated bone Langerhans cell histiocytosis lesion: a case report and a narrative review of the literature
JBMR plus · 2024 · Case Reports
Kachaner A, Seror R, Aubart FC, Henry J, et al.
Revue / méta-analyse1
▼
Revue / méta-analyse1
▼- Systematic literature review and meta-analysis informing the EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer
Annals of the rheumatic diseases · 2025 · Journal Article
Sebbag E, Molina-Collada J, Ndoye R, Aletaha D, et al.
📚 10 cit.🎯 RCR 4.40🔬→🩺 Translationnel
Revue générale1
▼
Revue générale1
▼- Systematic literature review and meta-analysis informing the EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer
Annals of the rheumatic diseases · 2025 · Journal Article
Sebbag E, Molina-Collada J, Ndoye R, Aletaha D, et al.
📚 10 cit.🎯 RCR 4.40🔬→🩺 Translationnel
Datasets & protocoles partagés
Response to COVID-19 mRNA vaccination in multiple myeloma is conserved but impaired compared to controls
Collection2021figshareAbstract Patients with multiple myeloma are at high risk of severe forms of COVID-19. Despite data showing diminished response to vaccine, the era of highly efficient mRNA vaccine might be a gamechanger. We sought to exa
Response to COVID-19 mRNA vaccination in multiple myeloma is conserved but impaired compared to controls
Collection2021figshareAbstract Patients with multiple myeloma are at high risk of severe forms of COVID-19. Despite data showing diminished response to vaccine, the era of highly efficient mRNA vaccine might be a gamechanger. We sought to exa
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
