📇 Rhumatologue · COLOMBEY LES DEUX EGLISES · (52) · Libéral

MME CLARISSE BILLETTE-CHARBAUT

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Auteur de référence en rhumatologie
37 articles scientifiques publiés — un praticien à la pointe de la recherche
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85.7 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 COLOMBEY LES DEUX EGLISES (52)LibéralRPPS 10001736163

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR CLARISSE BILLETTE-CHARBAUT
CABINET MEDICAL 72 RUE DU GENERAL DE GAULLE, 52330 COLOMBEY LES DEUX EGLISES
☎ 0325353826Activité de soin et de pharmacie

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Top publications · les plus citées

F18-Choline PET/CT or MIBI SPECT/CT in the Surgical Management of Primary Hyperparathyroidism: A Diagnostic Randomized Clinical Trial

JAMA otolaryngology-- head & neck surgery · 2024

📚 23 citations🎯 RCR 10.35Top 2% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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ImportanceWhether F18-choline (FCH) positron emission tomographic (PET)/computed tomographic (CT) scan can replace Tc99m-sestaMIBI (MIBI) single-photon emission (SPE)CT/CT as a first-line imaging technique for preoperative localization of parathyroid adenomas (PTA) in patients with primary hyperparathyroidism (PHPT) is unclear.ObjectiveTo compare first-line FCH PET/CT vs MIBI SPECT/CT for optimal care in patients with PHPT needing parathyroidectomy and to compare the proportions of patients in whom the first-line imaging method resulted in successful minimally invasive parathyroidectomy (MIP) and normalization of calcemia 1 month after surgery.Design, Setting, and ParticipantsA French multicenter randomized open diagnostic intervention phase 3 trial was conducted. Patients were enrolled from November 2019 to May 2022 and participated up to 6 months after surgery. The study included adults with PHPT and an indication for surgical treatment. Patients with previous parathyroid surgery or multiple endocrine neoplasia type 1 (MEN1) were ineligible.InterventionsPatients were assigned in a 1:1 ratio to receive first-line FCH PET/CT (FCH1) or MIBI SPECT/CT (MIBI1). In the event of negative or inconclusive first-line imaging, they received second-line FCH PET/CT (FCH2) after MIBI1 or MIBI SPECT/CT (MIBI2) after FCH1. All patients underwent surgery under general anesthesia within 12 weeks following the last imaging. Clinical and biologic (serum calcemia and parathyroid hormone levels) assessments were performed 1 and 6 months after surgery.Main Outcomes and MeasuresThe primary outcome was a true-positive first-line imaging-guided MIP combined with uncorrected serum calcium levels of 2.55 mmol/l or less 1 month after surgery, corresponding to the local upper limit of normality.ResultsOverall, 57 patients received FCH1 (n = 29) or MIBI1 (n = 28). The mean (SD) age of patients was 62.8 (12.5) years with 15 male (26%) and 42 female (74%) patients. Baseline patient characteristics were similar between groups. Normocalcemia at 1 month after positive first-line imaging-guided MIP was observed in 23 of 27 patients (85%) in the FCH1 group and 14 of 25 patients (56%) in the MIBI1 group. Sensitivity was 82% (95% CI, 62%-93%) and 63% (95% CI, 42%-80%) for FCH1 and MIBI1, respectively. Follow-up at 6 months with biochemical measures was available in 43 patients, confirming that all patients with normocalcemia at 1 month after surgery still had it at 6 months. No adverse events related to imaging and 4 adverse events related to surgery were reported.ConclusionsThis randomized clinical trial found that first-line FCH PET/CT is a suitable and safe replacement for MIBI SPECT/CT. FCH PET/CT leads more patients with PHPT to correct imaging-guided MIP and normocalcemia than MIBI SPECT/CT thanks to its superior sensitivity.Trial RegistrationClinicalTrials.gov Identifier: NCT04040946

Olaparib, Temozolomide, and Concomitant Radiotherapy for Partially Resected or Biopsy-Only Glioblastoma First-Line Treatment: Results from the OLA-TMZ-RTE-01 Phase I Study

Clinical cancer research : an official journal of the American Association for Cancer Research · 2025

📚 10 citations🎯 RCR 3.80🩺 Clinique

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Abstract Purpose: Radiochemotherapy remains the mainstay of glioblastoma (GBM) first-line treatment after extended surgery, but the prognosis is still poor. PARP inhibitors like olaparib may improve GBM outcomes. We implemented a phase I to IIa trial to assess the safety and efficacy of olaparib combined with standard radiochemotherapy as a first-line treatment in patients with unresected GBM. We herein present results of phase I. Patients and Methods: Based on the Stupp regimen, two sequential dose escalations of olaparib were performed to distinguish the radiotherapy period and the maintenance period for assessing the MTD of olaparib separately for each treatment period. Dose escalations were performed by a Time-to-Event Continual Reassessment Method. Results: A total of 30 patients were enrolled: 20 (66.7%) men, median age 59 years (range, 25–70), and 12 patients (42.9%) with Eastern Cooperative Oncology Group performance status of 0. Among them, 16 and 11 patients were assessable for determining MTD in each period. Hematologic dose-limiting toxicities were experienced by four and one patients in each sequential dose escalation, respectively. The MTD was olaparib 100 mg twice daily for 3 days a week in concomitant during both the radiochemotherapy and maintenance periods of the standard treatment. The median progression-free and overall survival were 6.2 and 19.8 months, respectively. The 2-year survival rate was 36.7% (22.9–58.7). Conclusions: Intermittent dosing of olaparib at radiosensitizing concentrations in concomitant with the Stupp protocol has an acceptable safety profile with promising outcomes in patients with unresectable GBM. Further efficacy determination is ongoing in the phase IIa step.

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression

Metabolism: clinical and experimental · 2025

📚 8 citations🎯 RCR 3.28🔓 Open Access

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MME CLARISSE BILLETTE-CHARBAUT

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Publications scientifiques (37) — classées par pathologie

Essai clinique12

Transversal8

Case report / série3

Corticothérapie3

Vraie vie / RWE3

Épidémiologie & registres2

Qualité de vie / PROMs2

Santé mentale / fatigue2

Gériatrie1

Lupus1

Microbiote1

Pédiatrie1

Pharmacovigilance1

Revue générale1

SAPL1

Vascularites des gros vaisseaux1

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