📇 Rhumatologue · PARIS · (75) · Hospitalier
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Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Disponibilité géographique
3 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
4
4 articles ont été cités au moins 4fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
1 041
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
7
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
4
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Centre National de la Recherche Scientifique · Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CDS ESPACE SANTE DENFERT
3 PL DENFERT ROCHEREAU, 75014 PARIS
GHU APHP UPS SITE PAUL BROUSSE
12-14 12 AV PAUL VAILLANT COUTURIER BP 200, 94804 VILLEJUIF CEDEX
CSAPA ITHAQUE
9 R GEORGES BIZET, 94800 VILLEJUIF
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Le Monde.fr · 12/02/2025
<a href="https://news.google.com/rss/articles/CBMiiwJBVV95cUxQb0hERE53dkYyX3Rua3pkOUNLZ1RfR21NNUNCREZ4dkRrX0VVeTJFSExmVjJsZE1hN2RfeDJON3V5Vml6Y3E1ZmZhdE5TMFJ6d2lCeWhPNVkzYzVvaW40M1pIU3NfejNyRVNSZHVLNHdsVHhqSW81T3hIQ0NRSVNrQjNoV2xfQWNZRDJxeW9WVDdNX3c3ZzZ4VEdXSXhVY09DX1pzN1RwNEd4VGZmVUxDWjhTTU96c0tHcW
Circulation · 2005
Background— The prevalence of white matter hyperintensities (WMHs) detected on cerebral MRI is associated with hypertension, but it is not known whether blood pressure lowering can arrest their progression. We report here the results of an MRI substudy of PROGRESS (Perindopril Protection Against Recurrent Stroke Study), a randomized trial of blood pressure lowering in subjects with cerebrovascular disease. Methods and Results— The substudy comprised 192 participants who had a cerebral MRI both at baseline and after a mean follow-up time of 36 months (SD=6.0 months). At the first MRI, WMHs were graded with a visual rating scale from A (no WMH) to D (severe WMH). Participants were assigned to a combination of perindopril plus indapamide (or their placebos; 58%) or to single therapy with perindopril (or placebo). At the time of the second MRI, the blood pressure reduction in the active arm compared with the placebo arm was 11.2 mm Hg for systolic blood pressure and 4.3 mm Hg for diastolic blood pressure. Twenty-four subjects (12.5%) developed new WMHs at follow-up. The risk of new WMH was reduced by 43% (95% CI −7% to 89%) in the active treatment group compared with the placebo group ( P =0.17). The mean total volume of new WMHs was significantly reduced in the active treatment group (0.4 mm 3 [SE=0.8]) compared with the placebo group (2.0 mm 3 [SE=0.7]; P =0.012). This difference was greatest for patients with severe WMH at entry, 0.0 mm 3 (SE=0) in the active treatment group versus 7.6 mm 3 (SE=1.0) in the placebo group ( P <0.0001). Conclusions— These results indicate that an active blood pressure–lowering regimen stopped or delayed the progression of WMHs in patients with cerebrovascular disease.
Cerebrovascular diseases (Basel, Switzerland) · 2002
<i>Background and Purpose:</i> White matter hyperintensities (WMHs) are often observed on cerebral magnetic resonance imaging (MRI) of elderly individuals. Epidemiological studies have shown that age and hypertension are associated with WMHs, suggesting a vascular mechanism in WMH pathogenesis. In a population-based prospective study, we examined the association of carotid atherosclerosis measured at baseline and 4-year follow-up with severity of WMHs assessed at 4-year follow-up. <i>Methods: </i>The sample consisted of 640 healthy subjects aged 59–71 years at entry enrolled in the prospective EVA Study. Systolic and diastolic blood pressures were measured at each wave. Ultrasonographic measures of intima-media thickness (IMT) of the common carotid arteries and plaques were made at baseline and at 4-year follow-up examination. An MRI examination was performed at 4-year follow-up. The presence and severity of WMHs were evaluated by a single radiologist. <i>Results:</i> After adjusting for age, gender, and hypertension, the presence of carotid plaques at baseline was significantly associated with the presence of severe WMHs 4 years later [odds ratio (OR) = 1.70; 95% confidence interval (CI): 1.05–2.74]. The association was stronger in men than in women. A 0.1-mm increase of baseline IMT was associated with an increased risk of severe WMHs in both sexes (adjusted OR = 1.17; 95% CI: 0.96–1.41), but the association was not significant (p = 0.12). Cross-sectional relationships between carotid plaques and severe WMHs at 4-year follow-up showed that the risk of having severe WMHs was stronger in the group of subjects who had already plaques at study entry compared to the group of subjects whose plaques occurred during 4-year follow-up. <i>Conclusion:</i> This study confirmed an association between carotid atherosclerosis and WMHs independently of age and hypertension. It also suggested that the older the carotid plaques, the higher the risk of having severe WMHs.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Circulation · 2005 · Journal Article
Dufouil C, Chalmers J, Coskun O, Besançon V, et al.
Cerebrovascular diseases (Basel, Switzerland) · 2002 · Comparative Study
Pico F, Dufouil C, Lévy C, Besançon V, et al.