M Francis BERTRAND

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

• BRain-D: A quality-controlled methodology for constructing the BRazilian Daily rainfall gridded data

  2026

  ArticleAtmospheric Research

• Uncovering Rainfall Trend Discrepancies in Brazil (1983–2022): Insights From Ground‐Based and Blended Datasets

  2025

  ArticleInternational Journal of Climatology

• Evaluation of Machine Learning Models to Improve Daily Precipitation Estimations From Orbital Remote Sensing and Reanalysis Data

  2025

  ArticleInternational Journal of Climatology

• The design of the Brazilian Sub-Daily Rainfall dataset (BR-SDR): two decades of high-time-resolution data in Brazil

Lieu de consultation

• Remplaçant

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  [Gamma heavy chain disease associated with rheumatoid arthritis. Spontaneous disappearance of the pathologic protein]

  La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1977

  📚 15 citations
• 2

  HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

  International journal of molecular sciences · 2020

  📚 13 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  HIV-1 infection is frequently associated with low bone density, which can progress to osteoporosis leading to a high risk of fractures. Only a few mechanisms have been proposed to explain the enhanced osteolysis in the context of HIV-1 infection. As macrophages are involved in bone homeostasis and are critical host cells for HIV-1, we asked whether HIV-1-infected macrophages could participate in bone degradation. Upon infection, human macrophages acquired some osteoclast features: they became multinucleated, upregulated the osteoclast markers RhoE and β3 integrin, and organized their podosomes as ring superstructures resembling osteoclast sealing zones. However, HIV-1-infected macrophages were not fully differentiated in osteoclasts as they did not upregulate NFATc-1 transcription factor and were unable to degrade bone. Investigating whether infected macrophages participate indirectly to virus-induced osteolysis, we showed that they produce RANK-L, the key osteoclastogenic cytokine. RANK-L secreted by HIV-1-infected macrophages was not sufficient to stimulate multinucleation, but promoted the protease-dependent migration of osteoclast precursors. In conclusion, we propose that, by stimulating RANK-L secretion, HIV-1-infected macrophages contribute to create a microenvironment that favors the recruitment of osteoclasts, participating in bone disorders observed in HIV-1 infected patients.

Publications scientifiques (3) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• Sauvé des eaux, sauvé du temps : la science au service du patrimoine. Francis Bertrand (ARC-Nucléart)

  Audiovisual2013Musée d'Archéologie du Jura

  En 2013, le musée d'archéologie du Jura propose l'exposition Sauvé des eaux, sauvé du temps. La muséographie de l’exposition s’appuie en grande partie sur un contenu scientifique conçu par le laboratoire ARC-Nucléart. Im

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

Partager cette fiche