📇 Rhumatologue · BEAUVAIS CEDEX · (60) · Salarié
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2 raisons identifiées
Auteur de référence en rhumatologie
47 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
73.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CH BEAUVAIS
40 AV LÉON BLUM BP 40 319, 60021 BEAUVAIS CEDEX
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Journal of hepatology · 2014
Infection and immunity · 2009
ABSTRACTThe pathogenesis of cryptococcosis, including the events leading to the production of meningoencephalitis, is still largely unknown. Evidence of a transcellular passage ofCryptococcus neoformansacross the blood-brain barrier (BBB) and subsequent BBB disruption exists, but the paracellular passage of free yeasts and the role of monocytes in yeast dissemination and brain invasion (Trojan horse method) remain uncertain. We used our model of disseminated cryptococcosis, in which crossing of the BBB starts 6 h after intravenous inoculation, to study paracellular passage of the BBB. We prepared bone marrow-derived monocytes (BMDM) infected in vitro withC. neoformans(BMDM yeasts) and free yeasts and measured fungal loads in tissues. (i) Spleen and lung CFU were >2-fold higher in mice treated with BMDM yeasts than in those treated with free yeasts for 1 and 24 h (P< 0.05), while brain CFU were increased (3.9 times) only at 24 h (P< 0.05). (ii) By comparing the kinetics of brain invasion in naïve mice and in mice with preestablished cryptococcosis, we found that CFU were lower in the latter case, except at 6 h, when CFU from mice inoculated with BMDM yeasts were comparable to those measured in naïve mice and 2.5-fold higher than those in mice with preestablished cryptococcosis who were inoculated with free yeasts. (iii) Late phagocyte depletion obtained by clodronate injection reduced disease severity and lowered the fungal burden by 40% in all organs studied. These results provide evidence for Trojan horse crossing of the BBB byC. neoformans, together with mechanisms involving free yeasts, and overall for a role of phagocytes in fungal dissemination.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
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Tiwary T, B V, C R
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Progress in transplantation (Aliso Viejo, Calif.) · 2020 · Letter
Blackstock D, Butler L, Delair S, Dokus K, et al.
Journal of the American Medical Directors Association · 2020 · Letter
Camille S, Patrick H, Clarisse D, Charifa N, et al.
Current computer-aided drug design · 2020 · Journal Article
M S, B P, Swaminathan P
Clinica chimica acta; international journal of clinical chemistry · 2019 · Journal Article
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Cell death & disease · 2018 · Journal Article
Liang QX, Wang ZB, Lin F, Zhang CH, et al.
International journal of biological macromolecules · 2018 · Journal Article
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Oncotarget · 2015 · Journal Article
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Journal of hepatology · 2014 · Journal Article
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Sonnet C, Lafuste P, Arnold L, Brigitte M, et al.
Food additives and contaminants · 2005 · Journal Article
Juhel-Gaugain M, Fourmond MP, Delepine B, Laurentie M, et al.
Revue neurologique · 2004 · English Abstract
Godefroy O, Brigitte A, Philippe A, Mira DH, et al.
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Zhang Y, Brigitte S
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Derouane F, Brigitte H, Placide N
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Acta clinica Belgica · 2021 · Case Reports
Derouane F, Brigitte H, Placide N
Case reports in obstetrics and gynecology · 2017 · Case Reports
Andre N, Juliette NUME, Fokom Domgue J, Brigitte W, et al.
Contact dermatitis · 2025 · Case Reports
Miranda L, Oriane LL, Nour N, Pierre S, et al.
Case reports in obstetrics and gynecology · 2017 · Case Reports
Andre N, Juliette NUME, Fokom Domgue J, Brigitte W, et al.
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Pandarathodiyil AK, Kasirajan HS, Vemuri S, Sujai GVNS, et al.
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Infant mental health journal · 2021 · Journal Article
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