📇 Rhumatologue · LIVRY GARGAN · (93) · Salarié

M TOUFIK BENMOUFFOK-SAID

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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche
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78.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LIVRY GARGAN (93)SalariéRPPS 10001562312

✨ Génération du profil synthétique IA en cours…

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CDS MEDICO-DENTAIRE CHANZY
4 ALL FAIDHERBE, 93190 LIVRY GARGAN
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Top publications · les plus citées

Telesurgery's potential role in improving surgical access in Africa

Annals of medicine and surgery (2012) · 2022

📚 21 citations🎯 RCR 3.05Top 16% NIH🔓 Open Access

Pediatric systemic lupus erythematosus with lupus anticoagulant hypoprothrombinemia syndrome-A case series with review of literature

Lupus · 2021

📚 15 citations🎯 RCR 1.58

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Introduction Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has a protracted course requiring long-term immunosuppressive therapy. Due to the rarity of this syndrome and paucity of reported cases, there is lack of standardized management. We herewith report 5 children with pSLE with LAHPS. Methodology: We retrospectively reviewed clinical features, laboratory features, treatment and outcome for 5 children with lupus anticoagulant hypoprothrombinemia syndrome with SLE and a review of literature of similar cases published. Results Mean age of presentation was 10.2 ± 2.38 years (mean ± SD) and female to male ratio was 4:1. All children presented with mild to severe bleeding manifestations like gum bleed, epistaxis, hematuria, menorrhagia and subarachnoid bleed. Coagulation profile revealed prolonged PT and aPTT, with low prothrombin levels and positive Lupus anticoagulant in all children. Mixing studies were characteristic in these children. On comparing laboratory parameters majority had low C3, C4 levels, ANA and anti-DsDNA antibody positivity and three children had anticardiolipin positivity. One child had lupus nephritis along with LAHPS at presentation. All responded well to steroids and supportive measures. Conclusion High index of suspicion is needed when child with lupus presents with bleeding manifestations for early diagnosis and treatment.

Mineral Composition, Phenolic Content, and In Vitro Antidiabetic and Antioxidant Properties of Aqueous and Organic Extracts of Haloxylon scoparium Aerial Parts

Evidence-based complementary and alternative medicine : eCAM · 2021

📚 12 citations🎯 RCR 1.68🔓 Open Access📄 PDF gratuit ↗

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Haloxylon scoparium is a plant widely used in traditional medicine for the treatment of diabetes. Hence, this study focuses on the mineralogical and chemical composition and evaluation of the antidiabetic and antioxidant activities of the aerial part of this species. The mineralogical analysis was done by inductively coupled plasma atomic emission spectrometry (ICP-AES). The phytochemical study consisted in the preparation of different extracts from the aerial part by aqueous and organic extraction using Soxhlet and cold maceration. Then, phytochemical screening was performed on the plant powder and on the extracts, which is completed by spectrophotometric quantification of total polyphenols, flavonoids, and catechic tannins. The evaluation of antidiabetic activity was done by three enzymes: a-amylase, a-glucosidase, and ß-galactosidase, and that of antioxidant activity was done by five methods: H2O2, DPPH, ABTS, FRAP, and reducing power (RP). Mineralogical analysis revealed the presence of iron, potassium, magnesium, phosphorus, sodium, copper, calcium, strontium, selenium, and zinc. The studied part is rich in alkaloids, flavonoids, catechic tannins, and saponins. The methanolic extract is rich in total polyphenols (161.65 ± 1.52 Ug EAG/mg E), and the ethyl acetate extract has high levels of catechic tannins (23.69 ± 0.6 Ug EC/mg E). In addition, the decoctate expresses a high flavonoid content of 306.59 ± 4.35 Ug EQ/mg E. The in vitro evaluation of the antidiabetic activity showed that the decoctate has a higher inhibitory capacity on a-glucosidase (IC50 = 181.7 ± 21.15 ug/mL) than acarbose (IC50 = 195 ± 6.12 ug/mL). The results of the antioxidant activity showed that the methanolic extract and the decoctate present a percentage of hydrogen peroxide (H2O2) scavenging (20.91 ± 0.27 and 16.21 ± 0.39%) higher than that of ascorbic acid (14.35 ± 0.002%). Positive correlations obtained between the total polyphenol content and the antioxidant activity of the extracts were studied. A positive correlation of a-amylase inhibitory activity was also recorded with the antioxidant activity tests.

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M TOUFIK BENMOUFFOK-SAID

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Top publications · les plus citées

Publications scientifiques (32) — classées par pathologie

Transversal12

Revue générale6

Case report / série4

Épidémiologie & registres4

csDMARDs2

Lupus2

Anti-TNF1

Corticothérapie1

Gériatrie1

IA en rhumatologie1

Revue / méta-analyse1

Sclérodermie1

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