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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche
Disponibilité géographique
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78.3 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CDS MEDICO-DENTAIRE CHANZY
4 ALL FAIDHERBE, 93190 LIVRY GARGAN
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Annals of medicine and surgery (2012) · 2022
Lupus · 2021
Introduction Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has a protracted course requiring long-term immunosuppressive therapy. Due to the rarity of this syndrome and paucity of reported cases, there is lack of standardized management. We herewith report 5 children with pSLE with LAHPS. Methodology: We retrospectively reviewed clinical features, laboratory features, treatment and outcome for 5 children with lupus anticoagulant hypoprothrombinemia syndrome with SLE and a review of literature of similar cases published. Results Mean age of presentation was 10.2 ± 2.38 years (mean ± SD) and female to male ratio was 4:1. All children presented with mild to severe bleeding manifestations like gum bleed, epistaxis, hematuria, menorrhagia and subarachnoid bleed. Coagulation profile revealed prolonged PT and aPTT, with low prothrombin levels and positive Lupus anticoagulant in all children. Mixing studies were characteristic in these children. On comparing laboratory parameters majority had low C3, C4 levels, ANA and anti-DsDNA antibody positivity and three children had anticardiolipin positivity. One child had lupus nephritis along with LAHPS at presentation. All responded well to steroids and supportive measures. Conclusion High index of suspicion is needed when child with lupus presents with bleeding manifestations for early diagnosis and treatment.
Evidence-based complementary and alternative medicine : eCAM · 2021
Haloxylon scoparium is a plant widely used in traditional medicine for the treatment of diabetes. Hence, this study focuses on the mineralogical and chemical composition and evaluation of the antidiabetic and antioxidant activities of the aerial part of this species. The mineralogical analysis was done by inductively coupled plasma atomic emission spectrometry (ICP-AES). The phytochemical study consisted in the preparation of different extracts from the aerial part by aqueous and organic extraction using Soxhlet and cold maceration. Then, phytochemical screening was performed on the plant powder and on the extracts, which is completed by spectrophotometric quantification of total polyphenols, flavonoids, and catechic tannins. The evaluation of antidiabetic activity was done by three enzymes: a-amylase, a-glucosidase, and ß-galactosidase, and that of antioxidant activity was done by five methods: H2O2, DPPH, ABTS, FRAP, and reducing power (RP). Mineralogical analysis revealed the presence of iron, potassium, magnesium, phosphorus, sodium, copper, calcium, strontium, selenium, and zinc. The studied part is rich in alkaloids, flavonoids, catechic tannins, and saponins. The methanolic extract is rich in total polyphenols (161.65 ± 1.52 Ug EAG/mg E), and the ethyl acetate extract has high levels of catechic tannins (23.69 ± 0.6 Ug EC/mg E). In addition, the decoctate expresses a high flavonoid content of 306.59 ± 4.35 Ug EQ/mg E. The in vitro evaluation of the antidiabetic activity showed that the decoctate has a higher inhibitory capacity on a-glucosidase (IC50 = 181.7 ± 21.15 ug/mL) than acarbose (IC50 = 195 ± 6.12 ug/mL). The results of the antioxidant activity showed that the methanolic extract and the decoctate present a percentage of hydrogen peroxide (H2O2) scavenging (20.91 ± 0.27 and 16.21 ± 0.39%) higher than that of ascorbic acid (14.35 ± 0.002%). Positive correlations obtained between the total polyphenol content and the antioxidant activity of the extracts were studied. A positive correlation of a-amylase inhibitory activity was also recorded with the antioxidant activity tests.
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The Pan African medical journal · 2025 · Journal Article
Sagara M, Majjad A, Toufik H, Bezza A
Annals of African medicine · 2025 · Journal Article
Taoubane L, Jennane S, El Hani H, Majjad A, et al.
Annals of African medicine · 2024 · Journal Article
Toufik H, Majjad A, Ghassem MA, Djossou HJ, et al.
Postgraduate medical journal · 2023 · Journal Article
Aborode A, Awuah WA, Mehta A, Toufik AR, et al.
Annals of African medicine · 2023 · Journal Article
Errahali Y, Majjad A, Issouani J, Kasouati J, et al.
Annals of medicine and surgery (2012) · 2022 · Journal Article
Mehta A, Andrew Awuah W, Tunde Aborode A, Cheng Ng J, et al.
Postgraduate medical journal · 2022 · Journal Article
Aborode A, Awuah WA, Mehta A, Toufik AR, et al.
Case reports in rheumatology · 2022 · Case Reports
Djossou HJ, Ghassem MA, Toufik H, Oukabli M, et al.
The Pan African medical journal · 2022 · Journal Article
Missoum H, Adadi N, Alami M, Toufik H, et al.
Evidence-based complementary and alternative medicine : eCAM · 2021 · Journal Article
Lachkar N, Lamchouri F, Bouabid K, Boulfia M, et al.
Evidence-based complementary and alternative medicine : eCAM · 2021 · Journal Article
Boulfia M, Lamchouri F, Senhaji S, Lachkar N, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.
Cureus · 2025 · Case Reports
El Marbouh EK, Majjad A, Akjouj S, Boussaidane M, et al.
Cureus · 2025 · Journal Article
Das S, Kotwal V, Thakur A, T L, et al.
World journal of orthopedics · 2025 · Journal Article
Yeo PY, Kasivishvanaath A, Pérez-Carro L, T J
Physical review letters · 2025 · Journal Article
Ben Moussa A, Lamers J, Serban D, Toufik A
Cureus · 2025 · Case Reports
El Marbouh EK, Majjad A, Akjouj S, Boussaidane M, et al.
Journal of orthopaedic case reports · 2024 · Case Reports
Palasseril AS, Chegu M, Shahul MR, T GM
Journal of orthopaedic case reports · 2021 · Case Reports
G S, John JT, Nair DS, Yadav S, et al.
Case reports in rheumatology · 2021 · Case Reports
Ahmed Ghassem M, Mounach A, H Djossou J, Toufik H, et al.
Mediterranean journal of rheumatology · 2023 · Journal Article
Toufik H, Ouardi NE, Ghassem MA, Djossou JH, et al.
Rheumatology international · 2023 · Multicenter Study
Ouardi NE, Maghraoui AE, Djossou HJ, Taoubane L, et al.
Journal of hand and microsurgery · 2022 · Journal Article
T J, Stewart CJ, Tong PY, Lam WL, et al.
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
Case reports in rheumatology · 2020 · Case Reports
Machan A, Azendour H, Toufik H, Achemlal L, et al.
Cureus · 2024 · Case Reports
Nilofar F, Mohanasundaram K, Kumar M, T G
Lupus · 2021 · Case Reports
Kocheril AP, Vettiyil GI, George AS, Shah S, et al.
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
Cureus · 2025 · Journal Article
Sagara M, Majjad A, Toufik H, Ahmed B
Cureus · 2025 · Journal Article
Das S, Kotwal V, Thakur A, T L, et al.
Postgraduate medical journal · 2023 · Journal Article
Awuah WA, Kalmanovich J, Mehta A, Huang H, et al.
Journal of Taibah University Medical Sciences · 2024 · Journal Article
Adel K, Fayçal A, Toufik B, Abdelhalim M
Access microbiology · 2025 · Case Reports
Zouaki H, Laatiris H, Taoubane L, Mejjad A, et al.
Journal of Taibah University Medical Sciences · 2024 · Journal Article
Adel K, Fayçal A, Toufik B, Abdelhalim M
Middle East African journal of ophthalmology · 2023 · Journal Article
Toufik H, Ghassem MA, Majjad A, Mounach A, et al.
Bone · 2020 · Journal Article
Majjad A, Ghassem MA, Toufik H, Sadni S, et al.