📇 Rhumatologue · PARIS CEDEX 14 · (75) · Salarié

M JEAN-MICHEL BENICHOU

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15 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS CEDEX 14 (75)SalariéRPPS 10000147842

✨ Génération du profil synthétique IA en cours…

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INSTITUT MEDICO-CHIRURGICAL MONTSOURIS
42 BD JOURDAN, 75674 PARIS CEDEX 14
☎ 0156616029Activité de soin et de pharmacie

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Top publications · les plus citées

Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects

Journal of internal medicine · 2014

📚 109 citations🎯 RCR 4.31Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractObjectivesThe aim of this study was to investigate whether the quadrivalent human papillomavirus (HPV) vaccine Gardasil is associated with a change in the risk of autoimmune disorders (ADs) in young female subjects.DesignSystematic case–control study of incident ADs associated with quadrivalent HPV vaccination in young women across France.Participants and settingA total of 113 specialised centres recruited (from December 2007 to April 2011) females aged 14–26 years with incident cases of six types of ADs: idiopathic thrombocytopenic purpura (ITP), central demyelination/multiple sclerosis (MS), Guillain–Barré syndrome, connective tissue disorders (systemic lupus erythematosus, rheumatoid arthritis/juvenile arthritis), type 1 diabetes mellitus and autoimmune thyroiditis. Control subjects matched to cases were recruited from general practice.AnalysisMultivariate conditional logistic regression analysis; factors included age, geographical origin, smoking, alcohol consumption, use of oral contraceptive(s) or vaccine(s) other than Gardasil received within 24 months before the index date and personal/family history of ADs.ResultsOverall, 211 definite cases of ADs were matched to 875 controls. The adjusted odds ratio (OR) for any quadrivalent HPV vaccine use was 0.9 [95% confidence interval (CI) 0.5–1.5]. The individual ORs were 1.0 (95% CI 0.4–2.6) for ITP, 0.3 (95% CI 0.1–0.9) for MS, 0.8 (95% CI 0.3–2.4) for connective disorders and 1.2 (95% CI 0.4–3.6) for type 1 diabetes. No exposure to HPV vaccine was observed in cases with either Guillain–Barré syndrome or thyroiditis.ConclusionsNo evidence of an increase in the risk of the studied ADs was observable following vaccination with Gardasil within the time periods studied. There was insufficient statistical power to allow conclusions to be drawn regarding individual ADs.

Gastrointestinal tract involvement in polyarteritis nodosa and Churg-Strauss syndrome

Annales de medecine interne · 1995

📚 50 citations🎯 RCR 2.45Top 21% NIH

Channelling of COX-2 inhibitors to patients at higher gastrointestinal risk but not at lower cardiovascular risk: the Cox2 inhibitors and tNSAIDs description of users (CADEUS) study

Pharmacoepidemiology and drug safety · 2007

📚 29 citations

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AbstractPurposeTo describe the characteristics of users of cyclo‐oxygenase (COX)‐2 inhibitors and traditional nonselective non‐steroidal anti‐inflammatory drugs (tNSAIDs) in France.MethodsBetween 1 August 2003 and 31 July 2004, patients who received at least one dispensing of celecoxib, rofecoxib or tNSAIDs were randomly sampled with a 1:1:2 target ratio within the French National Healthcare Insurance database. Patients and prescribers were asked to fill a questionnaire on socio‐demographic characteristics, NSAID indication and use and previous medical history. For each respondent, healthcare resources used in the 6 months before inclusion were extracted from the database. Multivariate logistic regression was used to study the determinants of a first COX‐2 inhibitor dispensing.ResultsOf the 45 217 patients included, 13 065 COX‐2 inhibitors and 13 553 tNSAID users had prescriber data. Ninety seven per cent of COX‐2 inhibitor prescriptions were for ‘rheumatological’ indications, whereas 37% of tNSAIDs use was for benign diseases (n = 2643) or analgesia (n = 2318). Among patients with rheumatological indications (n = 4730) and a first COX‐2 inhibitor (n = 2427) or tNSAID (n = 2303) dispensing, multivariate analysis of factors associated with COX‐2 inhibitors dispensing showed that, compared to new tNSAID users, new COX‐2 inhibitor users were older, more often female, on sick leave or unemployed. COX‐2 use was also associated with previous gastrointestinal history and previous gastroprotective agent dispensing, but not with previous cardiovascular (CV) history.ConclusionThe choice of NSAID depended largely on indication and on previous gastrointestinal history, in line with the recommendations of the French health authorities. Possible knowledge of CV risk associated with COX‐2 inhibitors did not influence prescribing. Copyright © 2007 John Wiley & Sons, Ltd.

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M JEAN-MICHEL BENICHOU

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Top publications · les plus citées

Publications scientifiques (15) — classées par pathologie

Transversal6

Pharmacovigilance2

Activité physique / Rééducation1

Anti-TNF1

Arthrite juvénile1

Biothérapies non-anti-TNF1

csDMARDs1

Gériatrie1

Lupus1

Risque cardio-vasculaire1

Vascularites1

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