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M MICHEL BECKERS

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Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10001298388

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects

American journal of human genetics · 2011

📚 93 citations🎯 RCR 2.72Top 18% NIH🔓 Open Access📄 PDF gratuit ↗

Two-dimensional global longitudinal strain rate is a preload independent index of systemic right ventricular contractility in hypoplastic left heart syndrome patients after Fontan operation

Circulation. Cardiovascular imaging · 2014

📚 58 citations🎯 RCR 2.54Top 20% NIH🔓 Open Access📄 PDF gratuit ↗

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Background— Assessment of systemic right ventricular (RV) function in patients with hypoplastic left heart syndrome is important during long-term follow-up after Fontan repair. Traditional echocardiographic parameters to evaluate systolic ventricular function are affected by loading conditions. The only generally accepted load-independent parameter of systolic function, end systolic elastance ( E es ), requires invasive catheterization. Therefore, we sought to determine if parameters obtained by 2-dimensional speckle tracking (2DST) were affected by acute changes in preload and correlated with catheterization-derived indices of RV contractility in hypoplastic left heart syndrome patients after Fontan palliation. Methods and Results— Fifty-two patients with hypoplastic left heart syndrome (median age, 6.6; range 2.9–22.2 years) were prospectively enrolled to have echocardiography and conductance catheter studies performed simultaneously. We compared traditional echo, 2-dimensional speckle tracking and catheterization-derived parameters during different states of preload at baseline and during dobutamine infusion. Global longitudinal strain (S) showed a tendency to decrease with preload reduction, whereas global longitudinal strain rate (SR) did not change (S: −17.7±3.4% versus −16.9±3.8%, P =0.08; SR: −1.30±0.29 versus −1.34±0.34 s −1 , P =0.3). S did not change with dobutamine infusion (−17.7±3.4% versus −18.4±3.9%, P =0.24), whereas SR increased significantly (−1.30±0.29 versus −2.26±0.49 s −1 , P <0.001). RV E es correlated with SR ( r s = −0.47, P <0.001), but not with S ( r s =0.07, P =0.5) or other echocardiographic parameters. Conclusions— In contrast to S, SR was not affected by preload and correlated with E es of the systemic RV. SR may be a useful noninvasive surrogate of RV contractility and suitable for follow-up of patients with hypoplastic left heart syndrome after Fontan palliation.

Genome-wide association study of body mass index in 23 000 individuals with and without asthma

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013

📚 57 citations🎯 RCR 1.76🔓 Open Access

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Summary Background Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co‐morbidity between these conditions. Objective To identify genetic variants that are associated with body mass index ( BMI ) in asthmatic children and adults, and to evaluate if there are differences between the genetics of BMI in asthmatics and healthy individuals. Methods In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. In total, 19 studies contributed with genome‐wide analysis study ( GWAS ) data from more than 23 000 individuals with predominantly European descent, of whom 8165 are asthmatics. Results We report associations between several DENND 1B variants ( P = 2.2 × 10 −7 for rs4915551) on chromosome 1q31 and BMI from a meta‐analysis of GWAS data using 2691 asthmatic children (screening data). The top DENND 1B single nucleotide polymorphisms ( SNP s) were next evaluated in seven independent replication data sets comprising 2014 asthmatics, and rs4915551 was nominally replicated ( P < 0.05) in two of the seven studies and of borderline significance in one ( P = 0.059). However, strong evidence of effect heterogeneity was observed and overall, the association between rs4915551 and BMI was not significant in the total replication data set, P = 0.71. Using a random effects model, BMI was overall estimated to increase by 0.30 kg/m 2 ( P = 0.01 for combined screening and replication data sets, N = 4705) per additional G allele of this DENND 1B SNP . FTO was confirmed as an important gene for adult and childhood BMI regardless of asthma status. Conclusions and Clinical Relevance DENND 1B was recently identified as an asthma susceptibility gene in a GWAS on children, and here, we find evidence that DENND 1B variants may also be associated with BMI in asthmatic children. However, the association was overall not replicated in the independent data sets and the heterogeneous effect of DENND 1B points to complex associations with the studied diseases that deserve further study.

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M MICHEL BECKERS

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Top publications · les plus citées

Publications scientifiques (25) — classées par pathologie

Transversal12

Génétique3

Vascularites3

Épidémiologie & registres2

Case report / série1

Essai clinique1

Fièvres auto-inflammatoires1

Revue générale1

Santé mentale / fatigue1

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