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MME Michele BALAUGE

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1 raison identifiée

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10002052487

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

TAPSE/sPAP Ratio to Improve Risk Assessment in Pulmonary Arterial Hypertension

Circulation. Heart failure · 2025

📚 8 citations🎯 RCR 3.58

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BACKGROUND: Right ventricular functional adaptation to afterload is a major determinant of outcome in pulmonary arterial hypertension (PAH). We aimed to investigate if right ventricular-pulmonary artery (PA) coupling evaluated by the ratio of tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (sPAP) improves risk assessment scores for survival prediction. METHODS: A total of 677 consecutive patients with PAH (55% idiopathic) were prospectively enrolled with follow-up clinical, right heart catheterization, and echocardiographic evaluations within 12 months (interquartile range, 180–344 days) after initiation of targeted therapies in 11 Italian centers. European Society of Cardiology/European Respiratory Society guidelines-derived risk scores and REVEAL 2.0 (US Registry to Evaluate Early and Long-Term PAH Disease Management 2.0) risk scores were collected at baseline and follow-up. 254 consecutive patients with PAH retrospectively enrolled in a German reference center served as a validation cohort. RESULTS: A low-risk status at a median of 3.7 years (interquartile range, 1.2–6.8) follow-up was significantly associated with each unit (0.1 mm/mm Hg) increase in TAPSE/sPAP under targeted therapies (European Society of Cardiology/European Respiratory Society score: odds ratio, 1.78; P ≤0.001; REVEAL 2.0 score: odds ratio, 1.43; P ≤0.001). At follow-up, the TAPSE/sPAP ratio increased the prognostic information of each risk stratum of the European Society of Cardiology/European Respiratory Society risk score, except the highest risk stratum, with 0.5 mm/mm Hg, 0.35 mm/mm Hg, and 0.30 mm/mm Hg, from the lowest to the intermediate-high risk score, identified as the best cutoff value. TAPSE/sPAP ratio increased the prognostic information of the REVEAL 2.0 score at follow-up, with 0.35 mm/mm Hg identified as the best cutoff value to discriminate within a score of 5 to 8, with no added value for scores <5 and >8. These results were confirmed in the validation cohort. CONCLUSIONS: Assessment of right ventricular-PA coupling by the TAPSE/sPAP ratio in PAH improves risk assessment scores except in the lowest or most advanced stage of the disease

Effectiveness of tezepelumab in severe asthma: A multicenter real-world study

European journal of internal medicine · 2026

📚 5 citations🎯 RCR 5.00🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Internal Phase Separation in Synthetic DNA Condensates

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025

📚 5 citations🎯 RCR 1.87🔓 Open Access📄 PDF gratuit ↗

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Abstract Biomolecular condensates regulate cellular biochemistry by organizing enzymes, substrates and metabolites, and often acquire partially de‐mixed states whereby distinct internal domains play functional roles. Despite their physiological relevance, questions remain about the principles underpinning the emergence of multi‐phase condensates. Here, a model system of synthetic DNA nanostructures able to form monophasic or biphasic condensates is presented. Key condensate features, including the degree of interphase mixing and the relative size and spatial arrangement of domains, can be controlled by altering nanostructure stoichiometries. The modular nature of the system facilitates an intuitive understanding of phase behavior, and enables mapping of the experimental phenomenology onto a predictive Flory‐Huggins model. The experimental and theoretical framework introduced is expected to help address open questions on multiphase condensation in biology and aid the design of functional biomolecular condensates in vitro, in synthetic cells, and in living cells.

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MME Michele BALAUGE

Pourquoi vous devez consulter ce praticien

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Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal26

Épidémiologie & registres6

Revue générale6

Revue / méta-analyse4

Case report / série3

Recommandations3

Vraie vie / RWE2

Essai clinique1

IRM ostéo-articulaire1

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

Santé mentale / fatigue1

SAPL1

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