📇 Rhumatologue · PARIS CEDEX 13 · (75) · Hospitalier

MME ISABELLE ARNULF

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5 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
42 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Conseils vidéo gratuits
12 vidéos pédagogiques pour préparer ou prolonger la consultation
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS CEDEX 13 (75)HospitalierRPPS 10001034528

Enseignement

📊 Reconnaissance scientifique : 90/100📝 762 articles publiés🇫🇷 Publications académiques françaises (8)🎓 6 thèses dirigées

✨ Génération du profil synthétique IA en cours…

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease

Molecular neurodegeneration · 2025

📚 20 citations🎯 RCR 8.89🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Parkinson disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy are synucleinopathies, characterized by neuronal loss, gliosis and the abnormal deposition of α-synuclein in vulnerable areas of the nervous system. Neurodegeneration begins however several years before clinical onset of motor, cognitive or autonomic symptoms. The isolated form of REM sleep behavior disorder (RBD), a parasomnia with dream enactment behaviors and excessive muscle activity during REM sleep, is an early stage synucleinopathy. The neurophysiological hallmark of RBD is REM sleep without atonia (RWSA), i.e. the loss of physiological muscle atonia during REM sleep. RBD pathophysiology is not fully clarified yet, but clinical and basic science suggest that ɑ-syn pathology begins in the lower brainstem where REM atonia circuits are located, including the sublaterodorsal tegmental/subcoeruleus nucleus and the ventral medulla, then propagates rostrally to brain regions such as the substantia nigra, limbic system, cortex. Genetically, there is only a partial overlap between RBD, PD and DLB, and individuals with iRBD may represent a specific subpopulation. A genome-wide association study identified five loci, which all seem to revolve around the GBA1 pathway. iRBD patients often show subtle motor, cognitive, autonomic and/or sensory signs, neuroimaging alterations as well as biofluid and tissue markers of neurodegeneration (in particular pathologic α-synuclein aggregates), which can be useful for risk stratification. Patients with iRBD represent thus the ideal population for neuroprotective/neuromodulating trials. This review provides insights into these aspects, highlighting and substantiating the central role of iRBD in treatment development strategies for synucleinopathies.

Conscious experiences during non-rapid eye movement sleep parasomnias

Neuroscience and biobehavioral reviews · 2024

📚 8 citations🎯 RCR 2.89Top 17% NIH🔓 Open Access

Early brain iron changes in Parkinson's disease and isolated rapid eye movement sleep behaviour disorder: a four-year longitudinal multimodal quantitative MRI study

Brain communications · 2025

📚 7 citations🎯 RCR 3.00🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Parkinson's disease demonstrates increased iron concentration in the substantia nigra (SN). The progression of iron and its interaction with neuromelanin content and dopaminergic dysregulation from prodromal to early-stage Parkinson's disease remain poorly understood. Using quantitative susceptibility mapping (QSM) and R2* relaxation rate, we investigated brain iron changes in patients with isolated rapid eye movement (REM) sleep behaviour disorder and early-stage Parkinson's disease. Subjects were scanned longitudinally at 3.0 Tesla MRI. QSM and R2* values were calculated in the entire SN and its anterior and posterior dorsal and ventral subdivisions. Baseline and longitudinal group differences were tested using analysis of variance of multiple linear regression models controlling for age and sex and linear mixed-effects modelling respectively. We included 44/36/28 healthy volunteers (HVs), 49/20/11 isolated REM sleep behaviour disorder, 127/88/50 Parkinson's disease at first/second/third visit respectively, separated by a 2-year interval. At baseline, there was a significant increase in QSM and R2* values in Parkinson's disease versus HVs in the posteroventral SN only (QSM: +17.6%%; R2*: +7.1%), which did not reach significance in isolated REM sleep behaviour disorder (QSM: +6.9%, R2*: +3.3%). Longitudinally, only posteroventral SN values demonstrated significant effects for Group and Visit using QSM and R2*. Further, the Group-by-Visit interaction was significant only for QSM. The posteroventral SN iron increased with disease duration and was inversely correlated with the changes in nigral neuromelanin content and striatal DaT levels in Parkinson's disease. The posteroventral nigral iron increased with the progression of the disease as well as dopaminergic denervation in Parkinson's disease. QSM was a stronger quantitative longitudinal marker than R2* in detecting regional nigral iron abnormalities as the disease progressed.

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MME ISABELLE ARNULF

Pourquoi vous devez consulter ce praticien

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Publications académiques en France

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Vidéos & interventions (12)

Comment Isabelle Arnulf va changer le monde

Film de présentation des travaux de Isabelle Arnulf et Mehdi Tafti

[Isabelle Arnulf] La science des rêves

"Certaines personnes peuvent changer le scénario de leurs rêves"

De quoi rêvent les aveugles ?

Les rêves, une fenêtre pour la recherche sur le cerveau

Dr. Isabelle Arnulf: Women and IH

Stéphanie Bioulac - Sommeil de l'enfant et TDAH - Congrès du Sommeil 2023

Les rêves, une fenêtre pour la recherche sur le cerveau - ISABELLE ARNULF

Top publications · les plus citées

Publications scientifiques (42) — classées par pathologie

Santé mentale / fatigue34

Transversal8

Économie santé2

Génétique2

Recommandations1

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