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Praticien-chercheur
9 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
126.7 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
POLYCLINIQUE VAUBAN
10 AV VAUBAN, 59300 VALENCIENNES
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Critical care (London, England) · 2010
Abstract Introduction Hyponatremia in the intensive care unit (ICU) is most commonly related to inappropriate secretion of antidiuretic hormone (SIADH). Fluid restriction is difficult to apply in these patients. We wanted to report the treatment of hyponatremia with urea in these patients. Methods Two groups of patients are reported. The first one is represented by a retrospective study of 50 consecutive patients with mild hyponatremia treated with urea. The second group is presented by a series of 35 consecutive patients with severe hyponatremia acquired outside the hospital (≤ 115 mEq/L) who where treated by isotonic saline and urea (0.5 to 1 g/kg/day), administered usually by gastric tube. Results In the first group with mild hyponatremia (128 ± 4 mEq/L) the serum sodium (SNa) increased to a mean value of 135 ± 4 mEq/L (P < 0.001) after two days of urea therapy (46 ± 25 g/day), despite a large fluid intake (> 2 L/day). The mean duration of urea therapy was six days (from 2 to 42 days). Six patients developed hyponatremia again once the urea was stopped, which necessitated its reintroduction. Six patients developed hypernatremia (maximum value 155 mEq/L). In the second group, SNa increased from 111 ± 3 mEq/L to 122 ± 4 mEq/L in one day (P < 0.001). All the patients with neurological symptoms made a rapid recovery. No side effects were observed. Conclusions These data show that urea is a simple and inexpensive therapy to treat euvolemic hyponatremia in the ICU.
The British journal of dermatology · 2010
Journal of sleep research · 2014
SummaryEvidence suggests that autoimmune diseases tend to co‐occur so that patients with an autoimmune disorder are at higher risk of a second autoimmune disease. The association between allergic and autoimmune diseases is also of considerable interest. There are no reports on the association between sporadic or familial narcolepsy with cataplexy and other non‐neurological immune‐mediated diseases. This study reported on the comorbid immunopathological diseases associated with narcolepsy. One‐hundred and fifty six narcoleptic patients with a mean age at diagnosis of 39.1 ± 17.8 years (range, 6–70 years) were assessed using the clinical history, physical and neurological examinations, sleep questionnaires, neuroimaging and human leucocyte antigen typing. Diagnosis was confirmed by polysomnography followed by a multiple sleep latency test or by measuring hypocretin‐1 levels. Patients with immunopathological diseases were matched for gender and age at the onset of narcoleptic symptoms with narcoleptic patients without immunopathological diseases. Twenty‐six patients (16.6%; 50% women; one familial, 25 sporadic) had one or more immunopathological diseases associated: autoimmune diseases, such as idiopathic thrombocytopenic purpura, multiple sclerosis, systemic lupus erythematosus, psoriasis, Crohn's disease, ulcerative colitis, autoimmune thyroid disease, Peyronie's disease and idiopathic recurrent facial palsy; other immunopathological diseases, like atopic dermatitis, allergic asthma and allergic rhinitis. Although not significant, the age at diagnosis of narcolepsy was 9.3 years earlier in patients with narcolepsy + immunopathological diseases. The results demonstrate that the prevalence of comorbid immunopathological diseases is high in narcolepsy, and cataplexy is significantly more severe in patients with narcolepsy + immunopathological diseases.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
BMC research notes · 2014 · Case Reports
Kurz C, Wunderlich S, Spieler D, Schwaiger BJ, et al.
Anales del sistema sanitario de Navarra · 2013 · Case Reports
Ulibarrena N, Andrés C, Bernaola E, Herranz M, et al.
Journal of dermatological case reports · 2012 · Case Reports
Alhathlool A, Hein R, Andres C, Ring J, et al.
Der Pathologe · 2014 · Case Reports
Franz R, Andres C
Critical care (London, England) · 2010 · Comparative Study
Decaux G, Andres C, Gankam Kengne F, Soupart A
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007 · Case Reports
Belloni B, Andres C, Ott G, Hein R, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2016 · Case Reports
Garzorz N, Papanagiotou V, Atenhan A, Andres C, et al.
Journal of dermatological case reports · 2012 · Case Reports
Alhathlool A, Hein R, Andres C, Ring J, et al.
Journal of sleep research · 2014 · Journal Article
Martínez-Orozco FJ, Vicario JL, Villalibre-Valderrey I, De Andrés C, et al.
The British journal of dermatology · 2010 · Journal Article
Andres C, Kollmar A, Mempel M, Hein R, et al.