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Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
77.4 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
EHPAD LE MONTHEARD
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European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020
Lupus · 2008
Mycophenolate mofetil (MMF) with prednisolone has been associated with high remission rates when used as induction treatment for lupus nephritis. This prospective, multicentre, cohort study investigates the efficacy and safety of this regimen over 24 weeks in 213 Chinese patients with active lupus nephritis (Classes III, IV, V or combination). Baseline activity index (AI) was 6.91 ± 3.33 and chronicity index (CI) was 1.9 ± 1.2. The remission rate was 82.6% at 24 weeks (complete remission, 34.3%; partial remission, 48.4%). There were significant ( P < 0.01) improvements in kidney function shown by reductions in proteinuria, serum albumin, serum creatinine and creatinine clearance, as well as in systemic lupus erythematosus disease activity index (SLEDAI) scores. Independent risk factors influencing remission were pathological classification (including Class V and III or Class V and IV nephritis) and elevated serum creatinine at baseline (OR 2.967, 95% CI: 1.479–6.332, P = 0.001 and OR 1.007, 95% CI: 1.002–1.011, P = 0.001, respectively). Patients with concomitant membranous features on biopsy had a lower remission rate than those with Class III and IV nephritis (66.7% vs 87.3%, P = 0.002). Renal biopsy was repeated in 25 patients following treatment. There was a transition to less severe pathological morphologies in majority of subjects. Infections were monitored throughout treatment: eight patients (3.8%) experienced bacterial infections, whereas herpes zoster occurred in seven patients. Nine patients (4.2%) suffered from gastrointestinal upset, which resolved without discontinuation of MMF. One patient became leucopenic, whereas another died from active disease unrelated to kidney symptoms. MMF combined with prednisolone is an effective and well-tolerated induction treatment for patients with active lupus nephritis and for controlling SLE systemic activity.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The Journal of the Association of Physicians of India · 2022 · Journal Article
Nair A, Pruthi P, L S, Marwaha V, et al.
PloS one · 2020 · Journal Article
Desai G, T S J, G SK, L M, et al.
Theranostics · 2020 · Comparative Study
Coussy F, Lavigne M, de Koning L, Botty RE, et al.
Experimental and therapeutic medicine · 2013 · Journal Article
Wong JY, Chen YS, Chakravarthi S, Judson JP, et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020 · Journal Article
Armangue T, Capobianco M, de Chalus A, Laetitia G, et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020 · Journal Article
Bruijstens AL, Wendel EM, Lechner C, Bartels F, et al.
International medical case reports journal · 2025 · Case Reports
Posite Charles M, Faustin TM, Woldemichael MA, Vargas Escalante E, et al.
Cureus · 2025 · Case Reports
Ghosh S, Vittobarao PG, S S, L A, et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020 · Journal Article
Armangue T, Capobianco M, de Chalus A, Laetitia G, et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020 · Journal Article
Bruijstens AL, Wendel EM, Lechner C, Bartels F, et al.
Lupus · 2008 · Clinical Trial
F L, Y T, X P, L W, et al.
European journal of medical genetics · 2022 · Journal Article
Laetitia MM, Veronique K, Mamy NZ, Cathy SM, et al.
Zhongguo gu shang = China journal of orthopaedics and traumatology · 2023 · Meta-Analysis
Zhou GB, Lyu Y, L J, Lin ZH, et al.
Oral oncology reports · 2023 · Journal Article
Aboubacar BH, Jumelle ZNA, Odero-Marah V, Romuald KT, et al.
Hemodialysis international. International Symposium on Home Hemodialysis · 2014 · Journal Article
Fischbach M, Zaloszyc A, Laetitia H, Menouer S, et al.