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MME Carole ALEXANDRE

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue

Rhumatologue

RPPS 10002074523

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts

Lancet (London, England) · 2000

📚 494 citations🎯 RCR 13.85Top 1% NIH

High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008

📚 153 citations🎯 RCR 5.31Top 7% NIH

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Abstract We depict a fragility bone state in two primitive osteoporosis populations using 3D high-resolution peripheral in vivo QCT (HR-pQCT). Postmenopausal women (C, controls, n = 54; WF, wrist, n = 50; HF, hip, n = 62 recent fractured patients) were analyzed for lumbar and hip DXA areal BMD (aBMD), cancellous and cortical volumetric BMD (vBMD), and microstructural and geometric parameters on tibia and radius by HR-pQCT. Principal component analysis (PCA) allowed extracting factors that best represent bone variables. Comparison between groups was made by analysis of covariance (ANCOVA). Two factors (&gt;80% of the entire variability) are extracted by PCA: at the radius, the first is a combination of trabecular parameters and the second of cortical parameters. At the tibia, we found the reverse. Femoral neck aBMD is decreased in WF (8.6%) and in HF (18%) groups (no lumbar difference). WF showed a ∼20% reduction in radius trabecular vBMD and number. Radius cortical vBMD and thickness decrease by 6% and 14%, respectively. At the tibia, only the cortical compartment is affected, with ∼20% reduction in bone area, thickness, and section modulus and 6% reduction in vBMD. HF showed same radius trabecular alterations than WF, but radius cortical parameters are more severely affected than WF with reduced bone area (25%), thickness (28.5%), and vBMD (11%). At the tibia, trabecular vBMD and number decrease by 26% and 17.5%, respectively. Tibia cortical bone area, thickness, and section modulus showed a &gt;30% decrease, whereas vBMD reduction reached 13%. Geometry parameters at the tibia displayed the greatest differences between healthy and fractured patients and between wrist and hip fractures.

3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis

Medical & biological engineering & computing · 2000

📚 153 citations🎯 RCR 5.33Top 7% NIH🔓 Open Access

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MME Carole ALEXANDRE

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Articles de presse (1)

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal39

Anti-TNF5

csDMARDs1

IRM ostéo-articulaire1

Maladie de Horton1

Ostéomalacie1

Ostéoporose1

Qualité de vie / PROMs1

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