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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
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Cytokine · 2007
Frontiers in endocrinology · 2024
Osteoarthritis (OA) is an intricate pathological condition that primarily affects the entire synovial joint, especially the hip, hand, and knee joints. This results in inflammation in the synovium and osteochondral injuries, ultimately causing functional limitations and joint dysfunction. The key mechanism responsible for maintaining articular cartilage function is chondrocyte metabolism, which involves energy generation through glycolysis, oxidative phosphorylation, and other metabolic pathways. Some studies have shown that chondrocytes in OA exhibit increased glycolytic activity, leading to elevated lactate production and decreased cartilage matrix synthesis. In OA cartilage, chondrocytes display alterations in mitochondrial activity, such as decreased ATP generation and increased oxidative stress, which can contribute to cartilage deterioration. Chondrocyte metabolism also involves anabolic processes for extracellular matrix substrate production and energy generation. During OA, chondrocytes undergo considerable metabolic changes in different aspects, leading to articular cartilage homeostasis deterioration. Numerous studies have been carried out to provide tangible therapies for OA by using various models in vivo and in vitro targeting chondrocyte metabolism, although there are still certain limitations. With growing evidence indicating the essential role of chondrocyte metabolism in disease etiology, this literature review explores the metabolic characteristics and changes of chondrocytes in the presence of OA, both in vivo and in vitro. To provide insight into the complex metabolic reprogramming crucial in chondrocytes during OA progression, we investigate the dynamic interaction between metabolic pathways, such as glycolysis, lipid metabolism, and mitochondrial function. In addition, this review highlights prospective future research directions for novel approaches to diagnosis and treatment. Adopting a multifaceted strategy, our review aims to offer a comprehensive understanding of the metabolic intricacies within chondrocytes in OA, with the ultimate goal of identifying therapeutic targets capable of modulating chondrocyte metabolism for the treatment of OA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Computational biology and chemistry · 2026 · Journal Article
Ahmed EA, Rajendran P, Adam MSS, Abdelsalam S
PloS one · 2025 · Journal Article
Zhang Y, Ren X, Zhuang H, Li H, et al.
Frontiers in endocrinology · 2024 · Journal Article
Adam MS, Zhuang H, Ren X, Zhang Y, et al.
Journal of orthopaedic case reports · 2024 · Case Reports
Alhadi AAA, Mohamed AABD, Abdalla EMH, Adam MYA, et al.
Journal of orthopaedic surgery and research · 2023 · Clinical Trial
Abdelnasser MK, Abdelhameed MA, Bassem M, Adam MF, et al.
Journal of orthopaedic surgery and research · 2021 · Journal Article
Abdelnasser MK, Khalifa AA, Bassem M, Abdelhameed MA, et al.
Retinal cases & brief reports · 2017 · Case Reports
Ehmann DS, Adam MK, Kasi SK, Sivalingam A, et al.
Zeitschrift fur Rheumatologie · 2015 · Journal Article
Ucar M, Sarp U, Kirboga K, Adam M, et al.
International journal of nanomedicine · 2011 · Journal Article
Xu W, Ganz C, Weber U, Adam M, et al.
Rheumatology international · 2010 · Journal Article
Al-Mogairen SM, Meo SA, Al-Arfaj AS, Hamdani M, et al.
Rheumatology international · 2008 · Journal Article
Adam M, Erkan AN, Arslan D, Leblebici B, et al.
Cytokine · 2007 · Journal Article
Hulejová H, Baresová V, Klézl Z, Polanská M, et al.
Rheumatology international · 2006 · Comparative Study
Spacek P, Adam M
Journal of bone and mineral metabolism · 2003 · Journal Article
Gur A, Nas K, Kayhan O, Atay MB, et al.
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2003 · English Abstract
Adam M, Petrtýl M, Balík K, Bastl Z
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2003 · Journal Article
Hulejová H, Spacek P, Klézl Z, Trc T, et al.
Casopis lekaru ceskych · 2002 · English Abstract
St'ovícková J, Hulejová H, Pesáková V, Spacek P, et al.
General physiology and biophysics · 1999 · Journal Article
Martínek J, Hulejová H, Adam M
Casopis lekaru ceskych · 1996 · Clinical Trial
Adam M, Spacek P, Hulejová H, Galiánová A, et al.
Vnitrni lekarstvi · 1996 · English Abstract
Blahos J, Adam M, Hulejová H, Spacek P
Annales de medecine interne · 1996 · Journal Article
Amiral J, Adam M, Cluzeau D, Vissac AM, et al.
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 1992 · English Abstract
Becvár R, Lichý A, Macek J, Adam M
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 1992 · English Abstract
Becvár R, Novotná J, Krbec M, Cech O, et al.
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 1991 · English Abstract
Becvár R, Myllylä R, Krbec M, Cech O, et al.
Journal of chromatography · 1991 · Journal Article
Lichý A, Macek J, Adam M
Zeitschrift fur Rheumatologie · 1991 · Journal Article
Novotná J, Hulejová H, Svoboda T, Deyl Z, et al.
Zeitschrift fur Rheumatologie · 1991 · Journal Article
Novotná J, Miterová L, Krabcová M, Deyl Z, et al.
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 1989 · English Abstract
Adam M, Hulejová H, Miterová S
Clinica chimica acta; international journal of clinical chemistry · 1989 · Journal Article
Myllylä R, Becvar R, Adam M, Kivirikko KI
Casopis lekaru ceskych · 1989 · English Abstract
Novotná J, Hulejová H, Svoboda T, Trc T, et al.
Casopis lekaru ceskych · 1989 · English Abstract
Novotná J, Krabcová M, Deyl Z, Adam M
Clinical rheumatology · 1988 · Journal Article
Svobodová J, Becvár R, Novotná J, Havelka S, et al.
Zeitschrift fur Rheumatologie · 1987 · Journal Article
Macek J, Adam M
Vnitrni lekarstvi · 1987 · English Abstract
Krajícková J, Macek J, Medová N, Adam M
Scandinavian journal of rheumatology · 1986 · Comparative Study
Tellerová K, Spacek P, Adam M
Casopis lekaru ceskych · 1984 · English Abstract
Adam M, Trnavský K
Acta biologica Hungarica · 1984 · Journal Article
Adam M, Novotná J, Deyl Z
Fysiatricky a reumatologicky vestnik · 1983 · English Abstract
Miterová L, Bozdĕch V, Adam M
Journal of chromatography · 1983 · Journal Article
Tellerovå K, Spacek P, Adam M
Casopis lekaru ceskych · 1980 · English Abstract
Adam M, Krabcová M, Miterová L, von der Mark K, et al.
Pharmacology · 1980 · Journal Article
Adam M, Musilova J, Krabcova M, Brettschneider I, et al.
Arzneimittel-Forschung · 1980 · Journal Article
Adam M, Krabcová M, Musilová J, Pesáková V, et al.
European journal of radiology open · 2022 · Journal Article
Adam M, Ibrahim B, Khidir R, Elmahdi E, et al.
Statistics in medicine · 2016 · Journal Article
Dimou NL, Adam M, Bagos PG
International journal of biological macromolecules · 2024 · Journal Article
Mohammed OA, Alghamdi M, Adam MIE, BinAfif WF, et al.
European journal of radiology open · 2022 · Journal Article
Adam M, Ibrahim B, Khidir R, Elmahdi E, et al.
PloS one · 2019 · Journal Article
Chambers CD, Johnson DL, Xu R, Luo Y, et al.
Acta ophthalmologica · 2014 · Journal Article
Graves GS, Adam MK, Stepien KE, Han DP
Ceskoslovenska pediatrie · 1989 · English Abstract
Svobodová J, Becvár R, Novotná J, Havelka S, et al.
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022 · Journal Article
Adam M, Alkaramany E, Alhamoud A, Derbas J, et al.
European journal of radiology open · 2022 · Journal Article
Adam M, Ibrahim B, Khidir R, Elmahdi E, et al.
Journal of shoulder and elbow surgery · 2024 · Journal Article
Adam MF, Lädermann A, Denard PJ, Lacerda F, et al.