Docteur MARINE MEUNIER

Thèses universitaires

• Recherche et caractérisation d'antigènes vaccinaux contre Campylobacter par vaccinologie inverse

  2017

  Research and characterization of vaccine antigens against Campylobacter by reverse vaccinology

  Biologie🎓 Rennes 1

  Direction : Marianne Chemaly, Daniel Dory

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Body mass index influences the response to infliximab in ankylosing spondylitis.

  2012

  ArticleArthritis Research and Therapy

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

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Lieux de consultation

• CHI ROBERT BALLANGER

  Boulevard ROBERT BALLANGER, 93420 Villepinte

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Tarifs & secteur de conventionnement

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Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study

  Annals of the rheumatic diseases · 2013

  📚 131 citations🎯 RCR 4.80Top 8% NIH
• 2

  Bone mineral density evolution after successful parathyroidectomy in patients with normocalcemic primary hyperparathyroidism

  The Journal of clinical endocrinology and metabolism · 2013

  📚 93 citations🎯 RCR 4.07Top 11% NIH🔓 Open Access📄 PDF gratuit ↗
• 3

  Body mass index influences the response to infliximab in ankylosing spondylitis

  Arthritis research & therapy · 2012

  📚 84 citations🎯 RCR 2.94Top 17% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Introduction The excess of adipose tissue in obese individuals may have immunomodulating properties and pharmacokinetic consequences. The aim of this study was to determine whether body mass index (BMI) affects response to infliximab (IFX) in ankylosing spondylitis (AS) patients. Methods In 155 patients retrospectively included with active AS, the BMI was calculated before initiation of IFX treatment (5 mg/kg intravenously). After 6 months of treatment, changes from baseline in BASDAI, Visual Analogue Scale (VAS) pain, C-reactive protein (CRP) level, and total dose of nonsteroidal antiinflammatory drug (NSAID) were dichotomized with a threshold corresponding to a decrease of 50% of initial level of the measure, into binary variables assessing response to IFX (BASDAI50, VAS50, CRP50, NSAID50). Whether the BMI was predictive of the response to IFX therapy according to these definitions was assessed with logistic regression. Results Multivariate analysis found that a higher BMI was associated with a lower response for BASDAI50 (P = 0.0003; OR, 0.87; 95% CI (0.81 to 0.94)), VAS50 (P < 0.0001; OR, 0.87; 95% CI (0.80 to 0.93)); CRP50 (P = 0.0279; OR, 0.93; 95% CI (0.88 to 0.99)), and NSAID50 (P = 0.0077; OR, 0.91; 95% CI (0.85 to 0.97)), criteria. According to the three WHO BMI categories, similar results were found for BASDAI50 (77.6%, 48.9%, and 26.5%; P < 0.0001), VAS50 (72.6%, 40.4%, and 16.7%; P < 0.0001); CRP50 (87.5%, 65.7%, and 38.5%; P = 0.0001), and NSAID50 (63.2%, 51.5%, and 34.6%; P = 0.06). Conclusions This study provides the first evidence that a high BMI negatively influences the response to IFX in AS. Further prospective studies, including assessment of the fat mass, pharmacokinetics, and adipokines dosages are mandatory to elucidate the role of obesity in AS IFX response.

Publications scientifiques (17) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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