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RhumatologueMédecins généralistes et spécialistes🏥 Libéral temps plein hosp.

M. Docteur LAURENT MESSER

📍 Colmar (68)Mixte💶 Secteur 2RPPS 10002466091
📊 Reconnaissance scientifique : 14/100📝 43 articles publiés📚 HAL (8)

Diplômes

🎓 DES & spécialité ordinale

  • DES Rhumatologie
  • Rhumatologie (SM)

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

14

h articles cités ≥ h fois chacun. Un h de 14 = 14 publications avec 14+ citations.

Citations

871

Publications

43

i10-index

16

Thématiques principales

  • Inflammasome and immune disorders ×10
  • Spondyloarthritis Studies and Treatments ×10
  • Rheumatoid Arthritis Research and Therapies ×6
  • Inflammatory Myopathies and Dermatomyositis ×4
  • Clinical Reasoning and Diagnostic Skills ×4

Affiliations FR : Hopitaux Civils de Colmar · Laboratoire Interdisciplinaire de Physique

Voir sur OpenAlex ↗

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieux de consultation

  • HOPITAL LOUIS PASTEUR

    39 Avenue DE LA LIBERTE, 68024 Colmar

    ☎ 0389124000Hospitalier

  • CABINET PRIVE DU DR LAURENT MESSER

    CENTRE HOSPITALIER LOUIS PASTEUR — 39 AVENUE DE LA LIBERTE, 68024 Colmar

    Libéral

Tarifs & secteur de conventionnement

🟡 Secteur 2 — Honoraires libresSource CNAM (Annuaire santé Ameli)
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Prendre rendez-vous & contact

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (5)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Top publications · les plus citées

  • 1
    Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes

    Arthritis research & therapy · 2009

    📚 62 citations🎯 RCR 1.65🔓 Open Access📄 PDF gratuit ↗
    Lire l'abstract Crossref ↓

    Abstract Introduction In the present study, we investigated the ability of microparticles isolated from synovial fluids from patients with rheumatoid arthritis or osteoarthritis to induce the synthesis and release of key cytokines of B-lymphocyte modulation such as B cell-activating factor, thymic stroma lymphopoietin, and secretory leukocyte protease inhibitor by rheumatoid fibroblast-like synoviocytes. Methods Microparticles were analyzed in synovial fluids from patients with rheumatoid arthritis, osteoarthritis, microcristalline arthritis, and reactive arthritis. In addition, microparticle release after activation from various cell lines (CEM lymphocyte and THP-1 cells) was assessed. Microparticles were isolated by differential centrifugation, and quantitative determinations were carried out by prothrombinase assay after capture on immobilized annexin V. B cell-activating factor, thymic stroma lymphopoietin, and secretory leukocyte protease inhibitor release was evaluated by enzyme-linked immunosorbent assay. Results Microparticles isolated from synovial fluids obtained from rheumatoid arthritis and osteoarthritis patients or microparticles derived from activated THP-1 cells were able to induce B cell-activating factor, thymic stroma lymphopoietin, and secretory leukocyte protease inhibitor release by rheumatoid arthritis fibroblast-like synoviocytes. Conversely, CEM-lymphocytes-derived microparticles generated by treatment with a combination of PHA, PMA and Adt-D did not promote the release of B cell-activating factor but favored the secretion of thymic stroma lymphopoietin and secretory leukocyte protease inhibitor by rheumatoid arthritis fibrobast-like synoviocytes. However, microparticles isolated from actinomycin D-treated CEM lymphocytes were not able to induce B cell-activating factor, thymic stroma lymphopoietin, or secretory leukocyte protease inhibitor release, indicating that microparticles derived from apoptotic T cells do not function as effectors in B-cell activation. Conclusions These results demonstrate that microparticles are signalling structures that may act as specific conveyors in the triggered induction and amplification of autoimmunity. This study also indicates that microparticles have differential effects in the crosstalk between B lymphocytes and target cells of autoimmunity regarding the parental cells from which they derive.

  • 2
    Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept

    Annals of the rheumatic diseases · 2020

    📚 56 citations🎯 RCR 2.63Top 19% NIH🔓 Open Access
  • 3
    In antisynthetase syndrome, ACPA are associated with severe and erosive arthritis: an overlapping rheumatoid arthritis and antisynthetase syndrome

    Medicine · 2015

    📚 43 citations🎯 RCR 2.03🔓 Open Access

Publications scientifiques (29) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal20

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Anti-TNF2

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Anti-IL-171

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Anti-IL-231

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Biomarqueurs / Auto-Ac1

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Gériatrie1

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Goutte1

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Lupus1

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Revue générale1

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Spondyloarthrite1

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