Docteur PASCAL JACOB

Bibliographie

• Active skeleton for bacteria modelling

  2016

  ArticleComputer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

• Histoire[s] de cirque

  2016

  ArticleChroniques de la Bibliothèque nationale de France

• Particle detection and tracking in fluorescence time-lapse imaging: a contrario approach

  2016

  ArticleMachine Vision and Applications

• Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect

  2013

  ArticlePLoS Computational Biology

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

• HOPITAL MAISON BLANCHE CHU REIMS

  45 Rue COGNACQ JAY, 51092 Reims

  ☎ 0326787878Hospitalier🏥 Centre CHU ↗🏥 Voir cet établissement

• CABINET DE RHUMATOLOGIE DU DR P. JACOB

  CABINET DE RHUMATOLOGIE DU DR P. JACOB — 1 BOULEVARD DE LA MOTTE, 51200 Épernay

  ☎ 0326552118Libéral
  57 m60 m67 m79 m

  © OpenStreetMap · Photos Wikimedia Commons (CC)

  📷 Street View ↗🗺️ Maps ↗OSM ↗

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  The use of intravenous bisphosphonate therapy to treat vertebral fractures due to osteoporosis among boys with Duchenne muscular dystrophy

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012

  📚 95 citations🎯 RCR 3.76Top 12% NIH
• 2

  Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis

  Arthritis & rheumatology (Hoboken, N.J.) · 2020

  📚 69 citations🎯 RCR 3.96Top 11% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  ObjectiveAlterations of the gut microbiota have been implicated in many forms of arthritis, but an examination of cartilage microbial patterns has not been performed. This study was undertaken to characterize the microbial DNA profile of articular cartilage and determine changes associated with osteoarthritis (OA).MethodsWe performed 16S ribosomal RNA gene deep sequencing on eroded and intact cartilage samples from knee OA patients (n = 21 eroded and 21 intact samples) and hip OA patients (n = 34 eroded and 33 intact samples) and cadaver controls (n = 10 knee samples and 10 hip samples). Microbial DNA diversity was assessed, groups were compared, and metagenomic profiles were reconstructed. Confirmation was performed in an independent cohort by clade‐specific quantitative polymerase chain reaction. Findings in human cartilage were compared to those in cartilage from OA‐susceptible C57BL/6 (B6) mice and OA‐resistant MRL/MpJ (MRL) mice. Germ‐free B6 mouse cartilage was analyzed as a methodologic control.ResultsAlpha diversity was reduced in human OA versus control samples (P < 0.0001), and in hip versus knee samples (P < 0.0001). Numerous clades were different in human OA versus control samples, and similar findings were noted in comparisons of murine B6 versus MRL mice. Hip samples were microbiologically distinct from knee samples. OA microbial DNA demonstrated increased gram‐negative constituents (P = 0.02). Functional analysis demonstrated increases in lipopolysaccharide production (P = 9.9 × 10−3), phosphatidylinositol signaling (P = 4.2 × 10−4), and nitrogen metabolism (P = 8 × 10−3) and decreases in sphingolipid metabolism (P = 7.7 × 10−4) associated with OA.ConclusionOur study reveals a microbial DNA signature in human and mouse cartilage. Alterations in this signature, including increases in gram‐negative constituents, occur during the development and progression of human OA. Furthermore, our findings indicate that strain‐specific signatures exist within mouse cartilage that mirror human patterns. Further study of the establishment and potential pathogenic role of these DNA signatures is needed.

• 3

  PAI1 mediates fibroblast-mast cell interactions in skin fibrosis

  The Journal of clinical investigation · 2018

  📚 56 citations🎯 RCR 2.41Top 21% NIH🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (17) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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