Docteur PASCALE GUILLOT
31ans d'exercice (thèse 1995)
✨ Profil synthétique
IA · 29/04/2026Le Docteur Pascale Guillot est un rhumatologue hospitalier à Nantes, avec une production scientifique importante (h-index de 42 et 288 publications). Ses recherches portent notamment sur les cellules souches mésenchymateuses, les infections orthopédiques, les cellules souches pluripotentes, la santé osseuse et l'ostéoporose. Elle a également publié sur des essais cliniques, la génétique, l'arthrite juvénile et l'activité physique en rééducation.
Expertises présumées
- Ostéoporose
- Arthrite juvénile
- Essais cliniques en rhumatologie
- Rééducation et activité physique
- Génétique des maladies rhumatismales
- Santé osseuse
- Thérapies cellulaires en rhumatologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
42
h articles cités ≥ h fois chacun. Un h de 42 = 42 publications avec 42+ citations.
Citations
5 361
Publications
288
i10-index
90
Thématiques principales
- Mesenchymal stem cell research ×31
- Orthopedic Infections and Treatments ×22
- Pluripotent Stem Cells Research ×20
- Renal and related cancers ×17
- Bone health and osteoporosis research ×15
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Surgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomised controlled trial
2025ArticleThe Lancet. Diabetes & Endocrinology
Real-world efficacy and safety of Burosumab in tumor-induced Osteomalacia: case series from an early access program
2025ArticleJBMR Plus
Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia
2024ArticleJournal of Clinical Endocrinology and Metabolism
Do men improve their bone mineral density 1 year after parathyroidectomy for primary hyperparathyroidism? Results of a prospective study
2024ArticleSurgery
Survey of adolescents’ needs and parents’ views on sexual health in juvenile idiopathic arthritis
2023ArticlePediatric Rheumatology
Inpatient Rehabilitation during Intensive Refeeding in Severe Anorexia Nervosa
2022ArticleNutrients
123I Scintigraphy Mirror Image of Graves Disease Induced by Radioiodine Treatment for Toxic Adenoma
2022ArticleClinical Nuclear Medicine
Imatinib, a New Adjuvant Medical Treatment for Multifocal Villonodular Synovitis Associated to Noonan Syndrome: A Case Report and Literature Review
2022ArticleFrontiers in Medicine
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Livres & ouvrages
Source : Google Books — filtre catégories médicales/santé/sciences.
Localisation
Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.
Lieux de consultation
CHU DE NANTES SITE HOTEL DIEU HME
1 Place ALEXIS RICORDEAU, 44093 Nantes
SERVICE DE SOINS SNCF
PORTE 3 — 27 Boulevard DE STALINGRAD, 44000 Nantes
☎ 0240081633Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach
Molecular therapy : the journal of the American Society of Gene Therapy · 2012
- 2Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues
Journal of the Royal Society, Interface · 2010
Lire l'abstract Crossref ↓
Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these cells differ on many biological aspects such as growth kinetics, morphology, immunophenotype, differentiation potential and engraftment capacityin vivo. Despite these differences, FSCs appear to be more primitive and have greater multi-potentiality than their adult counterparts. For example, foetal blood haemopoietic stem cells proliferate more rapidly than those found in cord blood or adult bone marrow. These features have led to FSCs being investigated for pre- and post-natal cell therapy and regenerative medicine applications. The cells have been used in pre-clinical studies to treat a wide range of diseases such as skeletal dysplasia, diaphragmatic hernia and respiratory failure, white matter damage, renal pathologies as well as cancers. Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status.
- 3Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential
Basic research in cardiology · 2020
Lire l'abstract Crossref ↓
AbstractMesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of impurities. Here, we studied the cardioprotective and proangiogenic activities of size-exclusion chromatography-purified sEVs secreted from human foetal amniotic fluid stem cells (SS-hAFSCs), possessing superior functional potential to that of adult MSCs. We demonstrated for the first time that highly pure (up to 1.7 × 1010 particles/µg protein) and thoroughly characterised SS-hAFSC sEVs protect rat hearts from ischaemia–reperfusion injury in vivo when administered intravenously prior to reperfusion (38 ± 9% infarct size reduction,p < 0.05). SS-hAFSC sEVs did not protect isolated primary cardiomyocytes in models of simulated ischaemia–reperfusion injury in vitro, indicative of indirect cardioprotective effects. SS-hAFSC sEVs were not proangiogenic in vitro, although they markedly stimulated endothelial cell migration. Additionally, sEVs were entirely responsible for the promigratory effects of the medium conditioned by SS-hAFSC. Mechanistically, sEV-induced chemotaxis involved phosphatidylinositol 3-kinase (PI3K) signalling, as its pharmacological inhibition in treated endothelial cells reduced migration by 54 ± 7% (p < 0.001). Together, these data indicate that SS-hAFSC sEVs have multifactorial beneficial effects in a myocardial infarction setting.
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal35
▼
Transversal35
▼- Radius Bone Mineral Density Measurement Is Essential During Initial PHPT Workup: Results of a Retrospective Study on 400 Patients
World journal of surgery · 2026 · Journal Article
Loison M, Wargny M, Caillard C, Guillot P, et al.
- Isolation, Characterization, and In Vitro Cell Studies of Plant-Based Exosome-like Nanovesicles for Treatment of Early Osteoarthritis
International journal of molecular sciences · 2025 · Journal Article
Rashidi N, Liu C, Guillot PV, Tamaddon M
📚 9 cit.🎯 RCR 3.82 - Pleiotropic effects of a recessive Col1a2 mutation occurring in a mouse model of severe osteogenesis imperfecta
PloS one · 2025 · Journal Article
Corcelli M, Sagar R, Petzendorfer E, Hasan MM, et al.
📚 1 cit. - Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene
Calcified tissue international · 2024 · Journal Article
Mancini M, Chapurlat R, Isidor B, Desjonqueres M, et al.
📚 3 cit. - Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia
The Journal of clinical endocrinology and metabolism · 2024 · Journal Article
Frey S, Gérard M, Guillot P, Wargny M, et al.
📚 6 cit.🎯 RCR 2.27🩺 Clinique - Do men improve their bone mineral density 1 year after parathyroidectomy for primary hyperparathyroidism? Results of a prospective study
Surgery · 2024 · Journal Article
Frey S, Guillot P, Wargny M, Gérard M, et al.
📚 3 cit.🎯 RCR 1.15 - Inpatient Rehabilitation during Intensive Refeeding in Severe Anorexia Nervosa
Nutrients · 2022 · Journal Article
Dauty M, Menu P, Jolly B, Lambert S, et al.
📚 5 cit.🔬→🩺 Translationnel - 123I Scintigraphy Mirror Image of Graves Disease Induced by Radioiodine Treatment for Toxic Adenoma
Clinical nuclear medicine · 2022 · Case Reports
Lugat A, Drui D, Bach-Ngohou K, Guillot P, et al.
- Personalized Massive Open Online Course for Childhood Cancer Survivors: Behind the Scenes
Applied clinical informatics · 2021 · Journal Article
Berger C, Casagranda L, Sudour-Bonnange H, Massoubre C, et al.
📚 9 cit. - Acromegaly is associated with vertebral deformations but not vertebral fractures: Results of a cross-sectional monocentric study
Joint bone spine · 2020 · Journal Article
Plard C, Hochman C, Hadjadj S, Le Goff B, et al.
📚 12 cit.🔬→🩺 Translationnel - Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential
Basic research in cardiology · 2020 · Journal Article
Takov K, He Z, Johnston HE, Timms JF, et al.
📚 75 cit.🎯 RCR 4.34 - Pain catastrophising worsens RAPID3 in all rheumatologic conditions
Clinical and experimental rheumatology · 2019 · Journal Article
Berthelot JM, Bart G, Darrieutort-Lafitte C, Le Goff B, et al.
📚 4 cit. - Human mid-trimester amniotic fluid (stem) cells lack expression of the pluripotency marker OCT4A
Scientific reports · 2019 · Journal Article
Vlahova F, Hawkins KE, Ranzoni AM, Hau KL, et al.
📚 9 cit. - Contribution of ultrasound to diagnosing a phosphaturic mesenchymal tumor
Joint bone spine · 2018 · Case Reports
Busquet F, Gahier-Penhoat M, Lescour V, Maugars Y, et al.
📚 5 cit. - Embryonic Stem Cell-Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain
Stem cells translational medicine · 2018 · Journal Article
Hawkins KE, Corcelli M, Dowding K, Ranzoni AM, et al.
📚 70 cit.🎯 RCR 3.26 - The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time
Stem cell research & therapy · 2018 · Journal Article
Rahman MS, Spitzhorn LS, Wruck W, Hagenbeck C, et al.
📚 18 cit. - TGFβ-induced osteogenic potential of human amniotic fluid stem cells via CD73-generated adenosine production
Scientific reports · 2017 · Journal Article
Hau KL, Ranzoni AM, Vlahova F, Hawkins K, et al.
📚 9 cit. - Contribution of 18-FDG PET/CT to brown tumor detection in a patient with primary hyperparathyroidism
Joint bone spine · 2017 · Case Reports
Gahier Penhoat M, Drui D, Ansquer C, Mirallie E, et al.
📚 17 cit.🎯 RCR 1.26 - Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency
Molecular therapy : the journal of the American Society of Gene Therapy · 2017 · Journal Article
Hawkins KE, Moschidou D, Faccenda D, Wruck W, et al.
📚 8 cit. - Rheumatology: Craft, industry, or both?
Joint bone spine · 2017 · Editorial
Berthelot JM, Guillot P, Le Goff B, Maugars Y
📚 1 cit. - Counteracting bone fragility with human amniotic mesenchymal stem cells
Scientific reports · 2016 · Journal Article
Ranzoni AM, Corcelli M, Hau KL, Kerns JG, et al.
📚 21 cit. - Induced pluripotent stem (iPS) cells from human fetal stem cells
Best practice & research. Clinical obstetrics & gynaecology · 2016 · Journal Article
Guillot PV
📚 6 cit. - [Study of vitamin D supplementation in people over 65 years in primary care]
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2015 · Journal Article
Breysse C, Guillot P, Berrut G
📚 6 cit.🔬→🩺 Translationnel - Immune regulatory properties of CD117(pos) amniotic fluid stem cells vary according to gestational age
Stem cells and development · 2015 · Clinical Trial
Di Trapani M, Bassi G, Fontana E, Giacomello L, et al.
📚 37 cit.🎯 RCR 1.44🩺 Clinique - In utero therapy for congenital disorders using amniotic fluid stem cells
Frontiers in pharmacology · 2014 · Journal Article
Ramachandra DL, Shaw SS, Shangaris P, Loukogeorgakis S, et al.
📚 23 cit. - Stem cell therapy for neonatal brain injury
Clinics in perinatology · 2014 · Journal Article
Fleiss B, Guillot PV, Titomanlio L, Baud O, et al.
📚 37 cit.🎯 RCR 1.47 - Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis
Stem cells and development · 2014 · Journal Article
Brady K, Dickinson SC, Guillot PV, Polak J, et al.
📚 44 cit.🎯 RCR 1.81 - Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta
Stem cells and development · 2014 · Journal Article
Jones GN, Moschidou D, Abdulrazzak H, Kalirai BS, et al.
📚 30 cit.🎯 RCR 1.10 - Induced pluripotent stem (iPS) cells from human fetal stem cells (hFSCs)
Organogenesis · 2013 · Journal Article
Spinelli V, Guillot PV, De Coppi P
📚 15 cit. - Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics
Stem cells and development · 2013 · Journal Article
Moschidou D, Mukherjee S, Blundell MP, Jones GN, et al.
📚 50 cit.🎯 RCR 1.85🔬→🩺 Translationnel - Placenta as a reservoir of stem cells: an underutilized resource?
British medical bulletin · 2013 · Journal Article
Pipino C, Shangaris P, Resca E, Zia S, et al.
📚 60 cit.🎯 RCR 2.28 - Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach
Molecular therapy : the journal of the American Society of Gene Therapy · 2012 · Journal Article
Moschidou D, Mukherjee S, Blundell MP, Drews K, et al.
📚 118 cit.🎯 RCR 3.53🔬→🩺 Translationnel - Vitamin D insufficiency: evaluation of an oral standardized supplementation using 100,000 IU vials of cholecalciferol, depending on initial serum level of 25OH vitamin D
Joint bone spine · 2012 · Journal Article
Rouillon V, Dubourg G, Gauvain JB, Baron D, et al.
📚 5 cit. - The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells
Epigenetics · 2011 · Journal Article
Frost J, Monk D, Moschidou D, Guillot PV, et al.
📚 34 cit.🔬→🩺 Translationnel - Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues
Journal of the Royal Society, Interface · 2010 · Journal Article
Abdulrazzak H, Moschidou D, Jones G, Guillot PV
📚 96 cit.🎯 RCR 2.84🔬→🩺 Translationnel
Essai clinique2
▼
Essai clinique2
▼- Parathyroid near-infrared autofluorescence use for parathyroidectomy in mild primary hyperparathyroidism: Results from a randomized monocentric trial
Surgery · 2025 · Journal Article
Frey S, Bannani S, Caillard C, Le Bras M, et al.
📚 2 cit.🩺 Clinique - Randomised study versus control group of customised therapeutic education for patients in follow-up for rheumatoid arthritis
Joint bone spine · 2016 · Comparative Study
Pot-Vaucel M, Aubert MP, Guillot P, Glémarec J, et al.
📚 11 cit.🩺 Clinique
Génétique2
▼
Génétique2
▼- Primary Osteoporosis in Young Adults: Genetic Basis and Identification of Novel Variants in Causal Genes
JBMR plus · 2018 · Journal Article
Collet C, Ostertag A, Ricquebourg M, Delecourt M, et al.
📚 47 cit.🎯 RCR 1.94 - Trisomy 21 mid-trimester amniotic fluid induced pluripotent stem cells maintain genetic signatures during reprogramming: implications for disease modeling and cryobanking
Cellular reprogramming · 2014 · Journal Article
Pipino C, Mukherjee S, David AL, Blundell MP, et al.
📚 10 cit.
Ostéoporose2
▼
Ostéoporose2
▼- Long-term follow up after denosumab treatment for osteoporosis - rebound associated with hypercalcemia, parathyroid hyperplasia, severe bone mineral density loss, and multiple fractures: a case report
Journal of medical case reports · 2020 · Case Reports
Maugars Y, Guillot P, Glémarec J, Berthelot JM, et al.
📚 10 cit. - Multiple Vertebral Osteonecroses (Kümmell's Disease) After 10 Years on Denosumab: Is Osteocyte Apoptosis to Blame?
Calcified tissue international · 2018 · Journal Article
Maugars Y, Bart G, Guillot P, Chemel-Mary M, et al.
📚 7 cit.🔬→🩺 Translationnel
Revue générale2
▼
Revue générale2
▼- Imatinib, a New Adjuvant Medical Treatment for Multifocal Villonodular Synovitis Associated to Noonan Syndrome: A Case Report and Literature Review
Frontiers in medicine · 2021 · Case Reports
Dalla-Torre R, Crenn V, Menu P, Isidor B, et al.
📚 1 cit. - Cystic angiomatosis, a heterogeneous condition: Four new cases and a literature review
Medicine · 2016 · Case Reports
Najm A, Soltner-Neel E, Le Goff B, Guillot P, et al.
📚 17 cit.🎯 RCR 1.48
Activité physique / Rééducation1
▼
Activité physique / Rééducation1
▼- Association between Bone Mineral Density and Fat Mass Independent of Lean Mass and Physical Activity in Women Aged 75 or Older
Nutrients · 2021 · Journal Article
Mathieu M, Guillot P, Riaudel T, Boureau AS, et al.
📚 10 cit.
Arthrite juvénile1
▼
Arthrite juvénile1
▼- Survey of adolescents' needs and parents' views on sexual health in juvenile idiopathic arthritis
Pediatric rheumatology online journal · 2023 · Journal Article
Savel C, Chausset A, Berland P, Guiguet-Auclair C, et al.
📚 1 cit.
Case report / série1
▼
Case report / série1
▼- Imatinib, a New Adjuvant Medical Treatment for Multifocal Villonodular Synovitis Associated to Noonan Syndrome: A Case Report and Literature Review
Frontiers in medicine · 2021 · Case Reports
Dalla-Torre R, Crenn V, Menu P, Isidor B, et al.
📚 1 cit.
Corticothérapie1
▼
Corticothérapie1
▼- Feasibility and safety of ultrasound-guided caudal epidural glucocorticoid injections
Joint bone spine · 2010 · Journal Article
Blanchais A, Le Goff B, Guillot P, Berthelot JM, et al.
📚 30 cit.🎯 RCR 1.42🔬→🩺 Translationnel
Gériatrie1
▼
Gériatrie1
▼- [Nutrition and osteoporosis in elderly]
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2011 · English Abstract
Riaudel T, Guillot P, De Decker L, Gouraud-Tanguy A, et al.
📚 5 cit.
Ostéomalacie1
▼
Ostéomalacie1
▼- Real-world efficacy and safety of burosumab in tumor-induced osteomalacia: case series from an early access program
JBMR plus · 2025 · Case Reports
Cadiou S, Chapurlat R, Couture G, Guggenbuhl P, et al.
📚 4 cit.
Pharmacovigilance1
▼
Pharmacovigilance1
▼- Feasibility and safety of ultrasound-guided caudal epidural glucocorticoid injections
Joint bone spine · 2010 · Journal Article
Blanchais A, Le Goff B, Guillot P, Berthelot JM, et al.
📚 30 cit.🎯 RCR 1.42🔬→🩺 Translationnel
Spondyloarthrite1
▼
Spondyloarthrite1
▼- Three-dimensional versus two-dimensional ultrasonographic assessment of peripheral enthesitis in spondylarthritis
Clinical rheumatology · 2014 · Comparative Study
Mérot O, Guillot P, Maugars Y, Le Goff B
📚 10 cit.
Tendinopathies & SCC1
▼
Tendinopathies & SCC1
▼- Assessment of calcific tendonitis of rotator cuff by ultrasonography: comparison between symptomatic and asymptomatic shoulders
Joint bone spine · 2010 · Clinical Trial
Le Goff B, Berthelot JM, Guillot P, Glémarec J, et al.
📚 55 cit.🎯 RCR 2.76🩺 Clinique
Datasets & protocoles partagés
Wild-type5 3D
Dataset2018figshare3D microCT reconstruction of mouse tibiae-wild-type5
Wild-type6 3D
Dataset2018figshare3D microCT reconstruction of mouse tibiae-wild-type6
MicroCT of mouse tibiae-oim+AFSC6
Dataset2018figshareMicroCT of mouse tibiae-oim+AFSC6
MicroCT of mouse tibiae-oim+AFSC5
Dataset2018figshareMicroCT of mouse tibiae-oim+AFSC5
MicroCT of mouse tibiae-wild-type6
Dataset2018figshareMicroCT of mouse tibiae-wild-type6
OIM+AFSCs3 3D
Dataset2018figshare3D microCT reconstruction of mouse tibiae-OIM+AFSCs3
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
