Docteur LAURENT GRANGE
✨ Profil synthétique
IA · 29/04/2026Le Docteur Laurent Grange est un rhumatologue hospitalier à La Tronche, avec une production scientifique significative dans le domaine de la rhumatologie. Ses recherches portent principalement sur les thérapies et les mécanismes de l'arthrose, la spondylarthrite, ainsi que les médiateurs inflammatoires et les effets des anti-inflammatoires non stéroïdiens. Avec un h-index de 23 et 165 publications, il démontre une expertise notable dans ces domaines.
Expertises présumées
- Rhumatoides
- Osteoarthrite
- Spondylarthrite
- Thérapies anti-TNF
- Essais cliniques
- Évaluation de la qualité de vie
- Économie de la santé
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
23
h articles cités ≥ h fois chacun. Un h de 23 = 23 publications avec 23+ citations.
Citations
1 823
Publications
165
i10-index
39
Thématiques principales
- Rheumatoid Arthritis Research and Therapies ×42
- Healthcare Systems and Practices ×25
- Osteoarthritis Treatment and Mechanisms ×22
- Spondyloarthritis Studies and Treatments ×22
- Inflammatory mediators and NSAID effects ×13
Affiliations FR : Centre Hospitalier Universitaire de Grenoble · Laboratoire Rhéologie et Procédés
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Impact of axial spondylarthritis on quality of life: results from the European Map of Axial Spondyloarthritis (EMAS) study in France
2022ArticleJournal of Rheumatology
Development and real-life use assessment of a self-management smartphone application for patients with inflammatory arthritis. A user-centred step-by-step approach
2022ArticlePLoS ONE
Development and Validation of a Self-Administered Questionnaire Measuring Essential Knowledge in Patients with Axial Spondyloarthritis
2022ArticleThe Journal of rheumatology
Barriers and Expectations for Patients in Post-Osteoporotic Fracture Care in France: The EFFEL Study
2021ArticleValue in Health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Real-world care for individuals aged over fifty with fractures in France: Evidence for a wide care gap–The EPIFRACT Study
2020ArticleJoint Bone Spine
Part of pain labelled neuropathic in rheumatic disease might be rather nociplastic
2020ArticleRMD Open : Rheumatic & Musculoskeletal Diseases
Recommendations of the French Society of Rheumatology on pharmacological treatment of knee osteoarthritis
2020ArticleJoint Bone Spine
Le savoir nécessaire aux patients atteints de polyarthrite rhumatoïde ou de spondyloarthrite. Résultats d’une enquête multicentrique française auprès de professionnels de santé et de patients
2020ArticleRevue du Rhumatisme
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Localisation
Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.
Lieu de consultation
HOPITAL NORD - CHU38
Boulevard DE LA CHANTOURNE, 38700 La Tronche
☎ 0476765026Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases
Rheumatology (Oxford, England) · 2010
📚 98 citations🎯 RCR 2.66Top 19% NIH - 2A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab
Arthritis research & therapy · 2007
Lire l'abstract Crossref ↓
AbstractThe goal of the present study was to record changes in bone mineral density (BMD) and markers of bone turnover in patients with rheumatoid arthritis (RA) who were treated with methotrexate combined (or not combined) with infliximab. Included were 90 patients with RA who required anti-TNF-α therapy with infliximab because of persistent active disease despite treatment with methotrexate. The historical control group included 99 patients with RA who were treated with methotrexate at a time when anti-TNF-α treatment was not yet available. Lumbar and femoral neck BMD was measured using dual energy X-ray absorptiometry at baseline and 1 year later. Osteocalcin, C-terminal cross-linked telopeptide of type I collagen, parathyroid hormone and 25-hydroxycholecalciferol were measured in plasma at baseline and 1 year later. At 1 year BMD had decreased in the control group at spine (P < 0.01) and femoral neck (P < 0.001). In contrast, BMD at spine and femoral neck did not change after 1 year of infliximab treatment. At the same time point, no change in bone remodelling markers was observed. No association was observed between clinical response and changes in BMD, indicating that even those who did not respond clinically did not lose bone over a 1-year period. These data confirm the BMD decrease observed in RA patients treated with methotrexate alone. This bone loss was prevented by infliximab therapy. Importantly, this beneficial effect was also observed in apparent nonresponders.
- 3Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
Experimental gerontology · 2018
📚 68 citations🎯 RCR 3.54Top 13% NIH
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal35
▼
Transversal35
▼- Morbi-mortality of obese patients with systemic sclerosis: A comparative study
La Revue de medecine interne · 2026 · Journal Article
Grange L, Chaigne B, Casadevall M, Cohen P, et al.
- [An invasive cutaneous aspergillosis during a granulomatosis with polyangiitis]
La Revue de medecine interne · 2024 · Case Reports
Agade A, Habougit C, Chol C, Gaultier JB, et al.
- Development and Validation of a Self-Administered Questionnaire Measuring Essential Knowledge in Patients With Axial Spondyloarthritis
The Journal of rheumatology · 2023 · Journal Article
Beauvais C, Pereira B, Pham T, Sordet C, et al.
📚 6 cit.🎯 RCR 1.51 - Development and validation of a self-administered questionnaire measuring essential knowledge in patients with rheumatoid arthritis
Rheumatology international · 2022 · Journal Article
Rodère M, Pereira B, Soubrier M, Fayet F, et al.
📚 4 cit. - The use of non-steroidal anti-inflammatory drugs (NSAIDs) in COVID-19
NPJ primary care respiratory medicine · 2022 · Journal Article
Kushner P, McCarberg BH, Grange L, Kolosov A, et al.
📚 48 cit.🎯 RCR 4.73🔬→🩺 Translationnel - Development and real-life use assessment of a self-management smartphone application for patients with inflammatory arthritis. A user-centred step-by-step approach
PloS one · 2022 · Journal Article
Beauvais C, Pham T, Montagu G, Gleizes S, et al.
📚 4 cit. - Barriers and Expectations for Patients in Post-Osteoporotic Fracture Care in France: The EFFEL Study
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022 · Journal Article
Launois R, Cabout E, Benamouzig D, Velpry L, et al.
📚 7 cit. - [Rheumatoid arthritis]
La Revue du praticien · 2022 · Journal Article
Grange L, Alliot-Launois F
📚 2 cit. - Assessment of impact of the COVID-19 pandemic from the perspective of patients with rheumatic and musculoskeletal diseases in Europe: results from the REUMAVID study (phase 1)
RMD open · 2021 · Journal Article
Garrido-Cumbrera M, Marzo-Ortega H, Christen L, Plazuelo-Ramos P, et al.
📚 56 cit.🎯 RCR 4.88🔬→🩺 Translationnel - Resolution of ocular and mediastinal sarcoidosis after Janus kinase inhibitor therapy for concomitant rheumatoid arthritis
Clinical and experimental rheumatology · 2021 · Letter
Sejournet L, Kodjikian L, Grange L, Grumet P, et al.
📚 5 cit. - Recommendations of the French Society of Rheumatology on pharmacological treatment of knee osteoarthritis
Joint bone spine · 2020 · Journal Article
Sellam J, Courties A, Eymard F, Ferrero S, et al.
📚 61 cit.🎯 RCR 4.84🔬→🩺 Translationnel - Dysphagia in a patient with ankylosing spondylitis. Comment on « Esophagus type cervical spondylosis » by Ma et al. Joint Bone Spine 2019;86:643
Joint bone spine · 2020 · Letter
Fourcade G, Baillet A, Grange L, Gastaldi R
📚 2 cit. - Part of pain labelled neuropathic in rheumatic disease might be rather nociplastic
RMD open · 2020 · Journal Article
Bailly F, Cantagrel A, Bertin P, Perrot S, et al.
📚 55 cit.🎯 RCR 4.03🔬→🩺 Translationnel - Self-reported competencies and educational needs of rheumatology nurses: Results of a national survey
Joint bone spine · 2020 · Letter
Beauvais C, Gossec L, Mulliez A, Fayet F, et al.
📚 1 cit. - Essential knowledge for patients with rheumatoid arthritis or spondyloarthritis: Results of a multicentric survey in France among health professionals and patients
Joint bone spine · 2019 · Comparative Study
Beauvais C, Rodère M, Pereira B, Legoupil N, et al.
📚 12 cit. - Gait as predictor of physical function in axial spondyloarthritis: the prospective longitudinal FOLOMI (Function, Locomotion, Measurement, Inflammation) study protocol
Rheumatology international · 2019 · Clinical Trial Protocol
Soulard J, Vuillerme N, Gaudin P, Grange L, et al.
📚 8 cit.🩺 Clinique - Assessment of the adherence to disease-modifying drugs in patients with chronic inflammatory rheumatic diseases: Results of a survey of 1594 patients
Joint bone spine · 2019 · Journal Article
López-Medina C, Moltó A, Gérald F, Dubremetz M, et al.
📚 10 cit.🩺 Clinique - Prealbumin, platelet factor 4 and S100A12 combination at baseline predicts good response to TNF alpha inhibitors in rheumatoid arthritis
Joint bone spine · 2019 · Journal Article
Nguyen MVC, Baillet A, Romand X, Trocmé C, et al.
📚 17 cit.🔬→🩺 Translationnel - Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
Experimental gerontology · 2018 · Journal Article
Drevet S, Gavazzi G, Grange L, Dupuy C, et al.
📚 68 cit.🎯 RCR 3.54 - [Towards real recognition of osteoarthritis]
Revue de l'infirmiere · 2016 · Journal Article
Grange L
📚 1 cit. - Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire
The Journal of rheumatology · 2016 · Journal Article
Betegnie AL, Gauchet A, Lehmann A, Grange L, et al.
📚 34 cit.🎯 RCR 1.86🔬→🩺 Translationnel - Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies
Autoimmunity · 2016 · Journal Article
Clavarino G, Adriouach S, Quesada JL, Clay M, et al.
📚 19 cit. - IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes
Osteoarthritis and cartilage · 2015 · Journal Article
Rousset F, Hazane-Puch F, Pinosa C, Nguyen MV, et al.
📚 63 cit.🎯 RCR 2.60🔬→🩺 Translationnel - [NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis]
Bulletin de l'Academie nationale de medecine · 2015 · Journal Article
Morel F, Rousset F, Vu Chuong Nguyen M, Trocme C, et al.
📚 15 cit. - [NADPH oxidases, Nox: new isoenzymes family]
Medecine sciences : M/S · 2015 · Journal Article
Chuong Nguyen MV, Lardy B, Paclet MH, Rousset F, et al.
📚 19 cit. - Results of a human factors experiment of the usability and patient acceptance of a new autoinjector in patients with rheumatoid arthritis
Patient preference and adherence · 2014 · Journal Article
Schwarzenbach F, Dao Trong M, Grange L, Laurent PE, et al.
📚 36 cit.🎯 RCR 1.62🔬→🩺 Translationnel - Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes
PloS one · 2013 · Journal Article
Rousset F, Nguyen MV, Grange L, Morel F, et al.
📚 50 cit.🎯 RCR 1.86🔬→🩺 Translationnel - Factors influencing concordance between clinical and ultrasound findings in rheumatoid arthritis
The Journal of rheumatology · 2013 · Journal Article
Le Boedec M, Jousse-Joulin S, Ferlet JF, Marhadour T, et al.
📚 19 cit.🔬→🩺 Translationnel - Can we improve the diagnosis of spondyloarthritis in patients with uncertain diagnosis? The EchoSpA prospective multicenter French cohort
Joint bone spine · 2012 · Evaluation Study
D'Agostino MA, Saraux A, Chary-Valckenaere I, Marcelli C, et al.
📚 9 cit.🔬→🩺 Translationnel - Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)
The Journal of rheumatology · 2010 · Journal Article
Marhadour T, Jousse-Joulin S, Chalès G, Grange L, et al.
📚 50 cit.🎯 RCR 1.84🔬→🩺 Translationnel - Reproducibility of joint swelling assessment by sonography in patients with long-lasting rheumatoid arthritis (SEA-Repro study part II)
The Journal of rheumatology · 2010 · Journal Article
Jousse-Joulin S, d'Agostino MA, Marhadour T, Albert JD, et al.
📚 26 cit.🔬→🩺 Translationnel - Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases
Rheumatology (Oxford, England) · 2010 · Journal Article
Baillet A, Trocmé C, Berthier S, Arlotto M, et al.
📚 98 cit.🎯 RCR 2.66🔬→🩺 Translationnel - Is dynamic exercise beneficial in patients with rheumatoid arthritis?
Joint bone spine · 2008 · Journal Article
Gaudin P, Leguen-Guegan S, Allenet B, Baillet A, et al.
📚 28 cit.🎯 RCR 1.02🔬→🩺 Translationnel - Radiculopathy as a manifestation of Langerhans' cell histiocytosis
Joint bone spine · 2007 · Case Reports
Baillet A, Grange L, Lafaix PA, Gaudin P, et al.
📚 4 cit. - NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression
Antioxidants & redox signaling · 2006 · Journal Article
Grange L, Nguyen MV, Lardy B, Derouazi M, et al.
📚 65 cit.🎯 RCR 1.66🔬→🩺 Translationnel
Essai clinique4
▼
Essai clinique4
▼- Efficacy and safety of a millimetre wave medical device for pain neuromodulation in peripheral OA: a crossover randomized trial
Rheumatology (Oxford, England) · 2026 · Journal Article
Maindet C, Giai J, Leroy C, Proust M, et al.
📚 1 cit.🩺 Clinique - Efficacy of self-management program associated with a spa therapy for knee osteoarthritis patients (GETT 2): a research protocol for a randomized trial
Trials · 2023 · Clinical Trial Protocol
Goldstein A, Lanhers C, Gay C, Dubourg K, et al.
🩺 Clinique - An e-health interactive self-assessment website (Sanoia(®)) in rheumatoid arthritis. A 12-month randomized controlled trial in 320 patients
Joint bone spine · 2018 · Journal Article
Gossec L, Cantagrel A, Soubrier M, Berthelot JM, et al.
📚 40 cit.🎯 RCR 2.72🩺 Clinique - A dynamic exercise programme to improve patients' disability in rheumatoid arthritis: a prospective randomized controlled trial
Rheumatology (Oxford, England) · 2009 · Journal Article
Baillet A, Payraud E, Niderprim VA, Nissen MJ, et al.
📚 60 cit.🎯 RCR 2.32🩺 Clinique
Revue générale3
▼
Revue générale3
▼- Fc receptors gone wrong: A comprehensive review of their roles in autoimmune and inflammatory diseases
Autoimmunity reviews · 2022 · Journal Article
Chalayer E, Gramont B, Zekre F, Goguyer-Deschaumes R, et al.
📚 38 cit.🎯 RCR 3.27 - Challenges of autoimmune rheumatic disease treatment during the COVID-19 pandemic: A review
Therapie · 2020 · Journal Article
Grange L, Guilpain P, Truchetet ME, Cracowski JL, et al.
📚 9 cit.🔬→🩺 Translationnel - [Bisphosphonates-associated osteonecrosis of the jaw: review on reported cases]
Therapie · 2007 · English Abstract
Gering A, Grange L, Villier C, Woeller A, et al.
📚 9 cit.
Anti-TNF2
▼
Anti-TNF2
▼- Apolipoprotein A-I and platelet factor 4 are biomarkers for infliximab response in rheumatoid arthritis
Annals of the rheumatic diseases · 2009 · Journal Article
Trocmé C, Marotte H, Baillet A, Pallot-Prades B, et al.
📚 66 cit.🎯 RCR 1.88🔬→🩺 Translationnel - A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab
Arthritis research & therapy · 2007 · Clinical Trial
Marotte H, Pallot-Prades B, Grange L, Gaudin P, et al.
📚 96 cit.🎯 RCR 2.62🩺 Clinique
Qualité de vie / PROMs2
▼
Qualité de vie / PROMs2
▼- Impact of Axial Spondyloarthritis on Quality of Life: Results From the European Map of Axial Spondyloarthritis (EMAS) Study in France
The Journal of rheumatology · 2022 · Letter
Kedra J, Claudepierre P, Flipo RM, Garrido-Cumbrera M, et al.
📚 2 cit. - Fragility fractures in France: epidemiology, characteristics and quality of life (the EPIFRACT study)
Archives of osteoporosis · 2020 · Journal Article
Cortet B, Chauvin P, Feron JM, Grange L, et al.
📚 20 cit.🎯 RCR 1.62🔬→🩺 Translationnel
Arthrose1
▼
Arthrose1
▼- [Vivre avec une arthrose]
La Revue du praticien · 2022 · Journal Article
Grange L
Économie santé1
▼
Économie santé1
▼- The burden of osteoarthritis: development and validation of a new assessment tool (BONe'S)
Current medical research and opinion · 2014 · Journal Article
Rannou F, Bertin P, Grange L, Branchoux S, et al.
📚 6 cit.
Pharmacovigilance1
▼
Pharmacovigilance1
▼- Efficacy and safety of a millimetre wave medical device for pain neuromodulation in peripheral OA: a crossover randomized trial
Rheumatology (Oxford, England) · 2026 · Journal Article
Maindet C, Giai J, Leroy C, Proust M, et al.
📚 1 cit.🩺 Clinique
Sjögren1
▼
Sjögren1
▼- TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review
Autoimmunity reviews · 2022 · Journal Article
Grange L, Chalayer E, Boutboul D, Paul S, et al.
📚 19 cit.🎯 RCR 1.97
Vraie vie / RWE1
▼
Vraie vie / RWE1
▼- Real-world care for individuals aged over fifty with fractures in France: Evidence for a wide care gap-The EPIFRACT Study
Joint bone spine · 2020 · Journal Article
Briot K, Grange L, Cortet B, Feron JM, et al.
📚 5 cit.🔬→🩺 Translationnel
Datasets & protocoles partagés
Amplitude of the thermal hyperhemia in systemic sclerosis (SSc) and rheumatoid arthritis
Image2011figshare<b>Copyright information:</b>Taken from "Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon"Arthritis Research & Therapy 2005;7(5):R1103-R1112.Published online 19 Jul 2005PMCID:PMC1257434.Copyr
Thermal hypermemia in Raynaud's phenomenon (RP), limited and diffuse cutaneous systemic sclerosis (lcSSc and dcSSc)
Image2011figshare<b>Copyright information:</b>Taken from "Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon"Arthritis Research & Therapy 2005;7(5):R1103-R1112.Published online 19 Jul 2005PMCID:PMC1257434.Copyr
Thermal hypermemia in Raynaud's phenomenon (RP), limited and diffuse cutaneous systemic sclerosis (lcSSc and dcSSc)
Image2011figshare<b>Copyright information:</b>Taken from "Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon"Arthritis Research & Therapy 2005;7(5):R1103-R1112.Published online 19 Jul 2005PMCID:PMC1257434.Copyr
Amplitude of the thermal hyperhemia in systemic sclerosis (SSc) and rheumatoid arthritis
Image2011figshare<b>Copyright information:</b>Taken from "Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon"Arthritis Research & Therapy 2005;7(5):R1103-R1112.Published online 19 Jul 2005PMCID:PMC1257434.Copyr
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
