Docteur Marion ARNAUD
2 publis sur 5 ans↘
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
16
h articles cités ≥ h fois chacun. Un h de 16 = 16 publications avec 16+ citations.
Citations
1 568
Publications
56
i10-index
19
Thématiques principales
- CAR-T cell therapy research ×28
- Immunotherapy and Immune Responses ×24
- Cancer Immunotherapy and Biomarkers ×19
- Monoclonal and Polyclonal Antibodies Research ×9
- vaccines and immunoinformatics approaches ×8
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
[Se] Protéger face aux incertitudes de l'avenir
2024Thèse
Aux origines des fonds de pension à la française, Préfon-Retraite
2017ArticleRevue Risques - Les cahiers de l'assurance
Microtubule-driven nuclear rotations promote meiotic chromosome dynamics
2015ArticleNature Cell Biology
Introduction à "La représentation : enjeux littéraires, artistiques et philosophiques, de l’Antiquité au XIXe siècle
2012ArticleCamenae
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Localisation
Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.
Lieu de consultation
CLINIQUE LE TINAILLER
19 RUE DES LOMBARDS, 71870 Hurigny
☎ 0385202122Hospitalier© OpenStreetMap
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
Journal of immunology (Baltimore, Md. : 1950) · 1999
📚 368 citations🎯 RCR 8.45Top 3% NIH - 2PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Nature · 2024
Lire l'abstract Crossref ↓
AbstractExpansion of antigen-experienced CD8+ T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer1. Interleukin-2 (IL-2) acts as a key regulator of CD8+ cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability2,3. Therefore, it is essential to comprehend mechanistic barriers to IL-2 sensing in the tumour microenvironment to implement strategies to reinvigorate IL-2 responsiveness and T cell antitumour responses. Here we report that prostaglandin E2 (PGE2), a known negative regulator of immune response in the tumour microenvironment4,5, is present at high concentrations in tumour tissue from patients and leads to impaired IL-2 sensing in human CD8+ TILs via the PGE2 receptors EP2 and EP4. Mechanistically, PGE2 inhibits IL-2 sensing in TILs by downregulating the IL-2Rγc chain, resulting in defective assembly of IL-2Rβ–IL2Rγc membrane dimers. This results in impaired IL-2–mTOR adaptation and PGC1α transcriptional repression, causing oxidative stress and ferroptotic cell death in tumour-reactive TILs. Inhibition of PGE2 signalling to EP2 and EP4 during TIL expansion for ACT resulted in increased IL-2 sensing, leading to enhanced proliferation of tumour-reactive TILs and enhanced tumour control once the cells were transferred in vivo. Our study reveals fundamental features that underlie impairment of human TILs mediated by PGE2 in the tumour microenvironment. These findings have therapeutic implications for cancer immunotherapy and cell therapy, and enable the development of targeted strategies to enhance IL-2 sensing and amplify the IL-2 response in TILs, thereby promoting the expansion of effector T cells with enhanced therapeutic potential.
- 3Sensitive identification of neoantigens and cognate TCRs in human solid tumors
Nature biotechnology · 2022
Lire l'abstract Crossref ↓
AbstractThe identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal40
▼
Transversal40
▼- Highly efficient gene knockout in tumor-infiltrating lymphocytes by adenine base editing
Molecular therapy. Oncology · 2025 · Journal Article
Hafezi M, Genolet R, Hadadi L, Chap BS, et al.
📚 2 cit. - A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
Nature biotechnology · 2025 · Journal Article
Huber F, Arnaud M, Stevenson BJ, Michaux J, et al.
📚 62 cit.🎯 RCR 21.75🔬→🩺 Translationnel - Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
Nature biotechnology · 2025 · Journal Article
Pétremand R, Chiffelle J, Bobisse S, Perez MAS, et al.
📚 22 cit.🎯 RCR 6.96 - Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma
Immunity · 2024 · Journal Article
Chiffelle J, Barras D, Pétremand R, Orcurto A, et al.
📚 35 cit.🎯 RCR 4.07 - Predicting Antigen-Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024 · Journal Article
Perez MAS, Chiffelle J, Bobisse S, Mayol-Rullan F, et al.
📚 7 cit. - PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Nature · 2024 · Journal Article
Morotti M, Grimm AJ, Hope HC, Arnaud M, et al.
📚 156 cit.🎯 RCR 20.18🔬→🩺 Translationnel - [Adapting technical care to EBH patients]
Soins; la revue de reference infirmiere · 2023 · English Abstract
Arnaud M, Leloup M
- [Care of newborns and infants with epidermolysis bullosa]
Soins; la revue de reference infirmiere · 2023 · English Abstract
Arnaud M, Leloup M
- Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
Nature communications · 2023 · Journal Article
Schmidt J, Chiffelle J, Perez MAS, Magnin M, et al.
📚 53 cit.🎯 RCR 4.05🔬→🩺 Translationnel - TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs
Cell reports methods · 2023 · Journal Article
Genolet R, Bobisse S, Chiffelle J, Arnaud M, et al.
📚 42 cit.🎯 RCR 3.11🔬→🩺 Translationnel - Towards next-generation TIL therapy: TILs enriched in neoepitope-specific T cells
Clinical and translational medicine · 2023 · Journal Article
Arnaud M, Coukos G, Harari A
📚 11 cit. - Sensitive identification of neoantigens and cognate TCRs in human solid tumors
Nature biotechnology · 2022 · Journal Article
Arnaud M, Chiffelle J, Genolet R, Navarro Rodrigo B, et al.
📚 78 cit.🎯 RCR 4.77🔬→🩺 Translationnel - The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients
Frontiers in immunology · 2021 · Journal Article
Arnaud M, Bobisse S, Chiffelle J, Harari A
📚 10 cit. - Biotechnologies to tackle the challenge of neoantigen identification
Current opinion in biotechnology · 2020 · Journal Article
Arnaud M, Duchamp M, Bobisse S, Renaud P, et al.
📚 25 cit. - Serum amyloid A as a marker of disease activity in Giant cell arteritis
Autoimmunity reviews · 2020 · Letter
Dartevel A, Toussaint B, Trocme C, Arnaud M, et al.
📚 11 cit. - High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells
Clinical cancer research : an official journal of the American Association for Cancer Research · 2019 · Journal Article
Costa-Nunes C, Cachot A, Bobisse S, Arnaud M, et al.
📚 13 cit. - Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights
Molecular metabolism · 2018 · Journal Article
Heeley N, Kirwan P, Darwish T, Arnaud M, et al.
📚 16 cit.🔬→🩺 Translationnel - [Temporomandibular joint arthropathy in situ steroid injection]
Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale · 2016 · Case Reports
Gagé J, Gallucci A, Arnaud M, Chossegros C, et al.
📚 3 cit. - Microtubule-driven nuclear rotations promote meiotic chromosome dynamics
Nature cell biology · 2015 · Journal Article
Christophorou N, Rubin T, Bonnet I, Piolot T, et al.
📚 60 cit.🎯 RCR 1.57 - Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis
Arthritis and rheumatism · 2002 · Comparative Study
Vincent C, Nogueira L, Sebbag M, Chapuy-Regaud S, et al.
📚 75 cit.🎯 RCR 1.92 - Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified or deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis
Annals of the rheumatic diseases · 2001 · Comparative Study
Nogueira L, Sebbag M, Vincent C, Arnaud M, et al.
📚 41 cit.🎯 RCR 1.01 - [A case of cervical calcinosis]
La Revue de medecine interne · 2000 · Case Reports
Denes E, Gissot V, Arnaud M, Pascaud JL, et al.
📚 2 cit. - The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
Journal of immunology (Baltimore, Md. : 1950) · 1999 · Journal Article
Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, et al.
📚 368 cit.🎯 RCR 8.45🔬→🩺 Translationnel - A prospective study of pulmonary symptoms in 188 patients with rheumatoid arthritis
Revue du rhumatisme (English ed.) · 1997 · Comment
Treves R, Pugnere N, Bonnet C, Bertin P, et al.
📚 3 cit. - Airway obstruction and rheumatoid arthritis
The European respiratory journal · 1997 · Comparative Study
Vergnenègre A, Pugnere N, Antonini MT, Arnaud M, et al.
📚 70 cit.🎯 RCR 2.83🔬→🩺 Translationnel - [The risk/benefit ratio of low-dose cyclosporin in the treatment of severe rheumatoid arthritis]
Revue du rhumatisme (Ed. francaise : 1993) · 1994 · Clinical Trial
Flipo RM, Bertin P, Combe B, Reigneau O, et al.
🩺 Clinique - Idiopathic retroperitoneal fibrosis with systemic manifestations
The Journal of rheumatology · 1994 · Case Reports
Bonnet C, Arnaud M, Bertin P, Treves R, et al.
📚 15 cit. - Captopril-induced lupus
Clinical and experimental rheumatology · 1993 · Case Reports
Bertin P, Kamdem J, Bonnet C, Arnaud M, et al.
📚 8 cit. - [Still's disease revealed by a retropharyngeal pseudo-abscess]
Presse medicale (Paris, France : 1983) · 1993 · Case Reports
Remy M, Bonnet C, Riche A, Henaux M, et al.
📚 1 cit. - Breast cancer with systemic manifestations mimicking Still's disease
The Journal of rheumatology · 1993 · Case Reports
Rogues AM, Vidal E, Boudinet F, Loustaud V, et al.
📚 29 cit.🎯 RCR 1.57 - [Joint chondrocalcinosis--Bartter's syndrome: a rare association]
Annales de medecine interne · 1993 · Case Reports
Rémy M, Bonnet C, Castellarin M, Arnaud M, et al.
📚 5 cit. - [Acute leukosis after immunosuppressive treatment in rheumatoid polyarthritis]
Revue du rhumatisme et des maladies osteo-articulaires · 1990 · Case Reports
Trèves R, Kabta H, Bonnet C, Arnaud M, et al.
- Infectious arthritis caused by Propionibacterium acnes: a new case
Annals of the rheumatic diseases · 1990 · Case Reports
Bertin P, Treves R, Arnaud M, Traore A, et al.
📚 6 cit. - [Reactional ureaplasma urealyticum arthritis]
Revue du rhumatisme et des maladies osteo-articulaires · 1988 · Case Reports
Archambeaud-Mouveroux F, Trèves R, Arnaud M, Desproges-Gotteron R
📚 3 cit. - Dapsone and rheumatoid vasculitis leg ulcerations
Journal of the American Academy of Dermatology · 1988 · Case Reports
Bernard P, Arnaud M, Treves R, Bonnetblanc JM
📚 15 cit.🔬→🩺 Translationnel - [Osteoporosis after extended and prolonged application of a dermocorticoid]
Therapie · 1987 · Case Reports
Trèves R, Leboutet MJ, Archambaud-Mouveroux F, Bernard P, et al.
- [Cauda equina syndromes in ankylosing spondyloarthritis, detected urologically]
Revue du rhumatisme et des maladies osteo-articulaires · 1987 · Case Reports
Labrousse C, Dudognon P, Arnaud M, Salle JY, et al.
📚 3 cit. - [Neuropathy of the chin as an early sign of acute lymphoblastic leukemia simulating lupus]
Revue du rhumatisme et des maladies osteo-articulaires · 1986 · Letter
Trèves R, Arnaud M, Archambaud-Mouveroux F, Bitaudeau P, et al.
📚 1 cit. - [Dapsone in the treatment of rheumatoid polyarthritis. Double-blind study (11 cases) and open study (7 cases)]
Revue du rhumatisme et des maladies osteo-articulaires · 1985 · Clinical Trial
Trèves R, Jacob P, Arnaud M, Tabaraud F, et al.
📚 1 cit.🩺 Clinique - [Arthritis caused by Yersinia enterocolitica with the presence of intra-articular germs]
Revue du rhumatisme et des maladies osteo-articulaires · 1985 · Case Reports
Treves R, Jacob P, Arnaud M, Papapietro PM, et al.
📚 5 cit.
Revue générale4
▼
Revue générale4
▼- [The image of intravertebral somatic gaseous dissection. Report of 9 cases one of which has a triple localization and review of the literature]
Revue du rhumatisme et des maladies osteo-articulaires · 1990 · Case Reports
Bonnet C, Rochet N, Martchenko A, Arnaud M, et al.
📚 8 cit. - [Stress fractures during treatment of osteoporosis with sodium fluoride. Apropos of a case and a critical review of the literature]
Revue du rhumatisme et des maladies osteo-articulaires · 1990 · Case Reports
Bertin P, Clement S, Arnaud M, Treves R, et al.
📚 6 cit.🔬→🩺 Translationnel - [Sulfasalazine or salazosulfapyridine in the treatment of rheumatoid polyarthritis. An open study of 46 patients. Review of the literature]
Revue du rhumatisme et des maladies osteo-articulaires · 1988 · Clinical Trial
Trèves R, Morvan C, Bitaudeau P, Clément S, et al.
📚 5 cit.🩺 Clinique - [Peri-ungual capillaroscopy in rheumatoid polyarthritis. Critical study of a series of 52 cases and review of the literature]
Revue du rhumatisme et des maladies osteo-articulaires · 1987 · Journal Article
Bernard P, Arnaud M, Tabaraud F, Archambeaud-Mouveroux F, et al.
📚 3 cit.
Sjögren2
▼
Sjögren2
▼- Treatment of non-systemic Sjögren's syndrome: Potential prevention of systematization with immunosuppressant agent/biotherapy
Journal of translational autoimmunity · 2024 · Journal Article
Belbézier A, Nguyen TTT, Arnaud M, Ducotterd B, et al.
📚 4 cit. - [Gougerot-Sjögren syndrome following minimal glomerular involvement]
Revue du rhumatisme et des maladies osteo-articulaires · 1991 · Case Reports
Bonnet C, Martchenko A, Bertin P, Arnaud M, et al.
📚 1 cit.
Épidémiologie & registres1
▼
Épidémiologie & registres1
▼- Zoledronic Acid Contraindications Prevalence among Hip-Fractured Patients Aged 75 Years or Over Hospitalized in an Orthogeriatric Unit
Gerontology · 2022 · Journal Article
Jalbert R, Blain H, Boudissa M, Bioteau C, et al.
📚 3 cit.
IA en rhumatologie1
▼
IA en rhumatologie1
▼- Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction
Immunity · 2023 · Journal Article
Müller M, Huber F, Arnaud M, Kraemer AI, et al.
📚 72 cit.🎯 RCR 6.10
Pédiatrie1
▼
Pédiatrie1
▼- Adolescent osteoporosis disclosing familial osteopenia
Clinical rheumatology · 1992 · Case Reports
Treves R, Harang H, Bertin P, Bonnet C, et al.
📚 3 cit.
Sclérodermie1
▼
Sclérodermie1
▼- [Unusual calcifications in scleroderma. Apropos of a case]
Revue du rhumatisme et des maladies osteo-articulaires · 1988 · Case Reports
Arnaud M, Trèves R, Desproges-Gotteron R, Arnaud JP, et al.
📚 1 cit.
Datasets & protocoles partagés
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
Dataset2024ZenodoSingle-cell RNA (scRNA) and single-cell TCR (scTCR)-sequencing data data for patients number 11, 12 and 14 from the article " Identification of clinically relevant T-cell receptors for personlized T-cell therapy". Each
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
Dataset2024ZenodoSingle-cell RNA (scRNA) and single-cell TCR (scTCR)-sequencing data data for patients number 11, 12 and 14 from the article " Identification of clinically relevant T-cell receptors for personlized T-cell therapy". Each
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).