Docteur Sophie HECQUET

Thèses universitaires

• Inflammation et perméabilité intestinales et translocation bactérienne en cas d'arthrite : études précliniques et cliniques

  2024

  Intestinal inflammation and permeability and bacterial translocation in arthritis : preclinical and clinical studies

  Médecine, cancérologie, génétique, hématologie, immunologie🎓 Bourgogne Franche-Comté

  Direction : Céline Demougeot, Frank Verhoeven

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Bacterial translocation and intestinal permeability in early axial spondyloarthritis association with 5-year outcomes: insights from the DESIR cohort

  2026

  ArticleRheumatology

• Hand function impairment in Systemic Sclerosis: determinants through investigations of clinical, radiographic and ultrasonographic features

  2025

  ArticleSeminars in Arthritis and Rheumatism

• Naproxen and prednisolone reduced intestinal alteration and permeability and bacterial translocation in rat adjuvant-induced arthritis

  2025

  ArticleInflammopharmacology

• Recommendations of the French Society of Rheumatology for the management in current practice of patients with polymyalgia rheumatica

  2024

  ArticleJoint Bone Spine

• Recommendations for assessing the risk of cardiovascular disease and venous thromboembolism before the initiation of targeted therapies for chronic inflammatory rheumatic diseases

  2023

  ArticleJoint Bone Spine

• Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

  2023

  ArticleArthritis Research & Therapy

• Erratum to ``2022 French Society for Rheumatology (SFR) Recommendations on the Everyday Management of Patients with Spondyloarthritis, Including Psoriatic Arthritis'' [Joint Bone Spine 2022;89:105344]

  2022

  ArticleJoint Bone Spine

• 2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis

  2021

  ArticleJoint Bone Spine

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

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Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis

  Joint bone spine · 2022

  📚 47 citations🎯 RCR 5.37Top 7% NIH🔓 Open Access
• 2

  Characteristics of patients with difficult-to-treat rheumatoid arthritis in a French single-centre hospital

  Rheumatology (Oxford, England) · 2023

  📚 26 citations🎯 RCR 4.24Top 10% NIH

  Lire l'abstract Crossref ↓

  Abstract Objectives To compare the features of difficult-to-treat rheumatoid arthritis (D2TRA) patients using two different definitions according to the previous failure of targeted therapies. Methods We stratified consecutive RA patients treated at Cochin Hospital into two groups, a D2TRA group and a non-D2TRA group, according to two definitions of D2TRA. Both definitions defined D2TRA as RAs failing at least two targeted therapies, with a different mechanism of action for the EULAR-D2TRA definition or without prejudging the mechanism of action and for the Alternative D2TRA definition. Results We included 320 consecutive RA patients. We identified 76 EULAR-D2TRA and 244 non-DTRA patients, and 120 Alternative D2TRA and 200 non-DTRA patients. Compared with non-D2TRA, D2TRA patients from both definitions were more likely to have lower socioeconomic level, positive rheumatoid factor, interstitial lung disease, higher DAS28-CRP and were more likely to respond to rituximab and Janus kinase inhibitors. Although EULAR and Alternative D2TRA patients displayed similar clinical and biological features, they were characterized by different therapeutic profiles. We observed fewer patients receiving methotrexate in the Alternative D2TRA group (53% vs 64%, P = 0.046). Patients with Alternative D2TRA not fulfilling the EULAR definition (n = 44) had all received two successive first-line TNF inhibitors, a monoclonal antibody and a soluble receptor, and were comparable to EULAR-D2TRA patients with regards to all other characteristics. Conclusion Low socioeconomic status, diabetes, interstitial lung disease and absence of combination with methotrexate allow identification of D2TRA. In addition, the inclusion as ‘early-D2TRA’ of patients failing two TNF inhibitors in the EULAR definition of D2TRA would facilitate the rapid identification of D2TRA patients.

• 3

  Erratum to "2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis" [Joint Bone Spine 2022;89:105344]

  Joint bone spine · 2022

  📚 26 citations🎯 RCR 2.78Top 18% NIH

Publications scientifiques (24) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

  Collection2023figshare

  Abstract Background Intestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear and their c

• Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

  Collection2023figshare

  Abstract Background Intestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear and their c

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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