Docteur GILLES HAYEM
✨ Profil synthétique
IA · 04/05/2026Le Docteur GILLES HAYEM est un rhumatologue hospitalier à Paris, rattaché au Centre de compétence FAI²R. Ses recherches portent principalement sur les maladies rhumatismales, notamment la polyarthrite rhumatoïde et le lupus érythémateux systémique. Avec un h-index de 47 et plus de 200 publications, il démontre une activité de recherche significative. Il a également dirigé une thèse en médecine.
Expertises présumées
- Rhumatologie
- Polyarthrite rhumatoïde
- Lupus érythémateux systémique
- Spondylarthrite
- Ostéomyélite
- Troubles des glandes salivaires
- Pathologies osseuses
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Direction de thèses
🎓 1 thèse dirigéeSource theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
49
h articles cités ≥ h fois chacun. Un h de 49 = 49 publications avec 49+ citations.
Citations
8 772
Publications
206
i10-index
90
Thématiques principales
- Rheumatoid Arthritis Research and Therapies ×32
- Systemic Lupus Erythematosus Research ×32
- Osteomyelitis and Bone Disorders Research ×22
- Salivary Gland Disorders and Functions ×21
- Spondyloarthritis Studies and Treatments ×19
Affiliations FR : Hôpital Paris Saint-Joseph
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis
2025ArticleFree Radical Biology and Medicine
Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Study
2025ArticleJournal of Medical Imaging
Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis.
2024ArticleRheumatology
The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites
2024ArticleInternational Immunopharmacology
Survey of adolescents’ needs and parents’ views on sexual health in juvenile idiopathic arthritis
2023ArticlePediatric Rheumatology
Influenza‐like illness in individuals treated with immunosuppressants, biologics, and/or systemic corticosteroids for autoimmune or chronic inflammatory disease: A crowdsourced cohort study, France, 2017–2018
2023ArticleInfluenza and Other Respiratory Viruses
Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
2021ArticleThe Lancet Rheumatology
Epidemiology of cutaneous involvement in Sjögren syndrome: Data from three French pSS populations (TEARS, ASSESS, diapSS)
2021ArticleJoint Bone Spine
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
GH PARIS SITE SAINT JOSEPH
185 Rue RAYMOND LOSSERAND, 75674 Paris 14e Arrondissement
☎ 0144123500Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Anakinra for severe forms of COVID-19: a cohort study
The Lancet. Rheumatology · 2020
- 2Treatment of primary Sjögren syndrome with rituximab: a randomized trial
Annals of internal medicine · 2014
📚 307 citations🎯 RCR 11.40Top 2% NIH🩺 Clinique - 3Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial
JAMA · 2014
📚 230 citations🎯 RCR 9.12Top 3% NIH🩺 Clinique
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal26
▼
Transversal26
▼- Phenotypic clustering in adult SAPHO syndrome: A multicenter retrospective study of 102 patients
Journal of the American Academy of Dermatology · 2026 · Journal Article
Delmotte A, Mulier G, Fogel O, Bessis D, et al.
- Self-supervision enhances instance-based multiple instance learning methods in digital pathology: a benchmark study
Journal of medical imaging (Bellingham, Wash.) · 2025 · Journal Article
Mammadov A, Le Folgoc L, Adam J, Buronfosse A, et al.
📚 1 cit. - The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis
Free radical biology & medicine · 2025 · Journal Article
Gardette A, Marzaioli V, Bedouhene S, Hayem G, et al.
📚 5 cit.🎯 RCR 2.19 - The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites
International immunopharmacology · 2024 · Journal Article
Boussetta T, Raad H, Bedouhene S, Arabi Derkawi R, et al.
📚 8 cit.🎯 RCR 1.95 - SEVERE CORONAVIRUS DISEASE 2019: FROM PATHOGENESIS TO THERAPY
Shock (Augusta, Ga.) · 2023 · Journal Article
Cavaillon JM, Artigas A, Barratt-Due A, Giamarellos-Bourboulis EJ, et al.
📚 2 cit. - What is the impact on work of osteoporotic fractures in active patients? A retrospective fracture-liaison-service study-Optiwork 1
Archives of osteoporosis · 2022 · Journal Article
Portier A, Tissier M, Villoutreix C, Monrose N, et al.
📚 2 cit. - Atypical splice-site mutations causing VEXAS syndrome
Rheumatology (Oxford, England) · 2021 · Case Reports
Templé M, Duroyon E, Croizier C, Rossignol J, et al.
📚 57 cit.🎯 RCR 3.44 - The time to offer treatments for COVID-19
Expert opinion on investigational drugs · 2021 · Journal Article
Ngo BT, Marik P, Kory P, Shapiro L, et al.
📚 24 cit.🎯 RCR 1.30 - The Importance of Understanding the Stages of COVID-19 in Treatment and Trials
AIDS reviews · 2021 · Journal Article
Griffin DO, Brennan-Rieder D, Ngo B, Kory P, et al.
📚 61 cit.🎯 RCR 3.23🔬→🩺 Translationnel - Anakinra for severe forms of COVID-19 - Authors' reply
The Lancet. Rheumatology · 2020 · Journal Article
Hayem G, Huet T, Jouveshomme S, Beaussier H, et al.
- Interleukin-1 Inhibitors and Dacryoadenitis in Adult-Onset Still Disease
Annals of internal medicine · 2018 · Case Reports
Breillat P, Tourte M, Romero P, Hayem G, et al.
📚 3 cit. - SAPHO, autophagy, IL-1, FoxO1, and Propionibacterium (Cutibacterium) acnes
Joint bone spine · 2018 · Journal Article
Berthelot JM, Corvec S, Hayem G
📚 48 cit.🎯 RCR 3.20 - Granulomatosis with polyangiitis according to geographic origin and ethnicity: clinical-biological presentation and outcome in a French population
Rheumatology (Oxford, England) · 2017 · Journal Article
Terrier B, Dechartres A, Deligny C, Godmer P, et al.
📚 18 cit.🔬→🩺 Translationnel - Periodontal disease in patients with rheumatoid arthritis in Sub-Saharan Africa: A case-control study
Joint bone spine · 2017 · Letter
Ouédraogo DD, Tiendrébéogo J, Guiguimdé PL, Nikiéma PI, et al.
📚 8 cit. - Rheumatoid neutrophilic dermatitis
Joint bone spine · 2016 · Case Reports
André R, de Maleissye MF, Costantino F, Sohier P, et al.
📚 5 cit. - Intravenous Immunoglobulin as an Immunomodulating Agent in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides: A French Nationwide Study of Ninety-Two Patients
Arthritis & rheumatology (Hoboken, N.J.) · 2016 · Journal Article
Crickx E, Machelart I, Lazaro E, Kahn JE, et al.
📚 48 cit.🎯 RCR 2.29🔬→🩺 Translationnel - Granulomatosis with polyangiitis: endoscopic management of tracheobronchial stenosis: results from a multicentre experience
Rheumatology (Oxford, England) · 2015 · Journal Article
Terrier B, Dechartres A, Girard C, Jouneau S, et al.
📚 50 cit.🎯 RCR 2.54🔬→🩺 Translationnel - Reversal of Arthritis by Human Monomeric IgA Through the Receptor-Mediated SH2 Domain-Containing Phosphatase 1 Inhibitory Pathway
Arthritis & rheumatology (Hoboken, N.J.) · 2015 · Journal Article
Rossato E, Ben Mkaddem S, Kanamaru Y, Hurtado-Nedelec M, et al.
📚 47 cit.🎯 RCR 1.54 - Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis
The Journal of clinical investigation · 2014 · Journal Article
Ben Mkaddem S, Hayem G, Jönsson F, Rossato E, et al.
📚 81 cit.🎯 RCR 2.24 - Hidradenitis suppurativa associated with spondyloarthritis -- results from a multicenter national prospective study
The Journal of rheumatology · 2014 · Journal Article
Richette P, Molto A, Viguier M, Dawidowicz K, et al.
📚 90 cit.🎯 RCR 4.18🔬→🩺 Translationnel - The immune response in SAPHO syndrome: deficiency, hyper- responsiveness, or both?
Current rheumatology reviews · 2013 · Journal Article
Hayem G, Hurtado-Nedelec M, Chollet-Martin S
📚 2 cit. - Still's disease and the mitochondrion: the other face of an old friend?
Medical hypotheses · 2012 · Journal Article
Hayem F, Hayem G
📚 5 cit. - Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes
The American journal of pathology · 2012 · Journal Article
Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, et al.
📚 52 cit.🎯 RCR 1.54🔬→🩺 Translationnel - Melorheostosis associated with peripheral form spondyloarthropathy: new image with 18-fluoride positron emission tomoscintigraphy coupled to computed tomography
Open access rheumatology : research and reviews · 2012 · Case Reports
Hassani H, Slama J, Hayem G, Ben Ali K, et al.
📚 1 cit. - High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis
The Journal of rheumatology · 2011 · Journal Article
Aubart F, Crestani B, Nicaise-Roland P, Tubach F, et al.
📚 84 cit.🎯 RCR 2.78🔬→🩺 Translationnel - The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils
Blood · 2010 · Journal Article
Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, et al.
📚 84 cit.🎯 RCR 1.94🔬→🩺 Translationnel
Sjögren9
▼
Sjögren9
▼- Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis
Rheumatology (Oxford, England) · 2025 · Journal Article
Astouati Q, Machet T, Houssais C, Noury JB, et al.
📚 6 cit.🎯 RCR 2.59 - Epidemiology of cutaneous involvement in Sjögren syndrome: Data from three French pSS populations (TEARS, ASSESS, diapSS)
Joint bone spine · 2021 · Journal Article
Villon C, Orgeolet L, Roguedas AM, Misery L, et al.
📚 11 cit.🎯 RCR 1.10🩺 Clinique - Severe Health-Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial
Arthritis care & research · 2017 · Clinical Trial
Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, et al.
📚 69 cit.🎯 RCR 3.90🩺 Clinique - Which and How Many Patients Should Be Included in Randomised Controlled Trials to Demonstrate the Efficacy of Biologics in Primary Sjögren's Syndrome?
PloS one · 2015 · Journal Article
Devauchelle-Pensec V, Gottenberg JE, Jousse-Joulin S, Berthelot JM, et al.
📚 18 cit.🔬→🩺 Translationnel - Development of the Sjögren's Syndrome Responder Index, a data-driven composite endpoint for assessing treatment efficacy
Rheumatology (Oxford, England) · 2015 · Journal Article
Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, et al.
📚 47 cit.🎯 RCR 1.97🩺 Clinique - Sjögren's syndrome complicated by interstitial cystitis: A case series and literature review
Joint bone spine · 2015 · Case Reports
Darrieutort-Laffite C, André V, Hayem G, Saraux A, et al.
📚 16 cit.🔬→🩺 Translationnel - Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial
JAMA · 2014 · Journal Article
Gottenberg JE, Ravaud P, Puéchal X, Le Guern V, et al.
📚 230 cit.🎯 RCR 9.12🩺 Clinique - Treatment of primary Sjögren syndrome with rituximab: a randomized trial
Annals of internal medicine · 2014 · Journal Article
Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, et al.
📚 307 cit.🎯 RCR 11.40🩺 Clinique - European League Against Rheumatism Sjögren's Syndrome Disease Activity Index and European League Against Rheumatism Sjögren's Syndrome Patient-Reported Index: a complete picture of primary Sjögren's syndrome patients
Arthritis care & research · 2013 · Comparative Study
Seror R, Gottenberg JE, Devauchelle-Pensec V, Dubost JJ, et al.
📚 76 cit.🎯 RCR 3.32🔬→🩺 Translationnel
Épidémiologie & registres4
▼
Épidémiologie & registres4
▼- Influenza-like illness in individuals treated with immunosuppressants, biologics, and/or systemic corticosteroids for autoimmune or chronic inflammatory disease: A crowdsourced cohort study, France, 2017-2018
Influenza and other respiratory viruses · 2023 · Journal Article
Greffe S, Guerrisi C, Souty C, Vilcu AM, et al.
📚 3 cit. - Anakinra for severe forms of COVID-19: a cohort study
The Lancet. Rheumatology · 2020 · Journal Article
Huet T, Beaussier H, Voisin O, Jouveshomme S, et al.
📚 488 cit.🎯 RCR 23.99🔬→🩺 Translationnel - Prevalence of autoantibodies in SAPHO syndrome: a single-center study of 90 patients
The Journal of rheumatology · 2010 · Journal Article
Grosjean C, Hurtado-Nedelec M, Nicaise-Roland P, Ferreyra-Dillon R, et al.
📚 40 cit.🎯 RCR 1.59 - Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study
The Journal of rheumatology · 2010 · Journal Article
Meyer O, De Chaisemartin L, Nicaise-Roland P, Cabane J, et al.
📚 45 cit.🎯 RCR 1.57🔬→🩺 Translationnel
Anti-TNF3
▼
Anti-TNF3
▼- Cytomegalovirus subacute thyroiditis in a patient treated by infliximab for psoriatic arthritis
Joint bone spine · 2016 · Letter
André R, Opris A, Costantino F, Hayem G, et al.
📚 5 cit. - Body mass index influences the response to infliximab in ankylosing spondylitis
Arthritis research & therapy · 2012 · Journal Article
Ottaviani S, Allanore Y, Tubach F, Forien M, et al.
📚 84 cit.🎯 RCR 2.94🔬→🩺 Translationnel - Prospective cohort study of effects of infliximab on rheumatoid factor, anti-cyclic citrullinated peptide antibodies and antinuclear antibodies in patients with long-standing rheumatoid arthritis
Joint bone spine · 2009 · Journal Article
Bruns A, Nicaise-Roland P, Hayem G, Palazzo E, et al.
📚 28 cit.🔬→🩺 Translationnel
Biothérapies non-anti-TNF3
▼
Biothérapies non-anti-TNF3
▼- Management of severe and refractory Mooren's ulcers with rituximab
The British journal of ophthalmology · 2017 · Journal Article
Guindolet D, Reynaud C, Clavel G, Belangé G, et al.
📚 17 cit.🎯 RCR 1.12 - Treatment of primary Sjögren syndrome with rituximab: a randomized trial
Annals of internal medicine · 2014 · Journal Article
Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, et al.
📚 307 cit.🎯 RCR 11.40🩺 Clinique - 25-hydroxyvitamin D status does not affect the clinical rituximab response in rheumatoid arthritis
Joint bone spine · 2014 · Letter
M'Barek RB, Dupré T, Tubach F, Dieudé P, et al.
📚 1 cit.
Revue générale2
▼
Revue générale2
▼- Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
The Lancet. Rheumatology · 2021 · Journal Article
Kyriazopoulou E, Huet T, Cavalli G, Gori A, et al.
📚 133 cit.🎯 RCR 7.57🔬→🩺 Translationnel - Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review
Journal of clinical medicine · 2020 · Journal Article
Trabelsi M, Romand X, Gilson M, Vaillant M, et al.
📚 17 cit.🎯 RCR 1.30
Arthrite juvénile1
▼
Arthrite juvénile1
▼- Survey of adolescents' needs and parents' views on sexual health in juvenile idiopathic arthritis
Pediatric rheumatology online journal · 2023 · Journal Article
Savel C, Chausset A, Berland P, Guiguet-Auclair C, et al.
📚 1 cit.
csDMARDs1
▼
csDMARDs1
▼- Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial
JAMA · 2014 · Journal Article
Gottenberg JE, Ravaud P, Puéchal X, Le Guern V, et al.
📚 230 cit.🎯 RCR 9.12🩺 Clinique
Fièvres auto-inflammatoires1
▼
Fièvres auto-inflammatoires1
▼- Circulating IL-6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID-19
Journal of leukocyte biology · 2022 · Letter
Granger V, Fels A, Huet T, Laplanche JL, et al.
📚 1 cit.
Génétique1
▼
Génétique1
▼- Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes
The Journal of rheumatology · 2010 · Journal Article
Hurtado-Nedelec M, Chollet-Martin S, Chapeton D, Hugot JP, et al.
📚 67 cit.🎯 RCR 2.27
Pharmacovigilance1
▼
Pharmacovigilance1
▼- Epidural steroid injections in the management of low-back pain with radiculopathy: an update of their efficacy and safety
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2012 · Journal Article
Benoist M, Boulu P, Hayem G
📚 59 cit.🎯 RCR 2.68🔬→🩺 Translationnel
Revue / méta-analyse1
▼
Revue / méta-analyse1
▼- Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
The Lancet. Rheumatology · 2021 · Journal Article
Kyriazopoulou E, Huet T, Cavalli G, Gori A, et al.
📚 133 cit.🎯 RCR 7.57🔬→🩺 Translationnel
Datasets & protocoles partagés
Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Study
Preprint2025arXivMultiple Instance Learning (MIL) has emerged as the best solution for Whole Slide Image (WSI) classification. It consists of dividing each slide into patches, which are treated as a bag of instances labeled with a global
The time to offer treatments for COVID-19
Dataset2021Taylor & Francis<b>Background:</b> COVID-19 has several overlapping phases. Treatments to date have focused on the late stage of disease in hospital. Yet, the pandemic is by propagated by the viral phase in out-patients. The current pub
Survey of adolescents’ needs and parents’ views on sexual health in juvenile idiopathic arthritis
Collection2023figshareAbstract Background Although the advent of new therapeutics for juvenile idiopathic arthritis (JIA) patients has considerably lessened the impact of the disease and reduced its sequelae, the outcomes of JIA remain import
Survey of adolescents’ needs and parents’ views on sexual health in juvenile idiopathic arthritis
Collection2023figshareAbstract Background Although the advent of new therapeutics for juvenile idiopathic arthritis (JIA) patients has considerably lessened the impact of the disease and reduced its sequelae, the outcomes of JIA remain import
The time to offer treatments for COVID-19
Dataset2021Taylor & Francis<b>Background:</b> COVID-19 has several overlapping phases. Treatments to date have focused on the late stage of disease in hospital. Yet, the pandemic is by propagated by the viral phase in out-patients. The current pub
The time to offer treatments for COVID-19
Dataset2021Taylor & Francis<b>Background:</b> COVID-19 has several overlapping phases. Treatments to date have focused on the late stage of disease in hospital. Yet, the pandemic is by propagated by the viral phase in out-patients. The current pub
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).