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Rhumatologue

Docteur XAVIER AYRAL

📍 Paris 14e Arrondissement (75)HospitalierRPPS 10000478650
📚 HAL (2)

Diplômes

🎓 DES & spécialité ordinale

  • DES Rhumatologie
  • Rhumatologie (SM)

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

  • GHU APHP CUP SITE COCHIN PORT ROYAL

    27 Rue DU FAUBOURG SAINT JACQUES, 75679 Paris 14e Arrondissement

    ☎ 0158414141Hospitalier

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

  • 1
    Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients

    Osteoarthritis and cartilage · 2005

    📚 464 citations🎯 RCR 12.64Top 2% NIH🔓 Open Access📄 PDF gratuit ↗
  • 2
    Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

    Arthritis and rheumatism · 2002

    📚 237 citations🎯 RCR 6.96Top 5% NIH
    Lire l'abstract Crossref ↓

    AbstractObjectiveThe hallmark of osteoarthritis (OA) is the loss of articular cartilage. This loss arises from an imbalance between cartilage synthesis and cartilage degradation over a variable period of time. The aims of this study were to investigate the rates of these processes in patients with knee OA using two new molecular markers and to investigate whether the combined use of these markers could predict the progression of joint damage evaluated by both radiography and arthroscopy of the joints during a period of 1 year.MethodsSeventy‐five patients with medial knee OA (51 women, 24 men; mean ± SD age 63 ± 8 years, mean ± SD disease duration 4.8 ± 5.2 years) were studied prospectively. At baseline, we measured serum levels of N‐propeptide of type IIA procollagen (PIIANP) and urinary excretion of C‐terminal crosslinking telopeptide of type II collagen (CTX‐II) as markers of type II collagen synthesis and degradation, respectively. Joint space width (JSW) on radiography and medial chondropathy at arthroscopy (assessed using a 100‐mm visual analog scale [VAS]) were measured in all patients at baseline and in 52 patients at 1 year. Progression of joint destruction was defined as a decrease of ≥0.5 mm in JSW on radiography and as increased chondropathy (an increase in the VAS score of >8.0 units) between the baseline and 1‐year evaluations.ResultsAt baseline, compared with 58 healthy age‐ and sex‐matched controls, patients with knee OA had decreased serum levels of PIIANP (20 ng/ml versus 29 ng/ml; P < 0.001) and increased urinary excretion of CTX‐II (618 ng/mmole creatinine [Cr] versus 367 ng/mmole Cr; P < 0.001). The highest discrimination between OA patients and controls was obtained by combining PIIANP and CTX‐II in an uncoupling index (Z score CTX‐II − Z score PIIANP), which yielded a mean Z score of 2.9 (P < 0.0001). Increased baseline values in the uncoupling index were associated with greater progression of joint damage evaluated either by changes in JSW (r = −0.46, P = 0.0016) or by VAS score (r = 0.36, P = 0.014). Patients with both low levels of PIIANP (less than or equal to the mean − 1 SD in controls) and high levels of CTX‐II (greater than or equal to the mean + 1 SD in controls) had an 8‐fold more rapid progression of joint damage than other patients (P = 0.012 and P < 0.0001 as assessed by radiography and arthroscopy, respectively) and had relative risks of progression of 2.9 (95% confidence interval [95% CI] 0.80–11.1) and 9.3 (95% CI 2.2–39) by radiography and arthroscopy, respectively.ConclusionPatients with knee OA are characterized by an uncoupling of type II collagen synthesis and degradation which can be detected by assays for serum PIIANP and urinary CTX‐II. The combination of these two new markers could be useful for identifying knee OA patients at high risk for rapid progression of joint damage.

  • 3
    Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee

    Osteoarthritis and cartilage · 1997

    📚 204 citations🎯 RCR 8.41Top 3% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (50) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal38

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Corticothérapie3

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Essai clinique3

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Revue générale2

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Biothérapies non-anti-TNF1

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csDMARDs1

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Qualité de vie / PROMs1

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Santé mentale / fatigue1

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