Docteur CLEMENCE PICHON

Bibliographie

• Role of stress in the development of rheumatoid arthritis: a case–control study

  2021

  ArticleRheumatology

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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Top publications · les plus citées

• 1

  Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions

  Journal of cellular physiology · 2008

  📚 76 citations🎯 RCR 2.15Top 24% NIH

  Lire l'abstract Crossref ↓

  AbstractFindings from animal studies have suggested that bone remodeling is under beta‐adrenergic control. However, the level of adrenergic inhibition required to achieve the most favorable effects on the skeleton remains unknown. To address this question, we compared the effects of low (0.1 mg/Kg/day), medium (5 mg/Kg/day) or high (20 mg/Kg/day) doses of propranolol given 5 days per week for 10 weeks in ovariectomized (OVX) rats. Characteristics of bone microarchitecture, biomechanical properties and bone turnover were investigated, whilst heart functions were assessed by echocardiography and catheterization of the left ventricle. We first confirmed the expression of Adrβ2R and the absence of Adrβ1R on osteoblasts by PCR and confocal microscopy. We then showed that low dose propranolol prevented OVX induced bone loss by increasing bone formation (+30% of MAR vs. placebo, P = 0.01) and decreasing bone resorption (−52% of osteoclast surface on bone surface vs. placebo, P = 0.01). Consequently, rats receiving 0.1 mg/kg/day propranolol displayed higher stress (+27%), intrinsic energy (+28.7%) and Young's Modulus in compression versus placebo (all, P < 0.05). No significant effects on heart hemodynamic parameters were found in rats receiving this dose. In contrast, medium and high doses of propranolol had a negative effect on heart functions but no significant protective effects on bone mass in ovariectomized rats. These results, consistent with the dominant nature of the high bone mass phenotype and normal heart function of Adrβ2R‐deficient mice, suggest that low doses of β‐blockers may have a therapeutic utility in the treatment of osteoporosis with high selectivity for bone tissues. J. Cell. Physiol. 217: 819–827, 2008. © 2008 Wiley‐Liss, Inc.

• 2

  RNA-based therapy for osteogenesis

  International journal of pharmaceutics · 2019

  📚 27 citations🎯 RCR 1.32🔓 Open Access
• 3

  Using Patient Feedback to Optimize the Design of a Certolizumab Pegol Electromechanical Self-Injection Device: Insights from Human Factors Studies

  Advances in therapy · 2018

  📚 19 citations🎯 RCR 1.07🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (4) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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