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RhumatologueMédecins généralistes et spécialistes⚖️ Libéral activité salarié

Mme Docteur TIFENN LETURCQ

📍 Paris (75)Mixte💶 Secteur 2RPPS 10100526614
📊 Reconnaissance scientifique : 9/100📝 11 articles publiés📚 HAL (3)

Diplômes

🎓 DES & spécialité ordinale

  • DES Rhumatologie
  • Rhumatologie (SM)

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

9

h articles cités ≥ h fois chacun. Un h de 9 = 9 publications avec 9+ citations.

Citations

722

Publications

11

i10-index

8

Thématiques principales

  • Rheumatoid Arthritis Research and Therapies ×4
  • Bone health and treatments ×4
  • Vasculitis and related conditions ×3
  • Spondyloarthritis Studies and Treatments ×3
  • Bone health and osteoporosis research ×2

Affiliations FR : Fondation Ophtalmologique Adolphe de Rothschild

Voir sur OpenAlex ↗

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation des cabinets

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

Tarifs & secteur de conventionnement

🟡 Secteur 2 — Honoraires libresSource CNAM (Annuaire santé Ameli)
💳 Carte VitaleLibéral activité salarié
📊 Comprendre le remboursement

Prendre rendez-vous & contact

🗓 Trouver sur Doctolib📇 Ajouter à mes contacts

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

  • 1
    Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study

    Annals of the rheumatic diseases · 2013

    📚 131 citations🎯 RCR 4.80Top 8% NIH
  • 2
    ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

    Arthritis & rheumatology (Hoboken, N.J.) · 2015

    📚 55 citations🎯 RCR 1.78
    Lire l'abstract Crossref ↓

    ObjectiveSeveral polymorphisms in ERAP1 are strongly associated with susceptibility to spondyloarthritis (SpA). The combination of rs17482078, rs10050860, and rs30187 results in the construction of 3 major haplotypes that are associated with SpA (the “protective” haplotype T/T/C, the “neutral” haplotype C/C/C, and the “susceptibility” haplotype C/C/T). The aim of the present study was to determine whether such haplotypes might affect endoplasmic reticulum aminopeptidase 1 (ERAP‐1) messenger RNA (mRNA) expression, protein level, and/or enzymatic activity in antigen‐presenting cells, a type of cell that is potentially relevant to disease pathogenesis.MethodsMonocyte‐derived dendritic cells (DCs) were generated in 2 cohorts (a discovery cohort and a replication cohort) comprising a total of 23 SpA patients and 44 healthy controls. Lymphoblastoid B cell lines were established from individuals who were homozygous for the risk, the neutral, or the protective ERAP1 haplotype, respectively. In those samples, we investigated the relationship between ERAP1 haplotypes and mRNA expression level. We also used Western blot analysis to measure the relative protein expression of ERAP‐1 and a fluorogenic assay to measure its enzymatic activity.ResultsIn monocyte‐derived DCs, there was a strong association between ERAP1 haplotypes and the ERAP‐1 mRNA expression level, with higher levels in subjects harboring the susceptibility haplotype (P = 0.001 and P = 5.6 × 10−7 in the discovery and replication cohorts, respectively). In lymphoblastoid B cell lines, we observed a significant correlation between haplotype risk score and ERAP1 transcript or protein level (P = 0.003, ρ = 0.92 for both). Enzymatic activity followed a similar trend both in monocyte‐derived DCs and in lymphoblastoid B cell lines.ConclusionThese data provide strong evidence that SpA‐associated ERAP1 polymorphisms affect the level of gene expression in antigen‐presenting cells. How increased production/activity of ERAP‐1 may influence susceptibility to SpA remains to be determined.

  • 3
    Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019

    📚 47 citations🎯 RCR 2.60Top 19% NIH

Publications scientifiques (8) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal4

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Biothérapies non-anti-TNF1

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Génétique1

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IRM ostéo-articulaire1

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Ostéoporose1

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