Docteur JEAN-MICHEL FARRE

• Polyarthrite rhumatoide chez la femme enceinte : a propos de sept cas

  1988

  Doctorant·e : EL-ARBI EL OMARI ALAOUI

  Médecine🎓 Lille 2

Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).

Lieu de consultation

• CHR LILLE

  2 Avenue OSCAR LAMBRET, 59037 Lille

  ☎ 0320445962Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Increased TNF-alpha secretion by alveolar macrophages from patients with rheumatoid arthritis

  The American review of respiratory disease · 1991

  📚 38 citations🎯 RCR 1.34

  Lire l'abstract Crossref ↓

  Abstract Tumor necrosis factor a (TNF) and interleukin-1 (IL-1) production by alveolar macrophages (AM) was evaluated in 17 rheumatoid arthritis (RA) patients without interstitial lung disease (ILD, Group 1) and 14 RA patients with clinical ILD (Group 2) in comparison with 10 control subjects. AM after recovery by bronchoalveolar lavage were selected by adherence, and then supernatants were collected after 3 or 24 h of culture. Results showed no modification of IL-1 synthesis in either group of RA patients. Spontaneous TNF production was significantly increased in Group 2 (2.5 ± 0.5 ng/ml) as well as in Group 1 (2.4 ± 0.4 ng/ml) compared with control subjects (0.43 ± 0.1 ng/ml, p < 0.001). In addition, AM from patients untreated or treated exclusively by nonsteroldal antiinflammatory drugs produced similar levels of TNF, whereas those receiving corticosteroids, second-line drugs (such as sulfasalazine, aurothiomalate, and methotrexate), or the combination of both therapy regimens released significantly less TNF. Interestingly, TNF was not different in both groups, but Group 2 had a markedly increased ratio of local immune complex to albumin in bronchoalveolar lavage fluid (0.47 ± 0.12 versus 0.07 ± 0.02 in Group 1; p < 0.002). TNF thus appears an additional component of RA subclinical alveolitis in RA, but its prognostic value and its precise role in lung damage remain to be determined. Development of ILD requires certainly complex interactions of synergistic factors, possibly including local immune complexes detected in BAL fluids.

• 2

  Subclinical alveolar inflammation in rheumatoid arthritis: superoxide anion, neutrophil chemotactic activity and fibronectin generation by alveolar macrophages

  The European respiratory journal · 1989

  📚 32 citations🎯 RCR 1.64
• 3

  [Clinical and epidemiological study of osteoarthritis of the hand. Based on 500 cases selected from a Health Examination Center]

  Revue du rhumatisme et des maladies osteo-articulaires · 1991

  📚 6 citations

Publications scientifiques (7) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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