Docteur MARINE CLAY

Bibliographie

• Prévalence échographique des synovites et ténosynovites de la main et du pied dans la sclérodermie systémique et corrélation avec les caractéristiques de la maladie dont le handicap de la main

  2020

  ArticleRevue du Rhumatisme

• Rhumatologie interventionnelle : gestes écho-guidés

  2020

  ArticleRevue du Rhumatisme monographies

• Ultrasound prevalence of wrist, hand, ankle and foot synovitis and tenosynovitis in systemic sclerosis, and relationship with disease features and hand disability

  2020

  ArticleJoint Bone Spine

• Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies

  2016

  ArticleAutoimmunity

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

• GROUPE HOSPIT. MUTUALISTE DE GRENOBLE

  8 Rue DOCTEUR CALMETTE, 38028 Grenoble

  ☎ 0476707000Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

  Science translational medicine · 2022

  📚 127 citations🎯 RCR 10.92Top 2% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that occurs with disease. However, the connection between the mucosa and systemic autoimmunity in RA remains unclear. Using dual immunoglobulin A (IgA) and IgG family plasmablast–derived monoclonal autoantibodies obtained from peripheral blood of individuals at risk for RA, we identified cross-reactivity between RA-relevant autoantigens and bacterial taxa in the closely related families Lachnospiraceae and Ruminococcaceae . After generating bacterial isolates within the Lachnospiraceae/Ruminococcaceae genus Subdoligranulum from the feces of an individual, we confirmed monoclonal antibody binding and CD4 + T cell activation in individuals with RA compared to control individuals. In addition, when Subdoligranulum isolate 7 but not isolate 1 colonized germ-free mice, it stimulated T H 17 cell expansion, serum RA–relevant IgG autoantibodies, and joint swelling reminiscent of early RA, with histopathology characterized by antibody deposition and complement activation. Systemic immune responses were likely due to mucosal invasion along with the generation of colon-isolated lymphoid follicles driving increased fecal and serum IgA by isolate 7, because B and CD4 + T cell depletion not only halted intestinal immune responses but also eliminated detectable clinical disease. In aggregate, these findings demonstrate a mechanism of RA pathogenesis through which a specific intestinal strain of bacteria can drive systemic autoantibody generation and joint-centered antibody deposition and immune activation.

• 2

  A scoping review of biopsychosocial risk factors and co-morbidities for common spinal disorders

  PloS one · 2018

  📚 61 citations🎯 RCR 4.58Top 9% NIH🔓 Open Access📄 PDF gratuit ↗
• 3

  The Global Spine Care Initiative: World Spine Care executive summary on reducing spine-related disability in low- and middle-income communities

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018

  📚 40 citations🎯 RCR 3.01Top 16% NIH

Publications scientifiques (13) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Partager cette fiche