M. Docteur ANDRE MARINI-PORTUGAL

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Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

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• CABINET DU DR ANDRE MARINI-PORTUGAL

  59 RUE DES HEROS NOGENTAIS, 94130 Nogent-sur-Marne

  ☎ 0148723203Libéral
  14 m15 m16 m17 m

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation

  Arthritis and rheumatism · 2004

  📚 98 citations🎯 RCR 2.41Top 21% NIH

  Lire l'abstract Crossref ↓

  AbstractObjectiveThere is evidence that autoimmunity plays a significant role in the pathogenesis of relapsing polychondritis (RP). This study was designed to investigate circulating levels of various cytokines in relation to the etiology of this rare disorder, and to compare the pattern of cytokine elevations in RP with that in another autoimmune disease, rheumatoid arthritis (RA).MethodsSerum from 22 patients with active RP and an equal number of age‐ and sex‐matched healthy controls and RA patients were available for analysis. The following cytokines were measured: interleukin‐1β (IL‐1β), IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12, IL‐13, IL‐17, interferon‐γ (IFNγ), tumor necrosis factor α, granulocyte colony‐stimulating factor (G‐CSF), granulocyte–macrophage colony‐stimulating factor (GM‐CSF), monocyte chemoattractant protein 1 (MCP‐1), and macrophage inflammatory protein 1β (MIP‐1β). Results were analyzed by nonparametric Mann‐Whitney test with Holm stepdown adjustment for multiple testing.ResultsThe levels of 3 of these cytokines showed significant differences between RP patients and controls. Compared with controls, mean serum levels of MCP‐1, MIP‐1β, and IL‐8 were all much higher in patients with active RP. In contrast, RA patients showed a more general increase in all cytokines measured, with much higher levels of IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐10, IL‐13, IFNγ, G‐CSF, GM‐CSF, MCP‐1, and MIP‐1β compared with controls.ConclusionLevels of 3 serum cytokines were significantly higher in RP patients than in age‐ and sex‐matched controls. One of these 3 cytokines, IL‐8, was not significantly elevated in RA samples. Overall, in RP, a more discrete group of cytokines exhibited significantly increased levels than was found in RA. Each of the 3 cytokines that were elevated in RP is a proinflammatory chemokine, characteristic of activation of the monocyte and macrophage lineage, and in the case of IL‐8, also of neutrophils. These data suggest a major role for a cell‐mediated immune response in the pathophysiology of RP.

• 2

  Infliximab to etanercept switch in patients with spondyloarthropathies and psoriatic arthritis: preliminary data

  The Journal of rheumatology · 2005

  📚 58 citations🎯 RCR 1.77🩺 Clinique
• 3

  Marked regression of pulmonary rheumatoid nodules under etanercept therapy

  The Journal of rheumatology · 2009

  📚 7 citations🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (5) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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