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RhumatologueMédecins généralistes et spécialistes👤 Libéral intégral

M. Docteur JEAN-MARC KLEIN

📍 Vandoeuvre-lès-Nancy (54)Libéral💶 Secteur 1RPPS 10002350337

Diplômes

🎓 DES & spécialité ordinale

  • Rhumatologie (SM)

📚 CES (Certificat d'Études Spéciales)

  • CES Rhumatologie

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

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Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

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🟢 Secteur 1 — Tarif conventionnéSource CNAM (Annuaire santé Ameli)
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Top publications · les plus citées

  • 1
    Recent Progress in Cartilage Lubrication

    Advanced materials (Deerfield Beach, Fla.) · 2021

    📚 245 citations🎯 RCR 21.48Top 1% NIH
    Lire l'abstract Crossref ↓

    Abstract Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently‐lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such low friction is indeed essential for its well‐being. It minimizes wear‐and‐tear and hence the cartilage degradation associated with osteoarthritis, the most common joint disease, and, by reducing shear stress on the mechanotransductive, cartilage‐embedded chondrocytes (the only cell type in the cartilage), it regulates their function to maintain homeostasis. Understanding the origins of such low friction of the articular cartilage, therefore, is of major importance in order to alleviate disease symptoms, and slow or even reverse its breakdown. This progress report considers the relation between frictional behavior and the cellular mechanical environment in the cartilage, then reviews the mechanism of lubrication in the joints, in particular focusing on boundary lubrication. Following recent advances based on hydration lubrication, a proposed synergy between different molecular components of the synovial joints, acting together in enabling the low friction, has been proposed. Additionally, recent development of natural and bio‐inspired lubricants is reviewed.

  • 2
    Lubrication of Articular Cartilage

    Annual review of biomedical engineering · 2016

    📚 226 citations🎯 RCR 10.97Top 2% NIH
    Lire l'abstract Crossref ↓

    The major synovial joints such as hips and knees are uniquely efficient tribological systems, able to articulate over a wide range of shear rates with a friction coefficient between the sliding cartilage surfaces as low as 0.001 up to pressures of more than 100 atm. No human-made material can match this. The means by which such surfaces maintain their very low friction has been intensively studied for decades and has been attributed to fluid-film and boundary lubrication. Here, we focus especially on the latter: the reduction of friction by molecular layers at the sliding cartilage surfaces. In particular, we discuss such lubrication in the light of very recent advances in our understanding of boundary effects in aqueous media based on the paradigms of hydration lubrication and of the synergism between different molecular components of the synovial joints (namely hyaluronan, lubricin, and phospholipids) in enabling this lubrication.

  • 3
    Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture

    Pain · 2012

    📚 144 citations🎯 RCR 6.48Top 5% NIH

Publications scientifiques (50) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal35

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IRM ostéo-articulaire3

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Revue générale3

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Génétique2

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Sjögren2

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Épidémiologie & registres1

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Essai clinique1

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IA en rhumatologie1

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Lupus1

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Pédiatrie1

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Revue / méta-analyse1

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