Docteur Dominique KIEFFER

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Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (2)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Grandcamp-Maisy. Une exposition pour rendre hommage au commandant Philippe Kieffer - Actu.fr

  📰 Actu.fr · 28/08/2022

  <a href="https://news.google.com/rss/articles/CBMi2wFBVV95cUxOVWx6NE5MLWMyLUs5R0pSbTdiVjdzbkhlRzZ3bk9rNnRudUxEdk9oQ196X3FTaFc1X3dDVGpSOHRWaE9QeDJPRWduNkhiVjR2ckY2NC1iNGk3Mld2QnJBQkNDRTdKXy1Pa3VOUmNqZHVPTUViNnhla2plLTZvS0NTS2NqTE42SjVfYWxxeXZhZmZ3UzhRbERjT0RqWEU1amRxdVlJTjl1QkFwWlJCVDV1X1dWY2tFWmpNQj

• Mal de dos : la posture souvent coupable - Le Figaro Santé

  📰 Le Figaro Santé · 05/02/2012

  <a href="https://news.google.com/rss/articles/CBMijgFBVV95cUxNbDdHVGNXTHhydG9Ga05WbTdLclJKTVM1SHh2dWsyU2hWa1Q4RzRBaTUxaXVCT281OUVWdkI1dGl2Z3Q5SkJXVXJqVlBsWW9wSVdBblQ5OXktXzFkUHU3RlBSX3FVcHdVSkxneXEyenRXTFlObTNJT0NDRGpZRmxQck9URWU1WXVpRkROb2RR?oc=5" target="_blank">Mal de dos : la posture souvent cou

Top publications · les plus citées

• 1

  Using chest computed tomography and unsupervised machine learning for predicting and evaluating response to lumacaftor-ivacaftor in people with cystic fibrosis

  The European respiratory journal · 2022

  📚 31 citations🎯 RCR 3.17Top 15% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  ObjectivesLumacaftor-ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator known to improve clinical status in people with cystic fibrosis (CF). This study aimed to assess lung structural changes after one year of lumacaftor-ivacaftor treatment, and to use unsupervised machine learning to identify morphological phenotypes of lung disease that are associated with response to lumacaftor-ivacaftor.MethodsAdolescents and adults with CF from the French multicenter real-world prospective observational study evaluating the first year of treatment with lumacaftor-ivacaftor were included if they had pretherapeutic and follow-up chest computed tomography (CT)-scans available. CT scans were visually scored using a modified Bhalla score. A k-mean clustering method was performed based on 120 radiomics features extracted from unenhanced pretherapeutic chest CT scans.ResultsA total of 283 patients were included. The Bhalla score significantly decreased after 1 year of lumacaftor-ivacaftor (−1.40±1.53 points compared with pretherapeutic CT; p&lt;0.001). This finding was related to a significant decrease in mucus plugging (−0.35±0.62 points; p&lt;0.001), bronchial wall thickening (−0.24±0.52 points; p&lt;0.001) and parenchymal consolidations (−0.23±0.51 points; p&lt;0.001). Cluster analysis identified 3 morphological clusters. Patients from cluster C were more likely to experience an increase in percent predicted forced expiratory volume in 1 sec (ppFEV1) ≥5 under lumacaftor–ivacaftor than those in the other clusters (54% of responders versus 32% and 33%; p=0.01).ConclusionOne year treatment with lumacaftor-ivacaftor was associated with a significant visual improvement of bronchial disease on chest CT. Radiomics features on pretherapeutic CT scan may help in predicting lung function response under lumacaftor-ivacaftor.

• 2

  [Polyarthritis in leprosy (author's transl)]

  La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1979

  📚 10 citations
• 3

  [HL-A DRw4 in rheumatoid polyarthritis. Results of personal research]

  Revue du rhumatisme et des maladies osteo-articulaires · 1980

  📚 4 citations

Publications scientifiques (7) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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