M. Docteur JEAN GRANEL

Thèses universitaires

• Maladie de paget de l'os traitee par pamidronate

  1994
  Médecine🎓 Toulouse 3

  Direction : Bernard Fournié

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieu de consultation

• CABINET DU DR JEAN GRANEL

  24 RUE DES FRERES LION, 31000 Toulouse

  ☎ 05616306Libéral
  59 m60 m65 m71 m

  © OpenStreetMap · Photos Wikimedia Commons (CC)

  📷 Street View ↗🗺️ Maps ↗OSM ↗

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Flourens. Corinne Vignon a présenté sa liste - ladepeche.fr

  📰 ladepeche.fr · 04/03/2014

  <a href="https://news.google.com/rss/articles/CBMiogFBVV95cUxQU3Nfem5mTF9GM1N0c0Q0QVJ5aUhuSEVRcnRPSDg3cE1fVTdPWFJWbzNJWFRUbHRPVjBVUkFCWDRNUmtrVXRDRm9CWDBwcU9vcGNNQXZkT1QwY0wwOHZudUhhNDNDeTF3TmtxbEVxM0FESG9uWGlmanVyNmFmeG9nTS0zdFpRMjFQNTJRM1d0RkNGZEVOb1pYdmZFWnRtTEdNd0E?oc=5" target="_blank">Flourens

Top publications · les plus citées

• 1

  Prospective study of anterior chest wall involvement in ankylosing spondylitis and psoriatic arthritis

  Revue du rhumatisme (English ed.) · 1997

  📚 33 citations🎯 RCR 1.58🩺 Clinique
• 2

  Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies

  Frontiers in immunology · 2021

  📚 26 citations🎯 RCR 2.09🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Granulomatosis with polyangiitis (GPA) is a rare but serious necrotizing auto-immune vasculitis. GPA is mostly associated with the presence of Anti-Neutrophil Cytoplasmic Antibody (ANCA) targeting proteinase 3 (PR3-ANCA), a serine protease contained in neutrophil granules but also exposed at the membrane. PR3-ANCAs have a proven fundamental role in GPA: they bind neutrophils allowing their auto-immune activation responsible for vasculitis lesions. PR3-ANCAs bind neutrophil surface on the one hand by their Fab binding PR3 and on the other by their Fc binding Fc gamma receptors. Despite current therapies, GPA is still a serious disease with an important mortality and a high risk of relapse. Furthermore, although PR3-ANCAs are a consistent biomarker for GPA diagnosis, relapse management currently based on their level is inconsistent. Indeed, PR3-ANCA level is not correlated with disease activity in 25% of patients suggesting that not all PR3-ANCAs are pathogenic. Therefore, the development of new biomarkers to evaluate disease activity and predict relapse and new therapies is necessary. Understanding factors influencing PR3-ANCA pathogenicity,i.e.their potential to induce auto-immune activation of neutrophils, offers interesting perspectives in order to improve GPA management. Most relevant factors influencing PR3-ANCA pathogenicity are involved in their interaction with neutrophils: level of PR3 autoantigen at neutrophil surface, epitope of PR3 recognized by PR3-ANCA, isotype and glycosylation of PR3-ANCA. We detailed in this review the advances in understanding these factors influencing PR3-ANCA pathogenicity in order to use them as biomarkers and develop new therapies in GPA as part of a personalized approach.

• 3

  A new family with hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease as prevailing symptoms

  BMC gastroenterology · 2014

  📚 19 citations🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (25) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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