Docteur Pauline BREVET

Thèses universitaires

• La répοnse anti-fibrinοgène carbamylé dans la pοlyarthrite rhumatοide : identificatiοn des cibles antigéniques et significatiοn clinique

  2025

  The anti–carbamylated fibrinogen response in rheumatoid arthritis : identification of antigenic targets and clinical significance

  Aspects moleculaires et cellulaires de la biologie🎓 Normandie

  Direction : Olivier Vittecoq, Olivier Boyer

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Early postoperative activity tracking shows excessive ambulation and poor adherence to recommendations after hallux valgus surgery

  2026

  ArticleOrthopaedics & Traumatology: Surgery & Research

• Autoantibody fine specificity restriction is associated with clinical response in RA treated with abatacept and methotrexate

  2026

  ArticleClinical Immunology

• Could the anti-modified protein antibody concept help better define seronegative rheumatoid arthritis?

  2025

  ArticleJoint Bone Spine

• Evaluation by modern imaging of anterior chest wall involvement in axial spondyloarthritis with or without chest complaint

  2025

  ArticleJoint Bone Spine

• Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort

  2025

  ArticleRMD Open

• Comparative analysis of clinical profile, therapeutic management, and clinical prognosis of patients with seropositive or seronegative rheumatoid arthritis following the introduction of a first targeted therapy in a real-life setting

  2025

  ArticleClinical Rheumatology

• Evaluation of the nocebo effect after switching from etanercept or adalimumab originator to a biosimilar: a retrospective study of patients with inflammatory rheumatism

  2025

  ArticleClinical and experimental rheumatology

• Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis

  2024

  ArticleRMD Open

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieu de consultation

• HOPITAL CHARLES NICOLLE CHU ROUEN

  1 Rue DE GERMONT, 76000 Rouen

  ☎ 0232888990Hospitalier🏥 Centre CHU ↗🏥 Voir cet établissement
  176 m183 m198 m198 m

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Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies

  Frontiers in immunology · 2021

  📚 11 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate their prognostic value. 331 patients (184 RA and 147 other rheumatisms) from the Very Early Arthritis (VErA) French cohort were analyzed. We performed mass spectrometry analysis of RA sera displaying anti-CarP activity and epitope mapping of the carbamylated fibrinogen γ chain to identify immunodominant peptides. The specificity of these targets was studied using competition assays with the major antigens recognized by ACPA. The prognostic value of anti-carbamylated fibrinogen IgG antibodies (ACa-Fib IgG) was compared to that of anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-CarP using an in-house ELISA. Besides the α chain, the γ chain of fibrinogen, particularly one immunodominant epitope that has a specific reactivity, was identified as a circulating carbamylated target in sera. The prevalence of ACa-Fib was 37% at baseline and 10.9% for anti-CCP-negative RA. In anti-CCP-negative patients, ACa-Fib positivity was associated with a more inflammatory and erosive disease at baseline but not with rapid radiological progression, which remains strongly related to anti-CCP antibodies. Fibrinogen seems to be one of the antigens recognized in vivo by the anti-CarP response, particularly 2 epitopes of the γ chain, one of which is not cross reactive with ACPA. This specificity might be associated with a distinct clinical phenotype since ACa-Fib IgG were shown to be linked to systemic inflammation in very early RA but not to rapid radiological progression.

• 2

  Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry

  The Journal of infection · 2024

  📚 10 citations🎯 RCR 3.31Top 14% NIH🔓 Open Access📄 PDF gratuit ↗
• 3

  Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis

  RMD open · 2024

  📚 4 citations🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (23) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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