Docteur MARION HERBETTE

Thèses universitaires

• Étude de la fonction de l’histone méthyltransférase SET-2 et de ses interacteurs dans le maintien de la lignée germinale de Caenorhabditis elegans

  2019

  Study of the Caenorhabditis elegans SET-2 histone methyltransferase and its interactors in germline maintenance

  Biologie🎓 Lyon

  Direction : Valérie Robert

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Histone removal in sperm protects paternal chromosomes from premature division at fertilization

  2023

  ArticleScience

• Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans

  2023

  ArticlePLoS Biology

• Stable efficacy and safety after switching from intravenous to subcutaneous tocilizumab in a cohort of 200 patients in real life conditions

  2022

  ArticleJoint Bone Spine

• Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

  2021

  ArticlePLoS Genetics

• A Role for Caenorhabditis elegans COMPASS in Germline Chromatin Organization

  2020

  ArticleCells

• Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans

  2019

  ArticleNucleic Acids Research

• Étude de la fonction de l’histone méthyltransférase SET-2 et de ses interacteurs dans le maintien de la lignée germinale de Caenorhabditis elegans

  2019

  Thèse

• Spinal-pelvic orientation: potential effect on the diagnosis of spondyloarthritis

  2019

  ArticleRheumatology

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans

  Nucleic acids research · 2019

  📚 41 citations🎯 RCR 1.40🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex. Supporting a functional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact and have similar phenotypic defects including misregulation of common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 domain and recruits SIN-3 and the HDA-1/HDAC subunit to H3K4me3 enriched promoters. Our results reveal a novel role for CFP-1 in mediating interaction between SET1/COMPASS and a Sin3S HDAC complex at promoters.

• 2

  Histone removal in sperm protects paternal chromosomes from premature division at fertilization

  Science (New York, N.Y.) · 2023

  📚 22 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  The global replacement of histones with protamines in sperm chromatin is widespread in animals, including insects, but its actual function remains enigmatic. We show that in the Drosophila paternal effect mutant paternal loss ( pal ), sperm chromatin retains germline histones H3 and H4 genome wide without impairing sperm viability. However, after fertilization, pal sperm chromosomes are targeted by the egg chromosomal passenger complex and engage into a catastrophic premature division in synchrony with female meiosis II. We show that pal encodes a rapidly evolving transition protein specifically required for the eviction of (H3-H4) 2 tetramers from spermatid DNA after the removal of H2A-H2B dimers. Our study thus reveals an unsuspected role of histone eviction from insect sperm chromatin: safeguarding the integrity of the male pronucleus during female meiosis.

• 3

  Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

  PLoS genetics · 2021

  📚 19 citations🎯 RCR 1.27🔓 Open Access

  Lire l'abstract Crossref ↓

  Segregation Distorter ( SD ) is a male meiotic drive system in Drosophila melanogaster . Males heterozygous for a selfish SD chromosome rarely transmit the homologous SD + chromosome. It is well established that distortion results from an interaction between Sd , the primary distorting locus on the SD chromosome and its target, a satellite DNA called Rsp , on the SD + chromosome. However, the molecular and cellular mechanisms leading to post-meiotic SD + sperm elimination remain unclear. Here we show that SD/SD + males of different genotypes but with similarly strong degrees of distortion have distinct spermiogenic phenotypes. In some genotypes, SD + spermatids fail to fully incorporate protamines after the removal of histones, and degenerate during the individualization stage of spermiogenesis. In contrast, in other SD/SD + genotypes, protamine incorporation appears less disturbed, yet spermatid nuclei are abnormally compacted, and mature sperm nuclei are eventually released in the seminal vesicle. Our analyses of different SD + chromosomes suggest that the severity of the spermiogenic defects associates with the copy number of the Rsp satellite. We propose that when Rsp copy number is very high (> 2000), spermatid nuclear compaction defects reach a threshold that triggers a checkpoint controlling sperm chromatin quality to eliminate abnormal spermatids during individualization.

Publications scientifiques (10) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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