Docteur Dominique BRUNEAU-ENGALENC
✨ Profil synthétique
IA · 29/04/2026Le Docteur Dominique BRUNEAU-ENGALENC est un rhumatologue hospitalier à Bourges. Ses publications sur PubMed couvrent divers sujets, notamment les biothérapies non-anti-TNF, l'épidémiologie et les registres, ainsi que l'arthrite juvénile. Il a également publié des revues générales et des cas cliniques.
Expertises présumées
- Biothérapies non-anti-TNF
- Épidémiologie en rhumatologie
- Arthrite juvénile
- Méta-analyse en rhumatologie
- Thérapeutique des maladies rhumatismales
- Registres de maladies rhumatismales
- Revue de cas en rhumatologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- Rhumatologie (SM)
🏅 DU / DIU
- DU Etudes de réparation du dommage corporel
📚 CES (Certificat d'Études Spéciales)
- CES Rhumatologie
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Localisation
Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.
Lieu de consultation
GIP MAISON DEP PERSONNES HANDICAPEES
PYRAMIDES DU CONSEIL DEPARTEMENTAL — 7 RTE DE GUERRY, 18000 Bourges
Hospitalier© OpenStreetMap
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
Cancer discovery · 2025
Lire l'abstract Crossref ↓
Abstract Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. In this study, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing antiproliferative changes in tumor cells. Our findings are supported by biochemical and structural analysis, in vitro and in vivo transcriptomics, and functional data, revealing the recovery of multiple aspects of the wild-type p53 program. These compounds demonstrate potent antitumor activity in preclinical models as single agents and in combination with immunotherapy. Currently, rezatapopt is being evaluated in a registrational phase II clinical trial for patients with advanced solid tumors harboring the TP53 Y220C mutation. Significance: Rezatapopt is a clinical-stage compound that offers a promising treatment option for TP53-mutant cancers. This study details the characterization of rezatapopt and its related compounds, which can reinstate the tumor suppressor activity of the p53 Y220C mutant. These results emphasize the potential for targeting p53 mutations in cancer therapy.
- 2Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development
ACS medicinal chemistry letters · 2025
- 3Malignancy outcomes in patients with rheumatoid arthritis treated with abatacept and other disease-modifying antirheumatic drugs: Results from a 10-year international post-marketing study
Seminars in arthritis and rheumatism · 2024
📚 15 citations🎯 RCR 4.23Top 10% NIH🩺 Clinique🔓 Open Access
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal37
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Transversal37
▼- Medication adherence to cystic fibrosis transmembrane conductance regulator (CFTR) modulators: Analysis on the French cystic fibrosis population from 2012-2020
Respiratory medicine · 2026 · Journal Article
Eid E, Payet C, Fernandez V, Belhassen M, et al.
- Lung cancer screening by low-dose computed tomography: A modelling study to evaluate radiation-induced cancer risks, and the influence of smoking behavior
Cancer epidemiology · 2026 · Journal Article
Nicolas M, Agnès R, Christophe B, Julie S, et al.
- The Combination of Motor Imagery and Breathing Optimizes the Performance of the Serve in Skilled Tennis Players
Sports health · 2026 · Journal Article
Robin N, Carien R, Bonnin T, Michineau L, et al.
- Adrenal Insufficiency (Nursing)
Journal inconnu · 2026 · Study Guide
Huecker MR, Bhutta BS, Dominique E, Bossuah KA
- Acute Abdomen
Journal inconnu · 2026 · Study Guide
Kopitnik NL, Kashyap S, Dominique E
- Adrenal Insufficiency
Journal inconnu · 2026 · Study Guide
Huecker MR, Bhutta BS, Dominique E
- Abdominal Compartment Syndrome
Journal inconnu · 2026 · Study Guide
Popowicz P, Newman RK, Dominique E
- Catchment Productivity Controls Local Species Richness of Hyporheic Invertebrate Communities in Tropical New Caledonia Streams
Ecology and evolution · 2025 · Journal Article
Mouron S, Dominique Y, Eme D, Tombers N, et al.
- Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host
Aging and cancer · 2025 · Journal Article
Wang Z, Liu Y, Yang J, Hilliard TS, et al.
- Lowering plasma S-Adenosylhomocysteine (SAH) in healthy adults with elevated SAH and normal homocysteine using nutritional supplementation
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025 · Journal Article
Pohl F, Dominique A, Dufour J, Wang J, et al.
🩺 Clinique - Impact of orthodontic treatment on front teeth with prior history of dental injury: a 4-year follow up
Clinical oral investigations · 2025 · Journal Article
Alex F, Sofie F, Gertrude VG, Dominique D, et al.
- Nutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine
PloS one · 2025 · Journal Article
Surzenko N, Dominique A, Hanania T, Osborne M, et al.
📚 1 cit. - Efficacy of age, menopause, and dental radiographic measures in identifying women at risk of spine Osteoporosis: an investigation panorama
Biomedical physics & engineering express · 2025 · Journal Article
D K, D P, P V, G A, et al.
- Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
Cancer discovery · 2025 · Journal Article
Puzio-Kuter AM, Xu L, McBrayer MK, Dominique R, et al.
📚 34 cit.🎯 RCR 11.56🔬→🩺 Translationnel - Chloronychia: Green Nail Syndrome Caused by Pseudomonas aeruginosa in a Younger Patient
Cureus · 2025 · Case Reports
Dominique WT, Obasi E, Sidhu S
- The snoRNP chaperone snR190 and the Npa1 complex form a macromolecular assembly required for 60S ribosomal subunit maturation
Nucleic acids research · 2025 · Journal Article
Hamze H, Jaafar M, Khreiss A, Dominique C, et al.
📚 2 cit. - Modulation of morphine antinociceptive and rewarding effect by mirtazapine in an animal model of osteoarthritic pain
European journal of pharmacology · 2025 · Journal Article
N P, M M G, C RR, D P, et al.
📚 2 cit. - Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development
ACS medicinal chemistry letters · 2025 · Journal Article
Vu BT, Dominique R, Fahr BJ, Li HH, et al.
📚 26 cit.🎯 RCR 3.57🔬→🩺 Translationnel - Constituents, Nutrient Content, and In Vitro Antioxidant and Anti-Inflammatory Activity of Tricholomopsis aurea (Agaricomycetes) from Cameroon
International journal of medicinal mushrooms · 2025 · Journal Article
Ndifor AR, Dominique N, Claude MD, Raoul K, et al.
📚 1 cit. - "It's my Home away from Home:" A hermeneutic phenomenological study exploring decision-making experiences of choosing a freestanding birth centre for perinatal care
Midwifery · 2024 · Journal Article
George EK, Dominique S, Irie W, Edmonds JK
📚 2 cit.🎯 RCR 1.27 - Remodelling of Rea1 linker domain drives the removal of assembly factors from pre-ribosomal particles
Nature communications · 2024 · Journal Article
Busselez J, Koenig G, Dominique C, Klos T, et al.
📚 1 cit. - Intravascular Resuscitation Benefits Compared to Lactulose in Dehydration-Associated Pseudo-Hyperammonemia Causing Altered Mental Status
Cureus · 2024 · Case Reports
Olukayode O, Balaji N, Dominique W, Boban A, et al.
- Identifying and Evaluating Online Kidney Stone Pain Resources: A Cross-Sectional Study
Cureus · 2024 · Journal Article
Hernandez CJ, Lim J, Takele R, Escobedo F, et al.
📚 1 cit. - The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction
Nature communications · 2024 · Journal Article
Dominique C, Maiga NK, Méndez-Godoy A, Pillet B, et al.
📚 10 cit.🎯 RCR 1.43 - Assessment of the Risks of Zoonotic Infection at the Primatology Centre of the Interdisciplinary Medical Research Centre of Franceville in Gabon
Journal of medical primatology · 2024 · Journal Article
Jean NN, Désiré OE, Serge Ely D, Larson B, et al.
- Pre-, Per- and post-cooling strategies used by competitive tennis players in hot dry and hot humid conditions
Frontiers in sports and active living · 2024 · Journal Article
Robin N, Crespo M, Ishihara T, Carien R, et al.
- Feasibility and acceptability of a serious game to study the effects of environmental distractors on emergency room nurse triage accuracy: A pilot study
International emergency nursing · 2024 · Journal Article
Assunta F, Matteo A, Séverine V, Guy S, et al.
🩺 Clinique - Effects of the Beijing genotype on latent tuberculosis infection, TB disease risk, and clustering of TB cases
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024 · Journal Article
Asare-Baah M, Séraphin MN, Salmon-Trejo LAT, Johnston L, et al.
📚 1 cit. - Mechanisms and Intervention of Prebiotic Foods in Musculoskeletal Health
The Journal of nutrition · 2024 · Journal Article
Lakshmanan DK, Ravichandran G, Elangovan A, D AA, et al.
📚 1 cit. - Clinical phenotype of adult-onset systemic histiocytosis harboring BRAF in-frame deletions
Haematologica · 2024 · Letter
Papo M, Razanamahéry J, Da Silva M, Hélias-Rodzewicz Z, et al.
📚 3 cit. - K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment
Molecular cell · 2024 · Journal Article
Garadi Suresh H, Bonneil E, Albert B, Dominique C, et al.
📚 4 cit. - CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma
Chest · 2024 · Journal Article
Godet C, Brun AL, Couturaud F, Laurent F, et al.
📚 6 cit.🎯 RCR 1.67🩺 Clinique - Unravelling the Relacatib activity against the CTSK proteins causing pycnodysostosis: a molecular docking and dynamics approach
Journal of biomolecular structure & dynamics · 2024 · Journal Article
Kannan P, A HB, N MP, D TK, et al.
📚 2 cit. - Correction: Improving the Engagement of Underrepresented People in Health Research Through Equity-Centered Design Thinking: Qualitative Study and Process Evaluation for the Development of the Grounding Health Research in Design Toolkit
JMIR formative research · 2024 · Published Erratum
Bazzano AN, Noel LA, Patel T, Dominique CC, et al.
📚 1 cit. - Similarities and differences of interstitial lung disease associated with pathogenic variants in SFTPC and ABCA3 in adults
Respirology (Carlton, Vic.) · 2024 · Journal Article
Diesler R, Legendre M, Si-Mohamed S, Brillet PY, et al.
📚 12 cit.🎯 RCR 2.76🔬→🩺 Translationnel - New treatment paradigm for patients with Marfan or Loyes-Dietz syndrome
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024 · Editorial
Haulon S, Guo MH, Dominique F
📚 2 cit. - Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024 · Journal Article
Surzenko N, Bastidas J, Reid RW, Curaba J, et al.
📚 3 cit.
Biothérapies non-anti-TNF4
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Biothérapies non-anti-TNF4
▼- Safety and effectiveness of abatacept in juvenile idiopathic arthritis: results from the PRINTO/PRCSG registry
Rheumatology (Oxford, England) · 2024 · Journal Article
Lovell DJ, Tzaribachev N, Henrickson M, Simonini G, et al.
📚 13 cit.🎯 RCR 3.27🩺 Clinique - Infection outcomes in patients with rheumatoid arthritis treated with abatacept and other disease-modifying antirheumatic drugs: Results from a 10-year international post-marketing study
Seminars in arthritis and rheumatism · 2024 · Observational Study
Simon TA, Suissa S, Skovron ML, Frisell T, et al.
📚 11 cit.🎯 RCR 2.79🩺 Clinique - Malignancy outcomes in patients with rheumatoid arthritis treated with abatacept and other disease-modifying antirheumatic drugs: Results from a 10-year international post-marketing study
Seminars in arthritis and rheumatism · 2024 · Observational Study
Simon TA, Suissa S, Boers M, Hochberg MC, et al.
📚 15 cit.🎯 RCR 4.23🩺 Clinique - Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies
Annals of the rheumatic diseases · 2024 · Journal Article
Simon TA, Dong L, Suissa S, Michaud K, et al.
📚 14 cit.🎯 RCR 3.65
Épidémiologie & registres2
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Épidémiologie & registres2
▼- Timing and predictors of disease incidence among named contacts of reported tuberculosis patients in a low incidence setting
PloS one · 2025 · Journal Article
Asare-Baah M, Johnston L, Dominique L, Lauzardo M, et al.
- Genotyped cluster investigations versus standard contact tracing: comparative impact on latent tuberculosis infection cascade of care in a low-incidence region
BMC infectious diseases · 2025 · Journal Article
Asare-Baah M, Séraphin MN, Salmon-Trejo LAT, Johnston L, et al.
Revue / méta-analyse2
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Revue / méta-analyse2
▼- Use of Lasers in the Nonsurgical Treatment of Peri-Implantitis: A Systematic Review of the Literature
The Journal of oral implantology · 2024 · Journal Article
Dominique C, Rethoré G, Verner C, Alliot C, et al.
📚 2 cit. - Naturopathic Interventions for Reduction of Perceived Pain in Patients Suffering from Arthritis: A Systematic Review and Meta-Analysis
Cureus · 2024 · Journal Article
Mondal H, Komarraju S, D S, Muralidharan S
📚 1 cit.
Revue générale2
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Revue générale2
▼- Use of Lasers in the Nonsurgical Treatment of Peri-Implantitis: A Systematic Review of the Literature
The Journal of oral implantology · 2024 · Journal Article
Dominique C, Rethoré G, Verner C, Alliot C, et al.
📚 2 cit. - Naturopathic Interventions for Reduction of Perceived Pain in Patients Suffering from Arthritis: A Systematic Review and Meta-Analysis
Cureus · 2024 · Journal Article
Mondal H, Komarraju S, D S, Muralidharan S
📚 1 cit.
Arthrite juvénile1
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Arthrite juvénile1
▼- Safety and effectiveness of abatacept in juvenile idiopathic arthritis: results from the PRINTO/PRCSG registry
Rheumatology (Oxford, England) · 2024 · Journal Article
Lovell DJ, Tzaribachev N, Henrickson M, Simonini G, et al.
📚 13 cit.🎯 RCR 3.27🩺 Clinique
Case report / série1
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Case report / série1
▼- A Decade With Sheehan's Syndrome: A Case Report and Personal Experience
Case reports in endocrinology · 2025 · Case Reports
D K, Moradeyo AY, G B
csDMARDs1
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csDMARDs1
▼- Therapy related myelodysplastic syndrome: a hematologic sequela of low dose methotrexate in rheumatoid arthritis
Oxford medical case reports · 2025 · Case Reports
Gupta A, D V, Nawaz A, Hari V
Essai clinique1
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Essai clinique1
▼- Transvaginal Electrical Stimulation for Treatment of Overactive Bladder Without Incontinence: A Pilot Cross-Over Clinical Trial
Neurourology and urodynamics · 2025 · Journal Article
Torosis M, Stothers L, Cisneros C, Dominique G, et al.
📚 2 cit.🩺 Clinique
IA en rhumatologie1
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IA en rhumatologie1
▼- Machine learning for the prediction of urosepsis using electronic health record data
PLOS digital health · 2025 · Journal Article
Sarwal V, Rakocz N, Dominique G, Chiang JN, et al.
📚 2 cit.
Vascularites1
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Vascularites1
▼- Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study
Seminars in arthritis and rheumatism · 2024 · Journal Article
Monghal V, Puéchal X, Smets P, Vandergheynst F, et al.
📚 4 cit.