Docteur FADELA DAOUED

Bibliographie

• Brief Report: Relationship Between Serum Infliximab Concentrations and Risk of Infections in Patients Treated for Spondyloarthritis

  2017

  ArticleArthritis & rheumatology

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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Top publications · les plus citées

• 1

  Brief Report: Relationship Between Serum Infliximab Concentrations and Risk of Infections in Patients Treated for Spondyloarthritis

  Arthritis & rheumatology (Hoboken, N.J.) · 2017

  📚 29 citations🎯 RCR 1.38

  Lire l'abstract Crossref ↓

  ObjectiveTumor necrosis factor inhibitors are effective in reducing inflammation in rheumatic diseases but increase the risk of infections. This study was undertaken to investigate the relationship between the trough serum concentration of infliximab (IFX) and the risk of a first infection episode.MethodsWe retrospectively included all patients who started IFX treatment for an approved indication in our department. Patients were followed up based on recommended IFX infusion schedules. We studied the relationship between the occurrence of a first infection episode requiring hospitalization, anti‐infection treatment, or IFX infusion deferral, and the last trough IFX concentration and mean of the last 3 trough IFX concentrations measured before the infection episode.ResultsOf the 201 patients included in the analysis, 173 had spondyloarthritis (SpA). The SpA patients had a mean ± SD age of 46 ± 12 years and a disease duration of 6.2 ± 6.1 years. During a median follow‐up of 1.1 year, 87 SpA patients had at least 1 infection episode. Using Cox models, we found that the probability of survival without infection was significantly higher in patients with a mean of the last 3 trough IFX concentrations lower than the median (<11.3 mg/liter) than in patients with a mean concentration greater than the median (P = 0.048 by log‐rank test). Glucocorticoid use and IFX concentration were significantly associated with the risk of a first infection episode in the multivariable analysis (P = 0.004 for both). The risk of infection episode was significantly increased in the highest quartile of the mean of the last 3 trough IFX concentrations (>20.3 mg/liter) (hazard ratio 2.65 [95% confidence interval 1.14–6.14], P = 0.023).ConclusionOur findings indicate that a high IFX concentration is correlated with a higher risk of a first infection episode, but these findings need to be replicated in further prospective studies.

• 2

  Orbital Myositis and Primary Sjögren Syndrome

  The Journal of rheumatology · 2015

  📚 8 citations🔓 Open Access📄 PDF gratuit ↗
• 3

  Simple and fast diagnosis of osteoporosis based on UV-visible hair fluorescence spectroscopy

  Applied optics · 2020

  📚 3 citations

  Lire l'abstract Crossref ↓

  The aim of this work is to propose a new analytical technique based on UV–visible fluorescence as an alternative to x-ray absorptiometry for diagnosing osteoporosis, as well as its early stage by identifying osteopenia. The equipment used consists of very cheap equipment compared to x-ray scanners with an LED as the excitation source. In this work, we analyzed 90 hair samples taken from volunteers of different ages at Habib Thameur Hospital in Tunis. These samples were previously analyzed by bone mineral density (BMD) and correspond to people suffering from osteoporosis and osteopenia, as well as healthy people. The main idea of this study is to show the correlation between the deficiency of bone density given by BMD and the variations of the relative concentrations of molecules present in the hair causing the changes observed in the fluorescence spectra. The results extracted from the spectra show a clear discrimination between healthy and sick patients and a very good correlation, in a Spearman sense, between the spectral measurements and the BMD’s data for the patients with osteoporosis. In addition, we have isolated the main spectral region responsible for this correlation, which facilitates the identification of the molecule concentrations related to the decrease in BMD.

Publications scientifiques (4) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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