Docteur Marie BEAUFRÈRE

Thèses universitaires

• Rôle de la dysbiose du microbiote intestinal et réponse Th17 dans les spondyloarthrites : pathogénie et causalité

  2024

  Role of gut microbiota dysbiosis and Th17 response in spondyloarthritis : pathogenesis and causation

  Microbiologie🎓 université Paris-Saclay

  Direction : Maxime Bréban, Philippe Langella, Simon Glatigny

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Rethinking HLA-B27 Testing: What HLA-B27 Can— and Cannot—Tell Us

  2025

  ArticleJournal of Rheumatology

• Interleukin 17-producing C-C motif chemokine receptor 6 + conventional CD4+ T cells are arthritogenic in an animal model of spondyloarthritis

  2025

  ArticleJournal of Autoimmunity

• Intestinal dysbiosis in spondyloarthritis – chicken or egg?

  2021

  ArticleCurrent Opinion in Rheumatology

• Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots

  2021

  ArticleFrontiers in Immunology

• Lessons on SpA pathogenesis from animal models

  2021

  ArticleSeminars in Immunopathology

• The microbiome in spondyloarthritis

  2019

  ArticleBest Practice and Research: Clinical Rheumatology

• Extending the ALDH18A1 clinical spectrum to severe autosomal recessive fetal cutis laxa with corpus callosum agenesis

  2018

  ArticleAmerican Journal of Medical Genetics Part A

• FDG PET-CT as a powerful tool for diagnosing and monitoring treatment outcomes of relapsing polychondritis

  2018

  ArticleEuropean Journal of Nuclear Medicine and Molecular Imaging

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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Top publications · les plus citées

• 1

  The microbiome in spondyloarthritis

  Best practice & research. Clinical rheumatology · 2019

  📚 29 citations🎯 RCR 1.28
• 2

  Lessons on SpA pathogenesis from animal models

  Seminars in immunopathology · 2021

  📚 18 citations🎯 RCR 1.09
• 3

  Intestinal dysbiosis in spondyloarthritis - chicken or egg?

  Current opinion in rheumatology · 2021

  📚 10 citations

  Lire l'abstract Crossref ↓

  Purpose of review The well-established link between intestinal inflammation and spondyloarthritis (SpA) remains largely unexplained. Recent sequencing technologies have given access to a thorough characterization of the gut microbiota in healthy and disease conditions. This showed that inflammatory bowel disease (IBD) is associated with dysbiosis – i.e., disturbed gut microbiota composition – which may contribute to disease pathogenesis. Whether gut dysbiosis exists in SpA and could contribute to disease development or be a bystander consequence of chronic inflammation is a question of major interest. Recent findings Several metagenomic studies have been performed in SpA. Most of them concerned faecal samples and showed dysbiosis consisting in a reduction of microbial biodiversity in a way similar to what has been described in IBD. They also highlighted changes in microbial taxa composition that could contribute to the inflammatory process. Likewise, healthy carriers of human leukocyte antigen (HLA)-B27 exhibited gut dysbiosis, indicating that this predisposing allele could exert its pathogenic effect by influencing microbiota composition, and possibly by driving antigen-specific cross-reactive immune response. On the other hand, SpA treatments were associated with a reduction of dysbiosis, showing that it is at least in part a consequence of inflammation. Summary Recent insights from metagenomic studies warrant further investigations to identify the mechanisms by which microbial dysbiosis could contribute to SpA development. This would bring novel therapeutic opportunities aiming at correcting detrimental changes.

Publications scientifiques (8) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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