M. Docteur Sebastien WEILL-ENGERER

Thèses universitaires

• Neurostéroi͏̈des, vieillissement et maladie d'Alzheimer : aspects physiologiques et métaboliques

  2002
  Signalisation cellulaire, endocrinologie, reproduction🎓 Paris 11

  Direction : Étienne-Emile Baulieu

• Comparaison des mesures femorales par absorptiometrie x et par ultrasons sur le calcaneum pour l'analyse du risque de fracture du col du femur

  1993
  Médecine🎓 Lyon 1

  Direction : Pierre Meunier

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• In vitro metabolism of dehydroepiandrosterone (DHEA) to 7α-hydroxy-DHEA and Δ5-androstene-3β,17β-diol in specific regions of the aging brain from Alzheimer’s and non-demented patients

  2003

  ArticleBrain Research

• Neurosteroid Quantification in Human Brain Regions: Comparison between Alzheimer’s and Nondemented Patients

  2002

  ArticleJournal of Clinical Endocrinology and Metabolism

• Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry

  2000

  ArticleJournal of Chromatography B Biomedical Sciences and Applications

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

• CABINET DU DR SEBASTIEN WEILL-ENGERER

  27 RUE TAINE, 75012 Paris

  Libéral
  11 m13 m13 m21 m

  © OpenStreetMap · Photos Wikimedia Commons (CC)

  📷 Street View ↗🗺️ Maps ↗OSM ↗

• GHU APHP SUN SITE ROTHSCHILD

  5 Rue SANTERRE, 75571 Paris 12e Arrondissement

  ☎ 0140193000Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients

  The Journal of clinical endocrinology and metabolism · 2002

  📚 272 citations🎯 RCR 6.94Top 5% NIH

  Lire l'abstract Crossref ↓

  Abstract Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the physiopathological significance of neurosteroids in Alzheimer’s disease (AD), we compared the concentrations of pregnenolone, pregnenolone sulfate (PREGS), dehydroepiandrosterone, dehydroepiandrosterone sulfate (DHEAS), progesterone, and allopregnanolone, measured by gas chromatography-mass spectrometry, in individual brain regions of AD patients and aged nondemented controls, including hippocampus, amygdala, frontal cortex, striatum, hypothalamus, and cerebellum. A general trend toward decreased levels of all steroids was observed in all AD patients’ brain regions compared with controls: PREGS and DHEAS were significantly lower in the striatum and cerebellum, and DHEAS was also significantly reduced in the hypothalamus. A significant negative correlation was found between the levels of cortical β-amyloid peptides and those of PREGS in the striatum and cerebellum and between the levels of phosphorylated tau proteins and DHEAS in the hypothalamus. This study provides reference values for steroid concentrations determined by gas chromatography-mass spectrometry in various regions of the aged human brain. High levels of key proteins implicated in the formation of plaques and neurofibrillary tangles were correlated with decreased brain levels of PREGS and DHEAS, suggesting a possible neuroprotective role of these neurosteroids in AD.

• 2

  Sarcopenia is predictive of nosocomial infection in care of the elderly

  The British journal of nutrition · 2006

  📚 193 citations🎯 RCR 5.72Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Protein–energy malnutrition and nosocomial infection (NI) are frequent in elderly patients, and a causal link between the two has often been suggested. The aim of the present study was to identify the nutritional parameters predictive of NI in elderly patients. We assessed on admission 101 patients (sixty-six women, thirty-five men, aged over 65 years) admitted to an acute care of the elderly department. Sarcopenia was detected by dual-energy X-ray absorptiometry, with appendicular skeletal muscle mass expressed with respect to body area. Weight, BMI, albuminaemia, serum transthyretin and C-reactive protein values were also determined on admission, and known risk factors, such as functional dependence and invasive biomedical material, were also evaluated. After up to 3 weeks of hospitalisation, patients were classified according to whether they had developed an NI. After 3 weeks of hospitalisation, we found that twenty-nine patients had suffered an NI, occurring after a mean of 16·1 d. Patients who were sarcopenic on admission had a significantly higher risk of contracting an NI (relative risk 2·1, 95 % CI 1·1, 3·8). None of the other morphometric or biological parameters differed significantly between the two groups of patients on admission. Patients who experienced an NI were also more likely, on admission, to have a medical device (P=0·02 to P=0·001 depending on the device), to have swallowing problems (P=0·002) or to have restricted autonomy (P<0·01). Sarcopenia on admission to an acute care of the elderly unit, as measured by X-ray absorptiometry, was therefore associated with a doubled risk of NI during the first 3 weeks of hospitalisation.

• 3

  Risk factors for deep vein thrombosis in inpatients aged 65 and older: a case-control multicenter study

  Journal of the American Geriatrics Society · 2004

  📚 107 citations🎯 RCR 2.91Top 17% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  Objectives: To identify independent risk factors of symptomatic deep vein thrombosis (DVT) in geriatric inpatients and to define high‐risk patients likely to benefit from preventive treatment. Design: Hospital‐based case‐control multicenter study with prospective data collection. Settings: Geriatric university hospitals with long‐, intermediate‐, and short‐term care facilities. Participants: All patients aged 65 and older in 19 geriatric departments were submitted to clinical surveillance over a 16‐month period. Measurements: Twenty‐three potential risk factors of phlebitis were screened for. Comparison using logistic regression of 310 consecutive patients with symptomatic DVT versus 310 randomly selected controls was performed. The risk for symptomatic DVT in geriatrics was then scored from the clinical risk factors identified using multivariate analysis. This score is defined by the sum of the odds ratio (OR) of each risk factor present. Results: Six factors were identified as independently related to the development of DVT: restriction of mobility (from OR=1.73, limited mobility without immobilization, to OR=5.64, bedridden during <15 days), aged 75 and older (OR=1.5/10 years), history of DVT or pulmonary embolism (OR=3.38), acute heart failure (OR=2.52), chronic edema of the lower limbs (OR=2.51), and paresis or paralysis of a lower limb (OR=2.06). The defined score of 8 or higher corresponded to an 88.7% probability of having symptomatic DVT. Conclusion: Treatments to prevent symptomatic DVT in hospitalized elderly should be evaluated on patients with these factors.

Publications scientifiques (6) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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